Gene name: ERG4
Reference locus (S288C): YGL012W
Gene biotype: protein_coding
Description: C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; Belongs to the ERG4/ERG24 family
Top 10 interactors (score): ERG5 (0.999); ERG6 (0.999); ERG11 (0.998); ERG1 (0.997); ERG25 (0.997); ERG26 (0.996); ERG2 (0.996); ERG27 (0.995); ERG28 (0.994); ERG7 (0.985); ERG3 (0.98); ERG24 (0.97); ERG9 (0.938); ERG10 (0.918); ERG12 (0.891); ERG13 (0.889); ERG20 (0.858); MVD1 (0.856); ERG8 (0.836); STE20 (0.823)
Homologues (species, bitscore): LBR (Homo sapiens, 208.8); Lbr (Mus musculus, 198.4); tm7sf2 (Danio rerio, 194.9); tm7sf2 (Xenopus tropicalis, 185.3); LBR (Drosophila melanogaster, 50.4); dhcr-7 (Caenorhabditis elegans, 80.1); FK (Arabidopsis thaliana, 135.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:474906-476327:+ | gene-YGL012W_AKU4011 | rna-NM_001180877.1_AKU4011 | cds-NP_011503.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:99783-101204:- | gene-YGL012W_BG1 | rna-NM_001180877.1_BG1 | cds-NP_011503.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:475875-477296:+ | gene-YGL012W_Bruggeman | rna-NM_001180877.1_Bruggeman | cds-NP_011503.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:474168-475589:+ | gene-YGL012W_CAT1 | rna-NM_001180877.1_CAT1 | cds-NP_011503.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:476377-477798:+ | gene-YGL012W_CBS1585 | rna-NM_001180877.1_CBS1585 | cds-NP_011503.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:470757-472178:+ | gene-YGL012W_CBS436 | rna-NM_001180877.1_CBS436 | cds-NP_011503.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:468992-470413:+ | gene-YGL012W_CBS6412 | rna-NM_001180877.1_CBS6412 | cds-NP_011503.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:473048-474469:+ | gene-YGL012W_CBS6413 | rna-NM_001180877.1_CBS6413 | cds-NP_011503.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:472676-474097:+ | gene-YGL012W_CENPK1137D | rna-NM_001180877.1_CENPK1137D | cds-NP_011503.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:463273-464694:+ | gene-YGL012W_EthanolRed | rna-NM_001180877.1_EthanolRed | cds-NP_011503.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:466529-467950:+ | gene-YGL012W_FaliES1 | rna-NM_001180877.1_FaliES1 | cds-NP_011503.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000020.1:5164-6585:+ | gene-YGL012W_JAY291 | rna-NM_001180877.1_JAY291 | cds-NP_011503.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:473098-474519:+ | gene-YGL012W_MUCL30387 | rna-NM_001180877.1_MUCL30387 | cds-NP_011503.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:475647-477068:+ | gene-YGL012W_MUCL30388 | rna-NM_001180877.1_MUCL30388 | cds-NP_011503.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:472216-473637:+ | gene-YGL012W_MUCL39482 | rna-NM_001180877.1_MUCL39482 | cds-NP_011503.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:481653-483074:+ | gene-YGL012W_MUCL42920 | rna-NM_001180877.1_MUCL42920 | cds-NP_011503.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:472855-474276:+ | gene-YGL012W_NCIM3186 | rna-NM_001180877.1_NCIM3186 | cds-NP_011503.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:466238-467659:+ | gene-YGL012W_NCYC1407 | rna-NM_001180877.1_NCYC1407 | cds-NP_011503.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:468932-470353:+ | gene-YGL012W_PE2H3 | rna-NM_001180877.1_PE2H3 | cds-NP_011503.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:473982-475403:+ | gene-YGL012W_PE2H4 | rna-NM_001180877.1_PE2H4 | cds-NP_011503.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:472855-474276:+ | gene-YGL012W_S288C | rna-NM_001180877.1_S288C | cds-NP_011503.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000021.1:81308-82729:- | gene-YGL012W_SA1 | rna-NM_001180877.1_SA1 | cds-NP_011503.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:485854-487275:+ | gene-YGL012W_ThermosaccDry | rna-NM_001180877.1_ThermosaccDry | cds-NP_011503.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:575939-577360:+ | gene-YGL012W_VR1 | rna-NM_001180877.1_VR1 | cds-NP_011503.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:464460-465881:+ | gene-YGL012W_ZTW1 | rna-NM_001180877.1_ZTW1 | cds-NP_011503.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:474009-475430:+ | gene-YGL012W_Sparadoxus | rna-NM_001180877.1_Sparadoxus | cds-NP_011503.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |