Gene name: ESP1
Reference locus (S288C): YGR098C
Gene biotype: protein_coding
Description: Separin; Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
Top 10 interactors (score): PDS1 (0.999); MCD1 (0.999); SMC3 (0.999); SLK19 (0.998); CDC28 (0.997); IRR1 (0.997); PDS5 (0.997); CDC14 (0.997); SMC1 (0.996); BUB1 (0.996); CDC5 (0.996); CDC20 (0.994); SMC4 (0.993); ECO1 (0.992); SMC5 (0.99); BUB3 (0.99); TOP2 (0.99); CDC55 (0.987); MAD3 (0.987); CIN8 (0.987)
Homologues (species, bitscore): ESPL1 (Homo sapiens, 170.2); Espl1 (Mus musculus, 166.4); espl1 (Danio rerio, 167.2); espl1 (Xenopus tropicalis, 149.1); Sse (Drosophila melanogaster, 67.8); sep-1 (Caenorhabditis elegans, 99.0); RSW4 (Arabidopsis thaliana, 142.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:666748-671640:- | gene-YGR098C_AKU4011 | rna-NM_001181227.3_AKU4011 | cds-NP_011612.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000173.1:102607-107499:- | gene-YGR098C_BG1 | rna-NM_001181227.3_BG1 | cds-NP_011612.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:668938-673830:- | gene-YGR098C_Bruggeman | rna-NM_001181227.3_Bruggeman | cds-NP_011612.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:667127-672019:- | gene-YGR098C_CAT1 | rna-NM_001181227.3_CAT1 | cds-NP_011612.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:667711-672603:- | gene-YGR098C_CBS1585 | rna-NM_001181227.3_CBS1585 | cds-NP_011612.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:669369-674261:- | gene-YGR098C_CBS436 | rna-NM_001181227.3_CBS436 | cds-NP_011612.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:659414-664306:- | gene-YGR098C_CBS6412 | rna-NM_001181227.3_CBS6412 | cds-NP_011612.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:664347-669239:- | gene-YGR098C_CBS6413 | rna-NM_001181227.3_CBS6413 | cds-NP_011612.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:682241-687133:- | gene-YGR098C_CENPK1137D | rna-NM_001181227.3_CENPK1137D | cds-NP_011612.3_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:654337-659229:- | gene-YGR098C_EthanolRed | rna-NM_001181227.3_EthanolRed | cds-NP_011612.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:658146-663038:- | gene-YGR098C_FaliES1 | rna-NM_001181227.3_FaliES1 | cds-NP_011612.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000396.1:13517-18409:+ | gene-YGR098C_JAY291 | rna-NM_001181227.3_JAY291 | cds-NP_011612.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:665927-670819:- | gene-YGR098C_MUCL30387 | rna-NM_001181227.3_MUCL30387 | cds-NP_011612.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:668739-673631:- | gene-YGR098C_MUCL30388 | rna-NM_001181227.3_MUCL30388 | cds-NP_011612.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:663442-668334:- | gene-YGR098C_MUCL39482 | rna-NM_001181227.3_MUCL39482 | cds-NP_011612.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:673751-678643:- | gene-YGR098C_MUCL42920 | rna-NM_001181227.3_MUCL42920 | cds-NP_011612.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:682566-687458:- | gene-YGR098C_NCIM3186 | rna-NM_001181227.3_NCIM3186 | cds-NP_011612.3_NCIM3186 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:658130-663022:- | gene-YGR098C_NCYC1407 | rna-NM_001181227.3_NCYC1407 | cds-NP_011612.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:660817-665709:- | gene-YGR098C_PE2H3 | rna-NM_001181227.3_PE2H3 | cds-NP_011612.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:665936-670828:- | gene-YGR098C_PE2H4 | rna-NM_001181227.3_PE2H4 | cds-NP_011612.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:682566-687458:- | gene-YGR098C_S288C | rna-NM_001181227.3_S288C | cds-NP_011612.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000015.1:109175-114067:- | gene-YGR098C_SA1 | rna-NM_001181227.3_SA1 | cds-NP_011612.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:678515-683407:- | gene-YGR098C_ThermosaccDry | rna-NM_001181227.3_ThermosaccDry | cds-NP_011612.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:775005-779897:- | gene-YGR098C_VR1 | rna-NM_001181227.3_VR1 | cds-NP_011612.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000015.1:132762-137654:- | gene-YGR098C_ZTW1 | rna-NM_001181227.3_ZTW1 | cds-NP_011612.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:668551-673443:- | gene-YGR098C_Sparadoxus | rna-NM_001181227.3_Sparadoxus | cds-NP_011612.3_Sparadoxus | 88.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |