Gene name: ERG1
Reference locus (S288C): YGR175C
Gene biotype: protein_coding
Description: Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation
Top 10 interactors (score): ERG5 (0.999); ERG11 (0.999); ERG9 (0.999); ERG7 (0.999); ERG25 (0.999); ERG26 (0.999); ERG2 (0.999); ERG24 (0.998); ERG13 (0.997); ERG4 (0.997); ERG3 (0.997); ERG27 (0.993); IDI1 (0.99); HMG1 (0.988); ERG20 (0.985); HMG2 (0.982); ERG6 (0.978); HEM13 (0.952); ERG28 (0.951); ERG10 (0.942)
Homologues (species, bitscore): SQLE (Homo sapiens, 302.4); Sqle (Mus musculus, 307.8); sqlea (Danio rerio, 310.8); sqle (Xenopus tropicalis, 317.0); SQE3 (Arabidopsis thaliana, 266.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:814690-816180:- | gene-YGR175C_AKU4011 | rna-NM_001181304.1_AKU4011 | cds-NP_011691.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:92811-94301:- | gene-YGR175C_BG1 | rna-NM_001181304.1_BG1 | cds-NP_011691.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:820619-822109:- | gene-YGR175C_Bruggeman | rna-NM_001181304.1_Bruggeman | cds-NP_011691.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:816716-818206:- | gene-YGR175C_CAT1 | rna-NM_001181304.1_CAT1 | cds-NP_011691.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:815405-816895:- | gene-YGR175C_CBS1585 | rna-NM_001181304.1_CBS1585 | cds-NP_011691.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:819294-820784:- | gene-YGR175C_CBS436 | rna-NM_001181304.1_CBS436 | cds-NP_011691.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:806775-808265:- | gene-YGR175C_CBS6412 | rna-NM_001181304.1_CBS6412 | cds-NP_011691.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:812270-813760:- | gene-YGR175C_CBS6413 | rna-NM_001181304.1_CBS6413 | cds-NP_011691.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:846662-848152:- | gene-YGR175C_CENPK1137D | rna-NM_001181304.1_CENPK1137D | cds-NP_011691.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:801280-802770:- | gene-YGR175C_EthanolRed | rna-NM_001181304.1_EthanolRed | cds-NP_011691.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:805671-807161:- | gene-YGR175C_FaliES1 | rna-NM_001181304.1_FaliES1 | cds-NP_011691.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000226.1:8984-10474:+ | gene-YGR175C_JAY291 | rna-NM_001181304.1_JAY291 | cds-NP_011691.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:818109-819599:- | gene-YGR175C_MUCL30387 | rna-NM_001181304.1_MUCL30387 | cds-NP_011691.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:817808-819298:- | gene-YGR175C_MUCL30388 | rna-NM_001181304.1_MUCL30388 | cds-NP_011691.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:810980-812470:- | gene-YGR175C_MUCL39482 | rna-NM_001181304.1_MUCL39482 | cds-NP_011691.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:827596-829086:- | gene-YGR175C_MUCL42920 | rna-NM_001181304.1_MUCL42920 | cds-NP_011691.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:846933-848423:- | gene-YGR175C_NCIM3186 | rna-NM_001181304.1_NCIM3186 | cds-NP_011691.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:806089-807579:- | gene-YGR175C_NCYC1407 | rna-NM_001181304.1_NCYC1407 | cds-NP_011691.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:825280-826770:- | gene-YGR175C_PE2H3 | rna-NM_001181304.1_PE2H3 | cds-NP_011691.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:830390-831880:- | gene-YGR175C_PE2H4 | rna-NM_001181304.1_PE2H4 | cds-NP_011691.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:846933-848423:- | gene-YGR175C_S288C | rna-NM_001181304.1_S288C | cds-NP_011691.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:70590-72080:- | gene-YGR175C_SA1 | rna-NM_001181304.1_SA1 | cds-NP_011691.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:826182-827672:- | gene-YGR175C_ThermosaccDry | rna-NM_001181304.1_ThermosaccDry | cds-NP_011691.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:930430-931920:- | gene-YGR175C_VR1 | rna-NM_001181304.1_VR1 | cds-NP_011691.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:127621-129111:- | gene-YGR175C_ZTW1 | rna-NM_001181304.1_ZTW1 | cds-NP_011691.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:817426-818916:- | gene-YGR175C_Sparadoxus | rna-NM_001181304.1_Sparadoxus | cds-NP_011691.1_Sparadoxus | 94.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |