Gene name: ERG11
Reference locus (S288C): YHR007C
Gene biotype: protein_coding
Description: Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation
Top 10 interactors (score): ERG2 (0.999); ERG27 (0.999); ERG1 (0.999); ERG26 (0.999); ERG28 (0.999); ERG3 (0.999); ERG7 (0.999); ERG25 (0.999); ERG9 (0.999); ERG24 (0.999); ERG6 (0.999); ERG4 (0.998); ERG13 (0.996); MVD1 (0.988); NCP1 (0.988); HMG1 (0.987); ERG20 (0.984); IDI1 (0.982); HMG2 (0.975); DAP1 (0.971)
Homologues (species, bitscore): CYP51A1 (Homo sapiens, 323.6); Cyp51 (Mus musculus, 323.6); cyp51 (Danio rerio, 315.1); cyp51a1 (Xenopus tropicalis, 315.5); Cyp6a13 (Drosophila melanogaster, 111.7); cyp-25A2 (Caenorhabditis elegans, 93.6); CYP51G1 (Arabidopsis thaliana, 242.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:108378-109970:- | gene-YHR007C_AKU4011 | rna-NM_001179137.1_AKU4011 | cds-NP_011871.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:28092-29684:- | gene-YHR007C_BG1 | rna-NM_001179137.1_BG1 | cds-NP_011871.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:115214-116806:- | gene-YHR007C_Bruggeman | rna-NM_001179137.1_Bruggeman | cds-NP_011871.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:109447-111039:- | gene-YHR007C_CAT1 | rna-NM_001179137.1_CAT1 | cds-NP_011871.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:108964-110556:- | gene-YHR007C_CBS1585 | rna-NM_001179137.1_CBS1585 | cds-NP_011871.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:101783-103375:- | gene-YHR007C_CBS436 | rna-NM_001179137.1_CBS436 | cds-NP_011871.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:108561-110153:- | gene-YHR007C_CBS6412 | rna-NM_001179137.1_CBS6412 | cds-NP_011871.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:108294-109886:- | gene-YHR007C_CBS6413 | rna-NM_001179137.1_CBS6413 | cds-NP_011871.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:112899-114491:- | gene-YHR007C_CENPK1137D | rna-NM_001179137.1_CENPK1137D | cds-NP_011871.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:108177-109769:- | gene-YHR007C_EthanolRed | rna-NM_001179137.1_EthanolRed | cds-NP_011871.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:109149-110741:- | gene-YHR007C_FaliES1 | rna-NM_001179137.1_FaliES1 | cds-NP_011871.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000064.1:11468-13060:+ | gene-YHR007C_JAY291 | rna-NM_001179137.1_JAY291 | cds-NP_011871.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:112739-114331:- | gene-YHR007C_MUCL30387 | rna-NM_001179137.1_MUCL30387 | cds-NP_011871.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:114638-116230:- | gene-YHR007C_MUCL30388 | rna-NM_001179137.1_MUCL30388 | cds-NP_011871.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:107990-109582:- | gene-YHR007C_MUCL39482 | rna-NM_001179137.1_MUCL39482 | cds-NP_011871.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:112799-114391:- | gene-YHR007C_MUCL42920 | rna-NM_001179137.1_MUCL42920 | cds-NP_011871.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:119973-121565:- | gene-YHR007C_NCIM3186 | rna-NM_001179137.1_NCIM3186 | cds-NP_011871.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:107406-108998:- | gene-YHR007C_NCYC1407 | rna-NM_001179137.1_NCYC1407 | cds-NP_011871.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:109611-111203:- | gene-YHR007C_PE2H3 | rna-NM_001179137.1_PE2H3 | cds-NP_011871.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:117052-118644:- | gene-YHR007C_PE2H4 | rna-NM_001179137.1_PE2H4 | cds-NP_011871.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:120091-121683:- | gene-YHR007C_S288C | rna-NM_001179137.1_S288C | cds-NP_011871.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000075.1:25187-26779:+ | gene-YHR007C_SA1 | rna-NM_001179137.1_SA1 | cds-NP_011871.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:110244-111836:- | gene-YHR007C_ThermosaccDry | rna-NM_001179137.1_ThermosaccDry | cds-NP_011871.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:115767-117359:- | gene-YHR007C_VR1 | rna-NM_001179137.1_VR1 | cds-NP_011871.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:101489-103081:- | gene-YHR007C_ZTW1 | rna-NM_001179137.1_ZTW1 | cds-NP_011871.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:107919-109511:- | gene-YHR007C_Sparadoxus | rna-NM_001179137.1_Sparadoxus | cds-NP_011871.1_Sparadoxus | 94.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |