Gene name: EDE1
Reference locus (S288C): YBL047C
Gene biotype: protein_coding
Description: EH domain-containing and endocytosis protein 1; Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15; Belongs to the VDP/USO1/EDE1 family
Top 10 interactors (score): ENT1 (0.999); ENT2 (0.999); APL3 (0.999); VPS27 (0.997); APM4 (0.996); YAP1801 (0.995); SLA2 (0.994); RVS161 (0.994); YAP1802 (0.994); CHC1 (0.992); SYP1 (0.984); PRK1 (0.982); VPS1 (0.976); CLC1 (0.975); UBI4 (0.975); BZZ1 (0.975); ABP1 (0.973); INP52 (0.97); APS2 (0.964); DNM1 (0.961)
Homologues (species, bitscore): EPS15 (Homo sapiens, 144.1); Eps15l1 (Mus musculus, 139.8); eps15 (Danio rerio, 155.2); eps15 (Xenopus tropicalis, 146.4); Eps-15 (Drosophila melanogaster, 123.2); itsn-1 (Caenorhabditis elegans, 94.0); AT1G21630 (Arabidopsis thaliana, 59.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:121485-125630:- | gene-YBL047C_AKU4011 | rna-NM_001178287.1_AKU4011 | cds-NP_009506.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:112328-116473:- | gene-YBL047C_BG1 | rna-NM_001178287.1_BG1 | cds-NP_009506.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:122090-126235:- | gene-YBL047C_Bruggeman | rna-NM_001178287.1_Bruggeman | cds-NP_009506.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:124722-128867:- | gene-YBL047C_CAT1 | rna-NM_001178287.1_CAT1 | cds-NP_009506.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:114044-118189:- | gene-YBL047C_CBS1585 | rna-NM_001178287.1_CBS1585 | cds-NP_009506.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:122551-126696:- | gene-YBL047C_CBS436 | rna-NM_001178287.1_CBS436 | cds-NP_009506.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:112190-116335:- | gene-YBL047C_CBS6412 | rna-NM_001178287.1_CBS6412 | cds-NP_009506.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:119621-123766:- | gene-YBL047C_CBS6413 | rna-NM_001178287.1_CBS6413 | cds-NP_009506.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:121654-125799:- | gene-YBL047C_CENPK1137D | rna-NM_001178287.1_CENPK1137D | cds-NP_009506.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:135474-139619:- | gene-YBL047C_EthanolRed | rna-NM_001178287.1_EthanolRed | cds-NP_009506.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:136327-140472:- | gene-YBL047C_FaliES1 | rna-NM_001178287.1_FaliES1 | cds-NP_009506.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000072.1:38945-43090:- | gene-YBL047C_JAY291 | rna-NM_001178287.1_JAY291 | cds-NP_009506.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:121466-125611:- | gene-YBL047C_MUCL30387 | rna-NM_001178287.1_MUCL30387 | cds-NP_009506.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:122739-126884:- | gene-YBL047C_MUCL30388 | rna-NM_001178287.1_MUCL30388 | cds-NP_009506.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:114224-118369:- | gene-YBL047C_MUCL39482 | rna-NM_001178287.1_MUCL39482 | cds-NP_009506.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:121057-125202:- | gene-YBL047C_MUCL42920 | rna-NM_001178287.1_MUCL42920 | cds-NP_009506.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:127692-131837:- | gene-YBL047C_NCIM3186 | rna-NM_001178287.1_NCIM3186 | cds-NP_009506.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:115369-119514:- | gene-YBL047C_NCYC1407 | rna-NM_001178287.1_NCYC1407 | cds-NP_009506.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:121622-125767:- | gene-YBL047C_PE2H3 | rna-NM_001178287.1_PE2H3 | cds-NP_009506.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:119266-123411:- | gene-YBL047C_PE2H4 | rna-NM_001178287.1_PE2H4 | cds-NP_009506.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:127895-132040:- | gene-YBL047C_S288C | rna-NM_001178287.1_S288C | cds-NP_009506.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000051.1:12477-16622:- | gene-YBL047C_SA1 | rna-NM_001178287.1_SA1 | cds-NP_009506.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:136288-140433:- | gene-YBL047C_ThermosaccDry | rna-NM_001178287.1_ThermosaccDry | cds-NP_009506.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:118456-122601:- | gene-YBL047C_VR1 | rna-NM_001178287.1_VR1 | cds-NP_009506.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:112995-117142:- | gene-YBL047C_ZTW1 | rna-NM_001178287.1_ZTW1 | cds-NP_009506.1_ZTW1 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:147676-151818:- | gene-YBL047C_Sparadoxus | rna-NM_001178287.1_Sparadoxus | cds-NP_009506.1_Sparadoxus | 88.6 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |