Gene name: ERG10
Reference locus (S288C): YPL028W
Gene biotype: protein_coding
Description: Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression
Top 10 interactors (score): ERG13 (0.999); MVD1 (0.994); ERG12 (0.993); ERG20 (0.992); IDI1 (0.99); ACS2 (0.985); POX1 (0.985); ERG8 (0.98); ERG9 (0.978); ERG26 (0.975); LAT1 (0.969); ERG5 (0.959); MLS1 (0.958); CIT2 (0.958); ERG6 (0.953); ACH1 (0.951); ACC1 (0.947); ACS1 (0.946); ERG11 (0.944); ERG1 (0.942)
Homologues (species, bitscore): ACAT1 (Homo sapiens, 360.1); Acat1 (Mus musculus, 379.0); acat1 (Danio rerio, 361.7); acat1 (Xenopus tropicalis, 367.1); CG10932 (Drosophila melanogaster, 380.9); kat-1 (Caenorhabditis elegans, 361.7); ACAT2 (Arabidopsis thaliana, 424.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:469588-470784:+ | gene-YPL028W_AKU4011 | rna-NM_001183842.1_AKU4011 | cds-NP_015297.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:426596-427792:- | gene-YPL028W_BG1 | rna-NM_001183842.1_BG1 | cds-NP_015297.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:546548-547744:+ | gene-YPL028W_Bruggeman | rna-NM_001183842.1_Bruggeman | cds-NP_015297.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:586229-587425:+ | gene-YPL028W_CAT1 | rna-NM_001183842.1_CAT1 | cds-NP_015297.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:473658-474854:+ | gene-YPL028W_CBS1585 | rna-NM_001183842.1_CBS1585 | cds-NP_015297.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:487796-488992:+ | gene-YPL028W_CBS436 | rna-NM_001183842.1_CBS436 | cds-NP_015297.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:477850-479046:+ | gene-YPL028W_CBS6412 | rna-NM_001183842.1_CBS6412 | cds-NP_015297.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:470210-471406:+ | gene-YPL028W_CBS6413 | rna-NM_001183842.1_CBS6413 | cds-NP_015297.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:498064-499260:+ | gene-YPL028W_CENPK1137D | rna-NM_001183842.1_CENPK1137D | cds-NP_015297.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:467948-469144:+ | gene-YPL028W_EthanolRed | rna-NM_001183842.1_EthanolRed | cds-NP_015297.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:475778-476974:+ | gene-YPL028W_FaliES1 | rna-NM_001183842.1_FaliES1 | cds-NP_015297.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000283.1:84386-85582:+ | gene-YPL028W_JAY291 | rna-NM_001183842.1_JAY291 | cds-NP_015297.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:487497-488693:+ | gene-YPL028W_MUCL30387 | rna-NM_001183842.1_MUCL30387 | cds-NP_015297.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:486605-487801:+ | gene-YPL028W_MUCL30388 | rna-NM_001183842.1_MUCL30388 | cds-NP_015297.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:466974-468170:+ | gene-YPL028W_MUCL39482 | rna-NM_001183842.1_MUCL39482 | cds-NP_015297.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:525600-526796:+ | gene-YPL028W_MUCL42920 | rna-NM_001183842.1_MUCL42920 | cds-NP_015297.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:498079-499275:+ | gene-YPL028W_NCIM3186 | rna-NM_001183842.1_NCIM3186 | cds-NP_015297.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:474252-475448:+ | gene-YPL028W_NCYC1407 | rna-NM_001183842.1_NCYC1407 | cds-NP_015297.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:480898-482094:+ | gene-YPL028W_PE2H3 | rna-NM_001183842.1_PE2H3 | cds-NP_015297.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:480513-481709:+ | gene-YPL028W_PE2H4 | rna-NM_001183842.1_PE2H4 | cds-NP_015297.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:498096-499292:+ | gene-YPL028W_S288C | rna-NM_001183842.1_S288C | cds-NP_015297.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000029.1:40954-42150:+ | gene-YPL028W_SA1 | rna-NM_001183842.1_SA1 | cds-NP_015297.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:475577-476773:+ | gene-YPL028W_ThermosaccDry | rna-NM_001183842.1_ThermosaccDry | cds-NP_015297.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:490476-491672:+ | gene-YPL028W_VR1 | rna-NM_001183842.1_VR1 | cds-NP_015297.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:474869-476065:+ | gene-YPL028W_ZTW1 | rna-NM_001183842.1_ZTW1 | cds-NP_015297.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:474848-476044:+ | gene-YPL028W_Sparadoxus | rna-NM_001183842.1_Sparadoxus | cds-NP_015297.1_Sparadoxus | 92.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |