Gene name: EFM3
Reference locus (S288C): YJR129C
Gene biotype: protein_coding
Description: Protein-lysine N-methyltransferase EFM3; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A; Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family
Top 10 interactors (score): EFM4 (0.976); EFM2 (0.971); HPM1 (0.956); EFM5 (0.938); BMT2 (0.923); YNL092W (0.919); TAE1 (0.915); MTQ1 (0.895); EFT2 (0.885); RKM2 (0.877); TRM12 (0.846); EFM1 (0.821); RKM1 (0.815); RKM5 (0.815); NNT1 (0.806); EFT1 (0.794); RMT2 (0.793); BMT6 (0.771); CMC4 (0.746); RTS2 (0.733)
Homologues (species, bitscore): FAM86A (Homo sapiens, 62.0); Fam86 (Mus musculus, 50.8); fam86a (Danio rerio, 55.8); mettl21b (Xenopus tropicalis, 51.2); CG7889 (Drosophila melanogaster, 65.5); R08D7.4 (Caenorhabditis elegans, 52.4); AT5G27400 (Arabidopsis thaliana, 57.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:635498-636517:- | gene-YJR129C_AKU4011 | rna-NM_001181787.2_AKU4011 | cds-NP_012663.2_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:37084-38103:+ | gene-YJR129C_BG1 | rna-NM_001181787.2_BG1 | cds-NP_012663.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:651217-652236:- | gene-YJR129C_Bruggeman | rna-NM_001181787.2_Bruggeman | cds-NP_012663.2_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:655870-656889:- | gene-YJR129C_CAT1 | rna-NM_001181787.2_CAT1 | cds-NP_012663.2_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:647542-648561:- | gene-YJR129C_CBS1585 | rna-NM_001181787.2_CBS1585 | cds-NP_012663.2_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:666413-667432:- | gene-YJR129C_CBS436 | rna-NM_001181787.2_CBS436 | cds-NP_012663.2_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:634319-635338:- | gene-YJR129C_CBS6412 | rna-NM_001181787.2_CBS6412 | cds-NP_012663.2_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:636974-637993:- | gene-YJR129C_CBS6413 | rna-NM_001181787.2_CBS6413 | cds-NP_012663.2_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:646360-647379:- | gene-YJR129C_CENPK1137D | rna-NM_001181787.2_CENPK1137D | cds-NP_012663.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:639916-640935:- | gene-YJR129C_EthanolRed | rna-NM_001181787.2_EthanolRed | cds-NP_012663.2_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:651379-652398:- | gene-YJR129C_FaliES1 | rna-NM_001181787.2_FaliES1 | cds-NP_012663.2_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:36756-37775:+ | gene-YJR129C_JAY291 | rna-NM_001181787.2_JAY291 | cds-NP_012663.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:650012-651031:- | gene-YJR129C_MUCL30387 | rna-NM_001181787.2_MUCL30387 | cds-NP_012663.2_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:647735-648754:- | gene-YJR129C_MUCL30388 | rna-NM_001181787.2_MUCL30388 | cds-NP_012663.2_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:641025-642044:- | gene-YJR129C_MUCL39482 | rna-NM_001181787.2_MUCL39482 | cds-NP_012663.2_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:645762-646781:- | gene-YJR129C_MUCL42920 | rna-NM_001181787.2_MUCL42920 | cds-NP_012663.2_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:663979-664998:- | gene-YJR129C_NCIM3186 | rna-NM_001181787.2_NCIM3186 | cds-NP_012663.2_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:638576-639595:- | gene-YJR129C_NCYC1407 | rna-NM_001181787.2_NCYC1407 | cds-NP_012663.2_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:656765-657784:- | gene-YJR129C_PE2H3 | rna-NM_001181787.2_PE2H3 | cds-NP_012663.2_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:650454-651473:- | gene-YJR129C_PE2H4 | rna-NM_001181787.2_PE2H4 | cds-NP_012663.2_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:664000-665019:- | gene-YJR129C_S288C | rna-NM_001181787.2_S288C | cds-NP_012663.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:37109-38128:+ | gene-YJR129C_SA1 | rna-NM_001181787.2_SA1 | cds-NP_012663.2_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:645310-646329:- | gene-YJR129C_ThermosaccDry | rna-NM_001181787.2_ThermosaccDry | cds-NP_012663.2_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:647687-648706:- | gene-YJR129C_VR1 | rna-NM_001181787.2_VR1 | cds-NP_012663.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:624662-625681:- | gene-YJR129C_ZTW1 | rna-NM_001181787.2_ZTW1 | cds-NP_012663.2_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:658873-659892:- | gene-YJR129C_Sparadoxus | rna-NM_001181787.2_Sparadoxus | cds-NP_012663.2_Sparadoxus | 86.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |