Gene name: EMP65
Reference locus (S288C): YER140W
Gene biotype: protein_coding
Description: Endoplasmic reticulum membrane protein 65; Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the TAPT1 family
Top 10 interactors (score): SLP1 (0.845); PER33 (0.755); LCL2 (0.745); GLG2 (0.709); AIM22 (0.707); MRPL1 (0.69); OAC1 (0.69); NOP14 (0.649); AFG2 (0.63); SOP4 (0.617); MDM1 (0.615); ERD2 (0.612); URA6 (0.61); GPN2 (0.609); RTT107 (0.603); DIE2 (0.578); EMC5 (0.575); GSF2 (0.574); YJR039W (0.574); GPI10 (0.569)
Homologues (species, bitscore): TAPT1 (Homo sapiens, 167.9); Tapt1 (Mus musculus, 167.9); tapt1 (Danio rerio, 169.5); tapt1 (Xenopus tropicalis, 167.2); CG7218 (Drosophila melanogaster, 174.1); F26F2.7 (Caenorhabditis elegans, 189.9); POD1 (Arabidopsis thaliana, 132.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:439052-440722:+ | gene-YER140W_AKU4011 | rna-NM_001179030.3_AKU4011 | cds-NP_011067.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:103887-105557:- | gene-YER140W_BG1 | rna-NM_001179030.3_BG1 | cds-NP_011067.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:450337-452007:+ | gene-YER140W_Bruggeman | rna-NM_001179030.3_Bruggeman | cds-NP_011067.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:438177-439847:+ | gene-YER140W_CAT1 | rna-NM_001179030.3_CAT1 | cds-NP_011067.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:438852-440522:+ | gene-YER140W_CBS1585 | rna-NM_001179030.3_CBS1585 | cds-NP_011067.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:442677-444347:+ | gene-YER140W_CBS436 | rna-NM_001179030.3_CBS436 | cds-NP_011067.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:437373-439043:+ | gene-YER140W_CBS6412 | rna-NM_001179030.3_CBS6412 | cds-NP_011067.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:444917-446587:+ | gene-YER140W_CBS6413 | rna-NM_001179030.3_CBS6413 | cds-NP_011067.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:449338-451008:+ | gene-YER140W_CENPK1137D | rna-NM_001179030.3_CENPK1137D | cds-NP_011067.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:445333-447003:+ | gene-YER140W_EthanolRed | rna-NM_001179030.3_EthanolRed | cds-NP_011067.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:445919-447589:+ | gene-YER140W_FaliES1 | rna-NM_001179030.3_FaliES1 | cds-NP_011067.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000111.1:38891-40561:- | gene-YER140W_JAY291 | rna-NM_001179030.3_JAY291 | cds-NP_011067.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:439081-440751:+ | gene-YER140W_MUCL30387 | rna-NM_001179030.3_MUCL30387 | cds-NP_011067.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:441972-443642:+ | gene-YER140W_MUCL30388 | rna-NM_001179030.3_MUCL30388 | cds-NP_011067.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:434823-436493:+ | gene-YER140W_MUCL39482 | rna-NM_001179030.3_MUCL39482 | cds-NP_011067.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:446898-448568:+ | gene-YER140W_MUCL42920 | rna-NM_001179030.3_MUCL42920 | cds-NP_011067.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:451564-453234:+ | gene-YER140W_NCIM3186 | rna-NM_001179030.3_NCIM3186 | cds-NP_011067.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:444281-445951:+ | gene-YER140W_NCYC1407 | rna-NM_001179030.3_NCYC1407 | cds-NP_011067.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:459975-461645:+ | gene-YER140W_PE2H3 | rna-NM_001179030.3_PE2H3 | cds-NP_011067.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:449916-451586:+ | gene-YER140W_PE2H4 | rna-NM_001179030.3_PE2H4 | cds-NP_011067.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:451565-453235:+ | gene-YER140W_S288C | rna-NM_001179030.3_S288C | cds-NP_011067.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:9446-11116:+ | gene-YER140W_SA1 | rna-NM_001179030.3_SA1 | cds-NP_011067.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:446717-448387:+ | gene-YER140W_ThermosaccDry | rna-NM_001179030.3_ThermosaccDry | cds-NP_011067.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:439839-441509:+ | gene-YER140W_VR1 | rna-NM_001179030.3_VR1 | cds-NP_011067.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000010.1:1681-3351:+ | gene-YER140W_ZTW1 | rna-NM_001179030.3_ZTW1 | cds-NP_011067.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:447571-449241:+ | gene-YER140W_Sparadoxus | rna-NM_001179030.3_Sparadoxus | cds-NP_011067.3_Sparadoxus | 89.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |