Gene name: EMC4
Reference locus (S288C): YGL231C
Gene biotype: protein_coding
Description: Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4
Top 10 interactors (score): EMC2 (0.999); EMC1 (0.999); EMC3 (0.999); EMC6 (0.999); EMC5 (0.998); EMC10 (0.992); SOP4 (0.967); VPS28 (0.921); YGL230C (0.916); GIM5 (0.887); OPI3 (0.836); GCD7 (0.808); GCD1 (0.783); YET3 (0.773); TIM22 (0.764); ERP5 (0.75); ERG9 (0.742); SAP4 (0.696); SSH1 (0.682); YET1 (0.629)
Homologues (species, bitscore): EMC4 (Homo sapiens, 72.8); Emc4 (Mus musculus, 72.8); emc4 (Xenopus tropicalis, 77.8); CG11137 (Drosophila melanogaster, 86.7); perm-3 (Caenorhabditis elegans, 91.7); AT5G10780 (Arabidopsis thaliana, 67.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:64583-65155:- | gene-YGL231C_AKU4011 | rna-NM_001181097.1_AKU4011 | cds-NP_011283.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000175.1:56616-57188:- | gene-YGL231C_BG1 | rna-NM_001181097.1_BG1 | cds-NP_011283.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:64937-65509:- | gene-YGL231C_Bruggeman | rna-NM_001181097.1_Bruggeman | cds-NP_011283.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:63004-63576:- | gene-YGL231C_CAT1 | rna-NM_001181097.1_CAT1 | cds-NP_011283.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:68870-69442:- | gene-YGL231C_CBS1585 | rna-NM_001181097.1_CBS1585 | cds-NP_011283.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:63589-64161:- | gene-YGL231C_CBS436 | rna-NM_001181097.1_CBS436 | cds-NP_011283.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:56440-57012:- | gene-YGL231C_CBS6412 | rna-NM_001181097.1_CBS6412 | cds-NP_011283.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:62730-63302:- | gene-YGL231C_CBS6413 | rna-NM_001181097.1_CBS6413 | cds-NP_011283.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:62727-63299:- | gene-YGL231C_CENPK1137D | rna-NM_001181097.1_CENPK1137D | cds-NP_011283.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:55670-56242:- | gene-YGL231C_EthanolRed | rna-NM_001181097.1_EthanolRed | cds-NP_011283.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:56255-56827:- | gene-YGL231C_FaliES1 | rna-NM_001181097.1_FaliES1 | cds-NP_011283.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000079.1:10297-10869:+ | gene-YGL231C_JAY291 | rna-NM_001181097.1_JAY291 | cds-NP_011283.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:64864-65436:- | gene-YGL231C_MUCL30387 | rna-NM_001181097.1_MUCL30387 | cds-NP_011283.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:67028-67600:- | gene-YGL231C_MUCL30388 | rna-NM_001181097.1_MUCL30388 | cds-NP_011283.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:65467-66039:- | gene-YGL231C_MUCL39482 | rna-NM_001181097.1_MUCL39482 | cds-NP_011283.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:68348-68920:- | gene-YGL231C_MUCL42920 | rna-NM_001181097.1_MUCL42920 | cds-NP_011283.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:63048-63620:- | gene-YGL231C_NCIM3186 | rna-NM_001181097.1_NCIM3186 | cds-NP_011283.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:57228-57800:- | gene-YGL231C_NCYC1407 | rna-NM_001181097.1_NCYC1407 | cds-NP_011283.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:59085-59657:- | gene-YGL231C_PE2H3 | rna-NM_001181097.1_PE2H3 | cds-NP_011283.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:58633-59205:- | gene-YGL231C_PE2H4 | rna-NM_001181097.1_PE2H4 | cds-NP_011283.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:63048-63620:- | gene-YGL231C_S288C | rna-NM_001181097.1_S288C | cds-NP_011283.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:311709-312281:+ | gene-YGL231C_SA1 | rna-NM_001181097.1_SA1 | cds-NP_011283.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:56561-57133:- | gene-YGL231C_ThermosaccDry | rna-NM_001181097.1_ThermosaccDry | cds-NP_011283.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:63519-64091:- | gene-YGL231C_VR1 | rna-NM_001181097.1_VR1 | cds-NP_011283.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:55605-56177:- | gene-YGL231C_ZTW1 | rna-NM_001181097.1_ZTW1 | cds-NP_011283.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:64250-64822:- | gene-YGL231C_Sparadoxus | rna-NM_001181097.1_Sparadoxus | cds-NP_011283.1_Sparadoxus | 88.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |