Gene name: ERG3
Reference locus (S288C): YLR056W
Gene biotype: protein_coding
Description: Delta(7)-sterol 5(6)-desaturase; C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D
Top 10 interactors (score): ERG9 (0.999); ERG7 (0.999); ERG25 (0.999); ERG11 (0.999); ERG6 (0.999); ERG24 (0.999); ERG5 (0.999); ERG2 (0.999); ERG28 (0.999); ERG1 (0.997); ERG26 (0.996); ERG27 (0.995); ERG4 (0.98); SCS7 (0.953); ERG13 (0.94); UPC2 (0.926); OLE1 (0.904); ERG20 (0.883); ERG10 (0.876); IDI1 (0.873)
Homologues (species, bitscore): SC5D (Homo sapiens, 259.6); Sc5d (Mus musculus, 250.8); sc5d (Danio rerio, 252.7); faxdc2 (Xenopus tropicalis, 52.4); CG11162 (Drosophila melanogaster, 55.5); F49E12.9 (Caenorhabditis elegans, 50.1); STE1 (Arabidopsis thaliana, 94.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:236347-237444:+ | gene-YLR056W_AKU4011 | rna-NM_001181943.1_AKU4011 | cds-NP_013157.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:199468-200565:+ | gene-YLR056W_BG1 | rna-NM_001181943.1_BG1 | cds-NP_013157.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:246256-247353:+ | gene-YLR056W_Bruggeman | rna-NM_001181943.1_Bruggeman | cds-NP_013157.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:246561-247658:+ | gene-YLR056W_CAT1 | rna-NM_001181943.1_CAT1 | cds-NP_013157.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:243482-244579:+ | gene-YLR056W_CBS1585 | rna-NM_001181943.1_CBS1585 | cds-NP_013157.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:234095-235192:+ | gene-YLR056W_CBS436 | rna-NM_001181943.1_CBS436 | cds-NP_013157.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:241891-242988:+ | gene-YLR056W_CBS6412 | rna-NM_001181943.1_CBS6412 | cds-NP_013157.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:243745-244842:+ | gene-YLR056W_CBS6413 | rna-NM_001181943.1_CBS6413 | cds-NP_013157.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:233118-234215:+ | gene-YLR056W_CENPK1137D | rna-NM_001181943.1_CENPK1137D | cds-NP_013157.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:235858-236955:+ | gene-YLR056W_EthanolRed | rna-NM_001181943.1_EthanolRed | cds-NP_013157.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:235746-236843:+ | gene-YLR056W_FaliES1 | rna-NM_001181943.1_FaliES1 | cds-NP_013157.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:10666-11763:+ | gene-YLR056W_JAY291 | rna-NM_001181943.1_JAY291 | cds-NP_013157.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:243609-244706:+ | gene-YLR056W_MUCL30387 | rna-NM_001181943.1_MUCL30387 | cds-NP_013157.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:251264-252361:+ | gene-YLR056W_MUCL30388 | rna-NM_001181943.1_MUCL30388 | cds-NP_013157.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:243977-245074:+ | gene-YLR056W_MUCL39482 | rna-NM_001181943.1_MUCL39482 | cds-NP_013157.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:243881-244978:+ | gene-YLR056W_MUCL42920 | rna-NM_001181943.1_MUCL42920 | cds-NP_013157.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:253835-254932:+ | gene-YLR056W_NCIM3186 | rna-NM_001181943.1_NCIM3186 | cds-NP_013157.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:236038-237135:+ | gene-YLR056W_NCYC1407 | rna-NM_001181943.1_NCYC1407 | cds-NP_013157.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:241903-243000:+ | gene-YLR056W_PE2H3 | rna-NM_001181943.1_PE2H3 | cds-NP_013157.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:241644-242741:+ | gene-YLR056W_PE2H4 | rna-NM_001181943.1_PE2H4 | cds-NP_013157.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:253861-254958:+ | gene-YLR056W_S288C | rna-NM_001181943.1_S288C | cds-NP_013157.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000046.1:79714-80811:+ | gene-YLR056W_SA1 | rna-NM_001181943.1_SA1 | cds-NP_013157.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:235931-237028:+ | gene-YLR056W_ThermosaccDry | rna-NM_001181943.1_ThermosaccDry | cds-NP_013157.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:249594-250691:+ | gene-YLR056W_VR1 | rna-NM_001181943.1_VR1 | cds-NP_013157.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:235294-236391:+ | gene-YLR056W_ZTW1 | rna-NM_001181943.1_ZTW1 | cds-NP_013157.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:244155-245252:+ | gene-YLR056W_Sparadoxus | rna-NM_001181943.1_Sparadoxus | cds-NP_013157.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |