Gene name: ERG26
Reference locus (S288C): YGL001C
Gene biotype: protein_coding
Description: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456; Belongs to the 3-beta-HSD family
Top 10 interactors (score): ERG28 (0.999); ERG1 (0.999); ERG27 (0.999); ERG9 (0.999); ERG25 (0.999); ERG7 (0.999); ERG11 (0.999); ERG6 (0.999); ERG24 (0.998); ERG2 (0.996); ERG3 (0.996); ERG4 (0.996); IDI1 (0.992); ERG10 (0.975); ERG13 (0.974); ERG20 (0.951); ERG5 (0.937); HEM1 (0.926); ERG12 (0.906); HEM3 (0.901)
Homologues (species, bitscore): NSDHL (Homo sapiens, 221.9); Nsdhl (Mus musculus, 223.8); nsdhl (Danio rerio, 218.0); nsdhl (Xenopus tropicalis, 228.8); CG7724 (Drosophila melanogaster, 73.2); hsd-2 (Caenorhabditis elegans, 102.8); RTNLB24 (Arabidopsis thaliana, 189.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:497504-498553:- | gene-YGL001C_AKU4011 | rna-NM_001180866.1_AKU4011 | cds-NP_011514.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:77557-78606:+ | gene-YGL001C_BG1 | rna-NM_001180866.1_BG1 | cds-NP_011514.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:498473-499522:- | gene-YGL001C_Bruggeman | rna-NM_001180866.1_Bruggeman | cds-NP_011514.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:497017-498066:- | gene-YGL001C_CAT1 | rna-NM_001180866.1_CAT1 | cds-NP_011514.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:498998-500047:- | gene-YGL001C_CBS1585 | rna-NM_001180866.1_CBS1585 | cds-NP_011514.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:493359-494408:- | gene-YGL001C_CBS436 | rna-NM_001180866.1_CBS436 | cds-NP_011514.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:491593-492642:- | gene-YGL001C_CBS6412 | rna-NM_001180866.1_CBS6412 | cds-NP_011514.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:495669-496718:- | gene-YGL001C_CBS6413 | rna-NM_001180866.1_CBS6413 | cds-NP_011514.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:495270-496319:- | gene-YGL001C_CENPK1137D | rna-NM_001180866.1_CENPK1137D | cds-NP_011514.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:485875-486924:- | gene-YGL001C_EthanolRed | rna-NM_001180866.1_EthanolRed | cds-NP_011514.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:489127-490176:- | gene-YGL001C_FaliES1 | rna-NM_001180866.1_FaliES1 | cds-NP_011514.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000020.1:27758-28807:- | gene-YGL001C_JAY291 | rna-NM_001180866.1_JAY291 | cds-NP_011514.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:495695-496744:- | gene-YGL001C_MUCL30387 | rna-NM_001180866.1_MUCL30387 | cds-NP_011514.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:498245-499294:- | gene-YGL001C_MUCL30388 | rna-NM_001180866.1_MUCL30388 | cds-NP_011514.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:494816-495865:- | gene-YGL001C_MUCL39482 | rna-NM_001180866.1_MUCL39482 | cds-NP_011514.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:504248-505297:- | gene-YGL001C_MUCL42920 | rna-NM_001180866.1_MUCL42920 | cds-NP_011514.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:495453-496502:- | gene-YGL001C_NCIM3186 | rna-NM_001180866.1_NCIM3186 | cds-NP_011514.1_NCIM3186 | 94.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:488857-489906:- | gene-YGL001C_NCYC1407 | rna-NM_001180866.1_NCYC1407 | cds-NP_011514.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:491526-492575:- | gene-YGL001C_PE2H3 | rna-NM_001180866.1_PE2H3 | cds-NP_011514.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:496576-497625:- | gene-YGL001C_PE2H4 | rna-NM_001180866.1_PE2H4 | cds-NP_011514.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:495453-496502:- | gene-YGL001C_S288C | rna-NM_001180866.1_S288C | cds-NP_011514.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000021.1:59080-60129:+ | gene-YGL001C_SA1 | rna-NM_001180866.1_SA1 | cds-NP_011514.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:508452-509501:- | gene-YGL001C_ThermosaccDry | rna-NM_001180866.1_ThermosaccDry | cds-NP_011514.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:598488-599537:- | gene-YGL001C_VR1 | rna-NM_001180866.1_VR1 | cds-NP_011514.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:487051-488100:- | gene-YGL001C_ZTW1 | rna-NM_001180866.1_ZTW1 | cds-NP_011514.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:496668-497717:- | gene-YGL001C_Sparadoxus | rna-NM_001180866.1_Sparadoxus | cds-NP_011514.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |