Gene name: ERG13
Reference locus (S288C): YML126C
Gene biotype: protein_coding
Description: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
Top 10 interactors (score): ERG10 (0.999); MVD1 (0.999); ERG20 (0.999); HMG1 (0.998); ERG1 (0.997); ERG12 (0.997); HMG2 (0.996); ERG11 (0.996); IDI1 (0.995); ERG25 (0.994); ERG8 (0.994); ERG6 (0.989); ERG9 (0.986); POT1 (0.985); ERG26 (0.974); BTS1 (0.971); ERG7 (0.97); ERG5 (0.967); ERG3 (0.94); ERG2 (0.93)
Homologues (species, bitscore): HMGCS1 (Homo sapiens, 436.0); Hmgcs1 (Mus musculus, 438.7); hmgcs1 (Danio rerio, 439.5); hmgcs1 (Xenopus tropicalis, 439.9); Hmgs (Drosophila melanogaster, 453.0); hmgs-1 (Caenorhabditis elegans, 288.1); HMGS (Arabidopsis thaliana, 414.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:12772-14247:- | gene-YML126C_AKU4011 | rna-NM_001182489.1_AKU4011 | cds-NP_013580.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:462900-464375:+ | gene-YML126C_BG1 | rna-NM_001182489.1_BG1 | cds-NP_013580.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:19013-20488:- | gene-YML126C_Bruggeman | rna-NM_001182489.1_Bruggeman | cds-NP_013580.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:20593-22068:- | gene-YML126C_CAT1 | rna-NM_001182489.1_CAT1 | cds-NP_013580.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:12772-14247:- | gene-YML126C_CBS1585 | rna-NM_001182489.1_CBS1585 | cds-NP_013580.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:18773-20248:- | gene-YML126C_CBS436 | rna-NM_001182489.1_CBS436 | cds-NP_013580.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:13534-15009:- | gene-YML126C_CBS6412 | rna-NM_001182489.1_CBS6412 | cds-NP_013580.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:11998-13473:- | gene-YML126C_CBS6413 | rna-NM_001182489.1_CBS6413 | cds-NP_013580.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:13579-15054:- | gene-YML126C_CENPK1137D | rna-NM_001182489.1_CENPK1137D | cds-NP_013580.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:13285-14760:- | gene-YML126C_EthanolRed | rna-NM_001182489.1_EthanolRed | cds-NP_013580.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:13560-15035:- | gene-YML126C_FaliES1 | rna-NM_001182489.1_FaliES1 | cds-NP_013580.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000345.1:75204-76679:+ | gene-YML126C_JAY291 | rna-NM_001182489.1_JAY291 | cds-NP_013580.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:17058-18533:- | gene-YML126C_MUCL30387 | rna-NM_001182489.1_MUCL30387 | cds-NP_013580.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:20476-21951:- | gene-YML126C_MUCL30388 | rna-NM_001182489.1_MUCL30388 | cds-NP_013580.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:12826-14301:- | gene-YML126C_MUCL39482 | rna-NM_001182489.1_MUCL39482 | cds-NP_013580.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:16246-17721:- | gene-YML126C_MUCL42920 | rna-NM_001182489.1_MUCL42920 | cds-NP_013580.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:19014-20489:- | gene-YML126C_NCIM3186 | rna-NM_001182489.1_NCIM3186 | cds-NP_013580.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:13581-15056:- | gene-YML126C_NCYC1407 | rna-NM_001182489.1_NCYC1407 | cds-NP_013580.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:18961-20436:- | gene-YML126C_PE2H3 | rna-NM_001182489.1_PE2H3 | cds-NP_013580.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:18899-20374:- | gene-YML126C_PE2H4 | rna-NM_001182489.1_PE2H4 | cds-NP_013580.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:19060-20535:- | gene-YML126C_S288C | rna-NM_001182489.1_S288C | cds-NP_013580.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000054.1:10888-12363:- | gene-YML126C_SA1 | rna-NM_001182489.1_SA1 | cds-NP_013580.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:12860-14335:- | gene-YML126C_ThermosaccDry | rna-NM_001182489.1_ThermosaccDry | cds-NP_013580.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:17264-18739:- | gene-YML126C_VR1 | rna-NM_001182489.1_VR1 | cds-NP_013580.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000026.1:12050-13525:- | gene-YML126C_ZTW1 | rna-NM_001182489.1_ZTW1 | cds-NP_013580.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:23959-25432:- | gene-YML126C_Sparadoxus | rna-NM_001182489.1_Sparadoxus | cds-NP_013580.1_Sparadoxus | 94.9 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |