Gene name: ERG27
Reference locus (S288C): YLR100W
Gene biotype: protein_coding
Description: 3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily
Top 10 interactors (score): ERG11 (0.999); ERG28 (0.999); ERG6 (0.999); ERG9 (0.999); ERG25 (0.999); ERG26 (0.999); ERG7 (0.999); ERG24 (0.997); ERG3 (0.995); ERG4 (0.995); ERG1 (0.993); ERG5 (0.986); IDI1 (0.962); ERG12 (0.928); ERG13 (0.92); ERG8 (0.917); ERG2 (0.917); IFA38 (0.916); ERG10 (0.895); ERG20 (0.883)
Homologues (species, bitscore): HSD17B7 (Homo sapiens, 80.1); Hsd17b7 (Mus musculus, 86.3); Hsd17b7 (Danio rerio, 82.0); hsd17b7 (Xenopus tropicalis, 89.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:324307-325350:+ | gene-YLR100W_AKU4011 | rna-NM_001181987.1_AKU4011 | cds-NP_013201.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:287490-288533:+ | gene-YLR100W_BG1 | rna-NM_001181987.1_BG1 | cds-NP_013201.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:334157-335200:+ | gene-YLR100W_Bruggeman | rna-NM_001181987.1_Bruggeman | cds-NP_013201.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:334511-335554:+ | gene-YLR100W_CAT1 | rna-NM_001181987.1_CAT1 | cds-NP_013201.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:331449-332492:+ | gene-YLR100W_CBS1585 | rna-NM_001181987.1_CBS1585 | cds-NP_013201.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:322018-323061:+ | gene-YLR100W_CBS436 | rna-NM_001181987.1_CBS436 | cds-NP_013201.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:329868-330911:+ | gene-YLR100W_CBS6412 | rna-NM_001181987.1_CBS6412 | cds-NP_013201.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:331715-332758:+ | gene-YLR100W_CBS6413 | rna-NM_001181987.1_CBS6413 | cds-NP_013201.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:326834-327877:+ | gene-YLR100W_CENPK1137D | rna-NM_001181987.1_CENPK1137D | cds-NP_013201.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:323866-324909:+ | gene-YLR100W_EthanolRed | rna-NM_001181987.1_EthanolRed | cds-NP_013201.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:323685-324728:+ | gene-YLR100W_FaliES1 | rna-NM_001181987.1_FaliES1 | cds-NP_013201.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:98619-99662:+ | gene-YLR100W_JAY291 | rna-NM_001181987.1_JAY291 | cds-NP_013201.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:331536-332579:+ | gene-YLR100W_MUCL30387 | rna-NM_001181987.1_MUCL30387 | cds-NP_013201.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:339201-340244:+ | gene-YLR100W_MUCL30388 | rna-NM_001181987.1_MUCL30388 | cds-NP_013201.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:331957-333000:+ | gene-YLR100W_MUCL39482 | rna-NM_001181987.1_MUCL39482 | cds-NP_013201.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:331861-332904:+ | gene-YLR100W_MUCL42920 | rna-NM_001181987.1_MUCL42920 | cds-NP_013201.1_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:341784-342827:+ | gene-YLR100W_NCIM3186 | rna-NM_001181987.1_NCIM3186 | cds-NP_013201.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:324020-325063:+ | gene-YLR100W_NCYC1407 | rna-NM_001181987.1_NCYC1407 | cds-NP_013201.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:329784-330827:+ | gene-YLR100W_PE2H3 | rna-NM_001181987.1_PE2H3 | cds-NP_013201.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:329525-330568:+ | gene-YLR100W_PE2H4 | rna-NM_001181987.1_PE2H4 | cds-NP_013201.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:341810-342853:+ | gene-YLR100W_S288C | rna-NM_001181987.1_S288C | cds-NP_013201.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000033.1:31244-32287:- | gene-YLR100W_SA1 | rna-NM_001181987.1_SA1 | cds-NP_013201.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:323858-324901:+ | gene-YLR100W_ThermosaccDry | rna-NM_001181987.1_ThermosaccDry | cds-NP_013201.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:338025-339068:+ | gene-YLR100W_VR1 | rna-NM_001181987.1_VR1 | cds-NP_013201.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:323285-324328:+ | gene-YLR100W_ZTW1 | rna-NM_001181987.1_ZTW1 | cds-NP_013201.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:332085-333131:+ | gene-YLR100W_Sparadoxus | rna-NM_001181987.1_Sparadoxus | cds-NP_013201.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |