Gene name: DUN1
Reference locus (S288C): YDL101C
Gene biotype: protein_coding
Description: DNA damage response protein kinase DUN1; Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role
Top 10 interactors (score): MIH1 (0.999); MEC1 (0.999); MRC1 (0.998); CHK1 (0.995); MUS81 (0.993); RAD9 (0.992); SML1 (0.992); TEL1 (0.991); RNR1 (0.984); RAD53 (0.983); RNR2 (0.978); RAD24 (0.967); SGS1 (0.966); RFX1 (0.964); RAD51 (0.96); RAD52 (0.958); RAD17 (0.954); MCM5 (0.944); DBF4 (0.935); ASF1 (0.933)
Homologues (species, bitscore): CHEK2 (Homo sapiens, 219.2); Chek2 (Mus musculus, 226.1); si:ch73-60h1.1 (Danio rerio, 217.2); dclk1 (Xenopus tropicalis, 218.0); CG17528 (Drosophila melanogaster, 204.9); cmk-1 (Caenorhabditis elegans, 196.8); SIP4 (Arabidopsis thaliana, 191.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:264915-266456:- | gene-YDL101C_AKU4011 | rna-NM_001180160.1_AKU4011 | cds-NP_010182.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:283485-285026:+ | gene-YDL101C_BG1 | rna-NM_001180160.1_BG1 | cds-NP_010182.1_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:282341-283882:- | gene-YDL101C_Bruggeman | rna-NM_001180160.1_Bruggeman | cds-NP_010182.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:279078-280619:- | gene-YDL101C_CAT1 | rna-NM_001180160.1_CAT1 | cds-NP_010182.1_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:263186-264727:- | gene-YDL101C_CBS1585 | rna-NM_001180160.1_CBS1585 | cds-NP_010182.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:279856-281397:- | gene-YDL101C_CBS436 | rna-NM_001180160.1_CBS436 | cds-NP_010182.1_CBS436 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:261614-263155:- | gene-YDL101C_CBS6412 | rna-NM_001180160.1_CBS6412 | cds-NP_010182.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:281239-282780:- | gene-YDL101C_CBS6413 | rna-NM_001180160.1_CBS6413 | cds-NP_010182.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:279112-280653:- | gene-YDL101C_CENPK1137D | rna-NM_001180160.1_CENPK1137D | cds-NP_010182.1_CENPK1137D | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:275948-277489:- | gene-YDL101C_EthanolRed | rna-NM_001180160.1_EthanolRed | cds-NP_010182.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:281920-283461:- | gene-YDL101C_FaliES1 | rna-NM_001180160.1_FaliES1 | cds-NP_010182.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:51973-53514:- | gene-YDL101C_JAY291 | rna-NM_001180160.1_JAY291 | cds-NP_010182.1_JAY291 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:280104-281645:- | gene-YDL101C_MUCL30387 | rna-NM_001180160.1_MUCL30387 | cds-NP_010182.1_MUCL30387 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:270879-272420:- | gene-YDL101C_MUCL30388 | rna-NM_001180160.1_MUCL30388 | cds-NP_010182.1_MUCL30388 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:264292-265833:- | gene-YDL101C_MUCL39482 | rna-NM_001180160.1_MUCL39482 | cds-NP_010182.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:186060-187601:- | gene-YDL101C_MUCL42920 | rna-NM_001180160.1_MUCL42920 | cds-NP_010182.1_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:280230-281771:- | gene-YDL101C_NCIM3186 | rna-NM_001180160.1_NCIM3186 | cds-NP_010182.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:264307-265848:- | gene-YDL101C_NCYC1407 | rna-NM_001180160.1_NCYC1407 | cds-NP_010182.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:271090-272631:- | gene-YDL101C_PE2H3 | rna-NM_001180160.1_PE2H3 | cds-NP_010182.1_PE2H3 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:271091-272632:- | gene-YDL101C_PE2H4 | rna-NM_001180160.1_PE2H4 | cds-NP_010182.1_PE2H4 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:280307-281848:- | gene-YDL101C_S288C | rna-NM_001180160.1_S288C | cds-NP_010182.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:153074-154615:+ | gene-YDL101C_SA1 | rna-NM_001180160.1_SA1 | cds-NP_010182.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:281431-282972:- | gene-YDL101C_ThermosaccDry | rna-NM_001180160.1_ThermosaccDry | cds-NP_010182.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:283509-285050:- | gene-YDL101C_VR1 | rna-NM_001180160.1_VR1 | cds-NP_010182.1_VR1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:279356-280897:- | gene-YDL101C_ZTW1 | rna-NM_001180160.1_ZTW1 | cds-NP_010182.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:281478-283019:- | gene-YDL101C_Sparadoxus | rna-NM_001180160.1_Sparadoxus | cds-NP_010182.1_Sparadoxus | 91.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |