Gene name: EFM2
Reference locus (S288C): YBR271W
Gene biotype: protein_coding
Description: Protein-lysine N-methyltransferase EFM2; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis; Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family
Top 10 interactors (score): EFM3 (0.971); EFM4 (0.967); BMT2 (0.96); HPM1 (0.949); RCM1 (0.942); YGR283C (0.935); CDC48 (0.919); BMT5 (0.91); YMR310C (0.908); EFM1 (0.903); RKM2 (0.875); TAE1 (0.873); YNL092W (0.873); RKM1 (0.864); MTQ1 (0.861); SFM1 (0.851); RKM5 (0.842); RRP8 (0.837); NNT1 (0.836); YBL028C (0.836)
Homologues (species, bitscore): VCPKMT (Homo sapiens, 60.5); Mettl21b (Mus musculus, 60.5); vcpkmt (Danio rerio, 50.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:729138-730397:+ | gene-YBR271W_AKU4011 | rna-NM_001178619.3_AKU4011 | cds-NP_009830.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:100158-101417:+ | gene-YBR271W_BG1 | rna-NM_001178619.3_BG1 | cds-NP_009830.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:730297-731556:+ | gene-YBR271W_Bruggeman | rna-NM_001178619.3_Bruggeman | cds-NP_009830.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:734024-735283:+ | gene-YBR271W_CAT1 | rna-NM_001178619.3_CAT1 | cds-NP_009830.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:720704-721963:+ | gene-YBR271W_CBS1585 | rna-NM_001178619.3_CBS1585 | cds-NP_009830.3_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:727145-728404:+ | gene-YBR271W_CBS436 | rna-NM_001178619.3_CBS436 | cds-NP_009830.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:815319-816578:+ | gene-YBR271W_CBS6412 | rna-NM_001178619.3_CBS6412 | cds-NP_009830.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:726752-728011:+ | gene-YBR271W_CBS6413 | rna-NM_001178619.3_CBS6413 | cds-NP_009830.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:738759-740018:+ | gene-YBR271W_CENPK1137D | rna-NM_001178619.3_CENPK1137D | cds-NP_009830.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:852173-853432:+ | gene-YBR271W_EthanolRed | rna-NM_001178619.3_EthanolRed | cds-NP_009830.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:745520-746779:+ | gene-YBR271W_FaliES1 | rna-NM_001178619.3_FaliES1 | cds-NP_009830.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000067.1:57282-58541:- | gene-YBR271W_JAY291 | rna-NM_001178619.3_JAY291 | cds-NP_009830.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:732340-733599:+ | gene-YBR271W_MUCL30387 | rna-NM_001178619.3_MUCL30387 | cds-NP_009830.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:749421-750680:+ | gene-YBR271W_MUCL30388 | rna-NM_001178619.3_MUCL30388 | cds-NP_009830.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:719011-720270:+ | gene-YBR271W_MUCL39482 | rna-NM_001178619.3_MUCL39482 | cds-NP_009830.3_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:728877-730136:+ | gene-YBR271W_MUCL42920 | rna-NM_001178619.3_MUCL42920 | cds-NP_009830.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:744649-745908:+ | gene-YBR271W_NCIM3186 | rna-NM_001178619.3_NCIM3186 | cds-NP_009830.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:720900-722159:+ | gene-YBR271W_NCYC1407 | rna-NM_001178619.3_NCYC1407 | cds-NP_009830.3_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:744026-745285:+ | gene-YBR271W_PE2H3 | rna-NM_001178619.3_PE2H3 | cds-NP_009830.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:741702-742961:+ | gene-YBR271W_PE2H4 | rna-NM_001178619.3_PE2H4 | cds-NP_009830.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:744852-746111:+ | gene-YBR271W_S288C | rna-NM_001178619.3_S288C | cds-NP_009830.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:99980-101239:+ | gene-YBR271W_SA1 | rna-NM_001178619.3_SA1 | cds-NP_009830.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:744512-745771:+ | gene-YBR271W_ThermosaccDry | rna-NM_001178619.3_ThermosaccDry | cds-NP_009830.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:724724-725983:+ | gene-YBR271W_VR1 | rna-NM_001178619.3_VR1 | cds-NP_009830.3_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:717357-718616:+ | gene-YBR271W_ZTW1 | rna-NM_001178619.3_ZTW1 | cds-NP_009830.3_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:761277-762530:+ | gene-YBR271W_Sparadoxus | rna-NM_001178619.3_Sparadoxus | cds-NP_009830.3_Sparadoxus | 86.7 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |