Gene name: ERG25
Reference locus (S288C): YGR060W
Gene biotype: protein_coding
Description: Methylsterol monooxygenase; C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression
Top 10 interactors (score): ERG27 (0.999); ERG1 (0.999); ERG2 (0.999); ERG11 (0.999); ERG5 (0.999); ERG7 (0.999); ERG9 (0.999); ERG3 (0.999); ERG28 (0.999); ERG26 (0.999); ERG6 (0.998); ERG4 (0.997); ERG24 (0.997); ERG13 (0.994); HMG1 (0.979); IDI1 (0.969); MVD1 (0.959); HMG2 (0.953); ERG20 (0.953); HEM2 (0.932)
Homologues (species, bitscore): MSMO1 (Homo sapiens, 190.7); Msmo1 (Mus musculus, 188.0); msmo1 (Danio rerio, 177.6); msmo1 (Xenopus tropicalis, 175.3); CG11162 (Drosophila melanogaster, 89.7); F49E12.9 (Caenorhabditis elegans, 86.3); SMO2-1 (Arabidopsis thaliana, 181.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:594264-595193:+ | gene-YGR060W_AKU4011 | rna-NM_001181189.3_AKU4011 | cds-NP_011574.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000173.1:30659-31588:+ | gene-YGR060W_BG1 | rna-NM_001181189.3_BG1 | cds-NP_011574.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:596544-597473:+ | gene-YGR060W_Bruggeman | rna-NM_001181189.3_Bruggeman | cds-NP_011574.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:594970-595899:+ | gene-YGR060W_CAT1 | rna-NM_001181189.3_CAT1 | cds-NP_011574.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:595578-596507:+ | gene-YGR060W_CBS1585 | rna-NM_001181189.3_CBS1585 | cds-NP_011574.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:596866-597795:+ | gene-YGR060W_CBS436 | rna-NM_001181189.3_CBS436 | cds-NP_011574.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:588373-589302:+ | gene-YGR060W_CBS6412 | rna-NM_001181189.3_CBS6412 | cds-NP_011574.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:592369-593298:+ | gene-YGR060W_CBS6413 | rna-NM_001181189.3_CBS6413 | cds-NP_011574.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:610301-611230:+ | gene-YGR060W_CENPK1137D | rna-NM_001181189.3_CENPK1137D | cds-NP_011574.3_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:582503-583432:+ | gene-YGR060W_EthanolRed | rna-NM_001181189.3_EthanolRed | cds-NP_011574.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:585987-586916:+ | gene-YGR060W_FaliES1 | rna-NM_001181189.3_FaliES1 | cds-NP_011574.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000435.1:36925-37854:+ | gene-YGR060W_JAY291 | rna-NM_001181189.3_JAY291 | cds-NP_011574.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:593177-594106:+ | gene-YGR060W_MUCL30387 | rna-NM_001181189.3_MUCL30387 | cds-NP_011574.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:596574-597503:+ | gene-YGR060W_MUCL30388 | rna-NM_001181189.3_MUCL30388 | cds-NP_011574.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:591395-592324:+ | gene-YGR060W_MUCL39482 | rna-NM_001181189.3_MUCL39482 | cds-NP_011574.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:601202-602131:+ | gene-YGR060W_MUCL42920 | rna-NM_001181189.3_MUCL42920 | cds-NP_011574.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:610564-611493:+ | gene-YGR060W_NCIM3186 | rna-NM_001181189.3_NCIM3186 | cds-NP_011574.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:585593-586522:+ | gene-YGR060W_NCYC1407 | rna-NM_001181189.3_NCYC1407 | cds-NP_011574.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:588830-589759:+ | gene-YGR060W_PE2H3 | rna-NM_001181189.3_PE2H3 | cds-NP_011574.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:593937-594866:+ | gene-YGR060W_PE2H4 | rna-NM_001181189.3_PE2H4 | cds-NP_011574.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:610564-611493:+ | gene-YGR060W_S288C | rna-NM_001181189.3_S288C | cds-NP_011574.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000015.1:37029-37958:+ | gene-YGR060W_SA1 | rna-NM_001181189.3_SA1 | cds-NP_011574.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:605325-606254:+ | gene-YGR060W_ThermosaccDry | rna-NM_001181189.3_ThermosaccDry | cds-NP_011574.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:702251-703180:+ | gene-YGR060W_VR1 | rna-NM_001181189.3_VR1 | cds-NP_011574.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000015.1:60795-61724:+ | gene-YGR060W_ZTW1 | rna-NM_001181189.3_ZTW1 | cds-NP_011574.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:595797-596726:+ | gene-YGR060W_Sparadoxus | rna-NM_001181189.3_Sparadoxus | cds-NP_011574.3_Sparadoxus | 96.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |