Gene name: ERG12
Reference locus (S288C): YMR208W
Gene biotype: protein_coding
Description: Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation; Belongs to the GHMP kinase family. Mevalonate kinase subfamily
Top 10 interactors (score): ERG8 (0.999); MVD1 (0.999); ERG13 (0.997); HMG1 (0.995); ERG20 (0.994); IDI1 (0.994); HMG2 (0.994); ERG10 (0.993); ERG7 (0.966); ERG9 (0.965); BTS1 (0.933); ERG27 (0.928); ERG25 (0.926); LSB3 (0.918); ERG1 (0.91); ERG26 (0.906); ERG11 (0.892); ERG4 (0.891); ERG6 (0.88); ERG24 (0.858)
Homologues (species, bitscore): MVK (Homo sapiens, 195.3); Mvk (Mus musculus, 193.4); mvk (Danio rerio, 193.4); mvk (Xenopus tropicalis, 195.7); CG33671 (Drosophila melanogaster, 144.8); mvk-1 (Caenorhabditis elegans, 134.4); MK (Arabidopsis thaliana, 158.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:724392-725723:+ | gene-YMR208W_AKU4011 | rna-NM_001182715.1_AKU4011 | cds-NP_013935.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:228884-230215:- | gene-YMR208W_BG1 | rna-NM_001182715.1_BG1 | cds-NP_013935.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:668607-669938:+ | gene-YMR208W_Bruggeman | rna-NM_001182715.1_Bruggeman | cds-NP_013935.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:671862-673193:+ | gene-YMR208W_CAT1 | rna-NM_001182715.1_CAT1 | cds-NP_013935.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:656654-657985:+ | gene-YMR208W_CBS1585 | rna-NM_001182715.1_CBS1585 | cds-NP_013935.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:660906-662237:+ | gene-YMR208W_CBS436 | rna-NM_001182715.1_CBS436 | cds-NP_013935.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:768211-769542:+ | gene-YMR208W_CBS6412 | rna-NM_001182715.1_CBS6412 | cds-NP_013935.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:655802-657133:+ | gene-YMR208W_CBS6413 | rna-NM_001182715.1_CBS6413 | cds-NP_013935.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:679191-680522:+ | gene-YMR208W_CENPK1137D | rna-NM_001182715.1_CENPK1137D | cds-NP_013935.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:716858-718189:+ | gene-YMR208W_EthanolRed | rna-NM_001182715.1_EthanolRed | cds-NP_013935.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:662510-663841:+ | gene-YMR208W_FaliES1 | rna-NM_001182715.1_FaliES1 | cds-NP_013935.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:122196-123527:- | gene-YMR208W_JAY291 | rna-NM_001182715.1_JAY291 | cds-NP_013935.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:662154-663485:+ | gene-YMR208W_MUCL30387 | rna-NM_001182715.1_MUCL30387 | cds-NP_013935.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:668931-670262:+ | gene-YMR208W_MUCL30388 | rna-NM_001182715.1_MUCL30388 | cds-NP_013935.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:657724-659055:+ | gene-YMR208W_MUCL39482 | rna-NM_001182715.1_MUCL39482 | cds-NP_013935.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:665049-666380:+ | gene-YMR208W_MUCL42920 | rna-NM_001182715.1_MUCL42920 | cds-NP_013935.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:684421-685752:+ | gene-YMR208W_NCIM3186 | rna-NM_001182715.1_NCIM3186 | cds-NP_013935.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:657376-658707:+ | gene-YMR208W_NCYC1407 | rna-NM_001182715.1_NCYC1407 | cds-NP_013935.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:667223-668554:+ | gene-YMR208W_PE2H3 | rna-NM_001182715.1_PE2H3 | cds-NP_013935.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:668238-669569:+ | gene-YMR208W_PE2H4 | rna-NM_001182715.1_PE2H4 | cds-NP_013935.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:684467-685798:+ | gene-YMR208W_S288C | rna-NM_001182715.1_S288C | cds-NP_013935.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:122308-123639:- | gene-YMR208W_SA1 | rna-NM_001182715.1_SA1 | cds-NP_013935.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:658681-660012:+ | gene-YMR208W_ThermosaccDry | rna-NM_001182715.1_ThermosaccDry | cds-NP_013935.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:671749-673080:+ | gene-YMR208W_VR1 | rna-NM_001182715.1_VR1 | cds-NP_013935.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:74385-75716:+ | gene-YMR208W_ZTW1 | rna-NM_001182715.1_ZTW1 | cds-NP_013935.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:676454-677785:+ | gene-YMR208W_Sparadoxus | rna-NM_001182715.1_Sparadoxus | cds-NP_013935.1_Sparadoxus | 88.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |