Gene name: ERO1
Reference locus (S288C): YML130C
Gene biotype: protein_coding
Description: Endoplasmic oxidoreductin-1; Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L
Top 10 interactors (score): PDI1 (0.999); EUG1 (0.99); KAR2 (0.99); MPD1 (0.981); EPS1 (0.978); LHS1 (0.952); ERV2 (0.943); MPD2 (0.94); CNE1 (0.924); IRE1 (0.923); MIA40 (0.904); HAC1 (0.899); ERV1 (0.888); SEC61 (0.879); DER1 (0.859); OST1 (0.846); HRD1 (0.846); ROT2 (0.837); SCJ1 (0.817); STT3 (0.813)
Homologues (species, bitscore): ERO1LB (Homo sapiens, 203.8); Ero1lb (Mus musculus, 209.9); ero1lb (Danio rerio, 191.8); ero1l (Xenopus tropicalis, 207.6); Ero1L (Drosophila melanogaster, 198.4); ero-1 (Caenorhabditis elegans, 194.5); ERO2 (Arabidopsis thaliana, 198.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:5204-6895:- | gene-YML130C_AKU4011 | rna-NM_001182493.1_AKU4011 | cds-NP_013576.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:470240-471931:+ | gene-YML130C_BG1 | rna-NM_001182493.1_BG1 | cds-NP_013576.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:11439-13130:- | gene-YML130C_Bruggeman | rna-NM_001182493.1_Bruggeman | cds-NP_013576.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:12479-14170:- | gene-YML130C_CAT1 | rna-NM_001182493.1_CAT1 | cds-NP_013576.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:5204-6895:- | gene-YML130C_CBS1585 | rna-NM_001182493.1_CBS1585 | cds-NP_013576.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:11199-12890:- | gene-YML130C_CBS436 | rna-NM_001182493.1_CBS436 | cds-NP_013576.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:5966-7657:- | gene-YML130C_CBS6412 | rna-NM_001182493.1_CBS6412 | cds-NP_013576.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:4422-6113:- | gene-YML130C_CBS6413 | rna-NM_001182493.1_CBS6413 | cds-NP_013576.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:6002-7693:- | gene-YML130C_CENPK1137D | rna-NM_001182493.1_CENPK1137D | cds-NP_013576.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:5719-7410:- | gene-YML130C_EthanolRed | rna-NM_001182493.1_EthanolRed | cds-NP_013576.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:5985-7676:- | gene-YML130C_FaliES1 | rna-NM_001182493.1_FaliES1 | cds-NP_013576.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000345.1:82561-84252:+ | gene-YML130C_JAY291 | rna-NM_001182493.1_JAY291 | cds-NP_013576.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:9496-11187:- | gene-YML130C_MUCL30387 | rna-NM_001182493.1_MUCL30387 | cds-NP_013576.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:12900-14591:- | gene-YML130C_MUCL30388 | rna-NM_001182493.1_MUCL30388 | cds-NP_013576.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:5258-6949:- | gene-YML130C_MUCL39482 | rna-NM_001182493.1_MUCL39482 | cds-NP_013576.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:8672-10363:- | gene-YML130C_MUCL42920 | rna-NM_001182493.1_MUCL42920 | cds-NP_013576.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:11437-13128:- | gene-YML130C_NCIM3186 | rna-NM_001182493.1_NCIM3186 | cds-NP_013576.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:6013-7704:- | gene-YML130C_NCYC1407 | rna-NM_001182493.1_NCYC1407 | cds-NP_013576.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:11388-13079:- | gene-YML130C_PE2H3 | rna-NM_001182493.1_PE2H3 | cds-NP_013576.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:11326-13017:- | gene-YML130C_PE2H4 | rna-NM_001182493.1_PE2H4 | cds-NP_013576.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:11483-13174:- | gene-YML130C_S288C | rna-NM_001182493.1_S288C | cds-NP_013576.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000054.1:3313-5004:- | gene-YML130C_SA1 | rna-NM_001182493.1_SA1 | cds-NP_013576.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:5294-6985:- | gene-YML130C_ThermosaccDry | rna-NM_001182493.1_ThermosaccDry | cds-NP_013576.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:9691-11382:- | gene-YML130C_VR1 | rna-NM_001182493.1_VR1 | cds-NP_013576.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000026.1:4482-6173:- | gene-YML130C_ZTW1 | rna-NM_001182493.1_ZTW1 | cds-NP_013576.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:16334-18025:- | gene-YML130C_Sparadoxus | rna-NM_001182493.1_Sparadoxus | cds-NP_013576.1_Sparadoxus | 91.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |