Gene name: ECO1
Reference locus (S288C): YFR027W
Gene biotype: protein_coding
Description: N-acetyltransferase ECO1; Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
Top 10 interactors (score): IRR1 (0.999); PDS5 (0.999); SMC3 (0.999); MCD1 (0.999); SMC1 (0.998); CTF18 (0.998); RAD61 (0.995); ESP1 (0.992); CHL1 (0.991); POL30 (0.983); CTF4 (0.983); SCC2 (0.966); DCC1 (0.952); SMC4 (0.95); CDC28 (0.944); SMC5 (0.939); ELG1 (0.938); SCC4 (0.923); SMC6 (0.91); SMC2 (0.902)
Homologues (species, bitscore): ESCO1 (Homo sapiens, 67.4); Esco1 (Mus musculus, 68.2); esco1 (Danio rerio, 80.9); ESCO1 (Xenopus tropicalis, 70.1); eco (Drosophila melanogaster, 65.5); F08F8.4 (Caenorhabditis elegans, 65.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:197655-198500:+ | gene-YFR027W_AKU4011 | rna-NM_001179992.1_AKU4011 | cds-NP_116683.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000071.1:62629-63474:- | gene-YFR027W_BG1 | rna-NM_001179992.1_BG1 | cds-NP_116683.1_BG1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:201296-202141:+ | gene-YFR027W_Bruggeman | rna-NM_001179992.1_Bruggeman | cds-NP_116683.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:203243-204088:+ | gene-YFR027W_CAT1 | rna-NM_001179992.1_CAT1 | cds-NP_116683.1_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:199146-199991:+ | gene-YFR027W_CBS1585 | rna-NM_001179992.1_CBS1585 | cds-NP_116683.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:172094-172939:+ | gene-YFR027W_CBS436 | rna-NM_001179992.1_CBS436 | cds-NP_116683.1_CBS436 | 98.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:198227-199072:+ | gene-YFR027W_CBS6412 | rna-NM_001179992.1_CBS6412 | cds-NP_116683.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:200882-201727:+ | gene-YFR027W_CBS6413 | rna-NM_001179992.1_CBS6413 | cds-NP_116683.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:203462-204307:+ | gene-YFR027W_CENPK1137D | rna-NM_001179992.1_CENPK1137D | cds-NP_116683.1_CENPK1137D | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:196764-197609:+ | gene-YFR027W_EthanolRed | rna-NM_001179992.1_EthanolRed | cds-NP_116683.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:198414-199259:+ | gene-YFR027W_FaliES1 | rna-NM_001179992.1_FaliES1 | cds-NP_116683.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000453.1:1524-2369:+ | gene-YFR027W_JAY291 | rna-NM_001179992.1_JAY291 | cds-NP_116683.1_JAY291 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:201736-202581:+ | gene-YFR027W_MUCL30387 | rna-NM_001179992.1_MUCL30387 | cds-NP_116683.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:197232-198077:+ | gene-YFR027W_MUCL30388 | rna-NM_001179992.1_MUCL30388 | cds-NP_116683.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:197065-197910:+ | gene-YFR027W_MUCL39482 | rna-NM_001179992.1_MUCL39482 | cds-NP_116683.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:196377-197222:+ | gene-YFR027W_MUCL42920 | rna-NM_001179992.1_MUCL42920 | cds-NP_116683.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:207451-208296:+ | gene-YFR027W_NCIM3186 | rna-NM_001179992.1_NCIM3186 | cds-NP_116683.1_NCIM3186 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:197947-198792:+ | gene-YFR027W_NCYC1407 | rna-NM_001179992.1_NCYC1407 | cds-NP_116683.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:239918-240763:+ | gene-YFR027W_PE2H3 | rna-NM_001179992.1_PE2H3 | cds-NP_116683.1_PE2H3 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:239466-240311:+ | gene-YFR027W_PE2H4 | rna-NM_001179992.1_PE2H4 | cds-NP_116683.1_PE2H4 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:207452-208297:+ | gene-YFR027W_S288C | rna-NM_001179992.1_S288C | cds-NP_116683.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:116171-117016:- | gene-YFR027W_SA1 | rna-NM_001179992.1_SA1 | cds-NP_116683.1_SA1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:197571-198416:+ | gene-YFR027W_ThermosaccDry | rna-NM_001179992.1_ThermosaccDry | cds-NP_116683.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:213309-214154:+ | gene-YFR027W_VR1 | rna-NM_001179992.1_VR1 | cds-NP_116683.1_VR1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:128042-128887:+ | gene-YFR027W_ZTW1 | rna-NM_001179992.1_ZTW1 | cds-NP_116683.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:221198-222043:+ | gene-YFR027W_Sparadoxus | rna-NM_001179992.1_Sparadoxus | cds-NP_116683.1_Sparadoxus | 89.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |