Gene name: ESA1
Reference locus (S288C): YOR244W
Gene biotype: protein_coding
Description: Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation
Top 10 interactors (score): YAF9 (0.999); EPL1 (0.999); EAF6 (0.999); EAF3 (0.999); YNG2 (0.999); TRA1 (0.999); ARP4 (0.999); EAF1 (0.998); SWC4 (0.998); HHF1 (0.997); NTO1 (0.997); GCN5 (0.997); RVB1 (0.996); EAF5 (0.996); ACT1 (0.995); HTZ1 (0.992); RPD3 (0.988); EAF7 (0.984); SWD3 (0.981); HTA1 (0.979)
Homologues (species, bitscore): KAT5 (Homo sapiens, 354.8); Kat5 (Mus musculus, 351.7); zgc:92510 (Danio rerio, 356.3); kat8 (Xenopus tropicalis, 324.3); Tip60 (Drosophila melanogaster, 343.2); mys-1 (Caenorhabditis elegans, 372.5); HAG5 (Arabidopsis thaliana, 337.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:783303-784640:+ | gene-YOR244W_AKU4011 | rna-NM_001183663.3_AKU4011 | cds-NP_014887.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:185343-186680:+ | gene-YOR244W_BG1 | rna-NM_001183663.3_BG1 | cds-NP_014887.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:768770-770107:+ | gene-YOR244W_Bruggeman | rna-NM_001183663.3_Bruggeman | cds-NP_014887.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:769421-770758:+ | gene-YOR244W_CAT1 | rna-NM_001183663.3_CAT1 | cds-NP_014887.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:766292-767629:+ | gene-YOR244W_CBS1585 | rna-NM_001183663.3_CBS1585 | cds-NP_014887.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:764987-766324:+ | gene-YOR244W_CBS436 | rna-NM_001183663.3_CBS436 | cds-NP_014887.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:763411-764748:+ | gene-YOR244W_CBS6412 | rna-NM_001183663.3_CBS6412 | cds-NP_014887.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:772051-773388:+ | gene-YOR244W_CBS6413 | rna-NM_001183663.3_CBS6413 | cds-NP_014887.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:792294-793631:+ | gene-YOR244W_CENPK1137D | rna-NM_001183663.3_CENPK1137D | cds-NP_014887.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:759423-760760:+ | gene-YOR244W_EthanolRed | rna-NM_001183663.3_EthanolRed | cds-NP_014887.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:764822-766159:+ | gene-YOR244W_FaliES1 | rna-NM_001183663.3_FaliES1 | cds-NP_014887.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:60678-62015:- | gene-YOR244W_JAY291 | rna-NM_001183663.3_JAY291 | cds-NP_014887.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:773041-774378:+ | gene-YOR244W_MUCL30387 | rna-NM_001183663.3_MUCL30387 | cds-NP_014887.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:780159-781496:+ | gene-YOR244W_MUCL30388 | rna-NM_001183663.3_MUCL30388 | cds-NP_014887.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:773622-774959:+ | gene-YOR244W_MUCL39482 | rna-NM_001183663.3_MUCL39482 | cds-NP_014887.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:783211-784548:+ | gene-YOR244W_MUCL42920 | rna-NM_001183663.3_MUCL42920 | cds-NP_014887.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:792420-793757:+ | gene-YOR244W_NCIM3186 | rna-NM_001183663.3_NCIM3186 | cds-NP_014887.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:773721-775058:+ | gene-YOR244W_NCYC1407 | rna-NM_001183663.3_NCYC1407 | cds-NP_014887.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:773023-774360:+ | gene-YOR244W_PE2H3 | rna-NM_001183663.3_PE2H3 | cds-NP_014887.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:783400-784737:+ | gene-YOR244W_PE2H4 | rna-NM_001183663.3_PE2H4 | cds-NP_014887.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:792531-793868:+ | gene-YOR244W_S288C | rna-NM_001183663.3_S288C | cds-NP_014887.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:202524-203861:+ | gene-YOR244W_SA1 | rna-NM_001183663.3_SA1 | cds-NP_014887.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:764005-765342:+ | gene-YOR244W_ThermosaccDry | rna-NM_001183663.3_ThermosaccDry | cds-NP_014887.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:827463-828800:+ | gene-YOR244W_VR1 | rna-NM_001183663.3_VR1 | cds-NP_014887.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:496921-498258:+ | gene-YOR244W_ZTW1 | rna-NM_001183663.3_ZTW1 | cds-NP_014887.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:769911-771251:+ | gene-YOR244W_Sparadoxus | rna-NM_001183663.3_Sparadoxus | cds-NP_014887.3_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |