Gene name: DUG1
Reference locus (S288C): YFR044C
Gene biotype: protein_coding
Description: Cys-Gly metallodipeptidase DUG1; Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant
Top 10 interactors (score): DUG3 (0.998); ECM38 (0.984); PRX1 (0.964); YPL225W (0.962); DUG2 (0.951); GSH2 (0.927); GSH1 (0.914); GCG1 (0.9); RBK1 (0.9); BAT2 (0.876); SHM2 (0.874); MET17 (0.861); ERG10 (0.855); BAT1 (0.852); ECM10 (0.85); HAM1 (0.848); MCY1 (0.846); SSC1 (0.84); ARG5,6 (0.84); SHM1 (0.839)
Homologues (species, bitscore): CNDP2 (Homo sapiens, 493.8); Cndp2 (Mus musculus, 493.4); cndp2 (Danio rerio, 489.2); cndp2 (Xenopus tropicalis, 421.0); CG17337 (Drosophila melanogaster, 424.9); pes-9 (Caenorhabditis elegans, 431.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:230141-231586:- | gene-YFR044C_AKU4011 | rna-NM_001180009.1_AKU4011 | cds-NP_116702.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000071.1:29425-30870:+ | gene-YFR044C_BG1 | rna-NM_001180009.1_BG1 | cds-NP_116702.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:233797-235242:- | gene-YFR044C_Bruggeman | rna-NM_001180009.1_Bruggeman | cds-NP_116702.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:235765-237210:- | gene-YFR044C_CAT1 | rna-NM_001180009.1_CAT1 | cds-NP_116702.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:231641-233086:- | gene-YFR044C_CBS1585 | rna-NM_001180009.1_CBS1585 | cds-NP_116702.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:204600-206045:- | gene-YFR044C_CBS436 | rna-NM_001180009.1_CBS436 | cds-NP_116702.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:230716-232161:- | gene-YFR044C_CBS6412 | rna-NM_001180009.1_CBS6412 | cds-NP_116702.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:233389-234834:- | gene-YFR044C_CBS6413 | rna-NM_001180009.1_CBS6413 | cds-NP_116702.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:236081-237526:- | gene-YFR044C_CENPK1137D | rna-NM_001180009.1_CENPK1137D | cds-NP_116702.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:229259-230704:- | gene-YFR044C_EthanolRed | rna-NM_001180009.1_EthanolRed | cds-NP_116702.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:230909-232354:- | gene-YFR044C_FaliES1 | rna-NM_001180009.1_FaliES1 | cds-NP_116702.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000453.1:34038-35483:- | gene-YFR044C_JAY291 | rna-NM_001180009.1_JAY291 | cds-NP_116702.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:234246-235691:- | gene-YFR044C_MUCL30387 | rna-NM_001180009.1_MUCL30387 | cds-NP_116702.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:229726-231171:- | gene-YFR044C_MUCL30388 | rna-NM_001180009.1_MUCL30388 | cds-NP_116702.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:229563-231008:- | gene-YFR044C_MUCL39482 | rna-NM_001180009.1_MUCL39482 | cds-NP_116702.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:229163-230608:- | gene-YFR044C_MUCL42920 | rna-NM_001180009.1_MUCL42920 | cds-NP_116702.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:239991-241436:- | gene-YFR044C_NCIM3186 | rna-NM_001180009.1_NCIM3186 | cds-NP_116702.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:230413-231858:- | gene-YFR044C_NCYC1407 | rna-NM_001180009.1_NCYC1407 | cds-NP_116702.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:272448-273893:- | gene-YFR044C_PE2H3 | rna-NM_001180009.1_PE2H3 | cds-NP_116702.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:271996-273441:- | gene-YFR044C_PE2H4 | rna-NM_001180009.1_PE2H4 | cds-NP_116702.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:239992-241437:- | gene-YFR044C_S288C | rna-NM_001180009.1_S288C | cds-NP_116702.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000086.1:29668-31113:+ | gene-YFR044C_SA1 | rna-NM_001180009.1_SA1 | cds-NP_116702.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:230078-231523:- | gene-YFR044C_ThermosaccDry | rna-NM_001180009.1_ThermosaccDry | cds-NP_116702.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:245830-247275:- | gene-YFR044C_VR1 | rna-NM_001180009.1_VR1 | cds-NP_116702.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:160527-161972:- | gene-YFR044C_ZTW1 | rna-NM_001180009.1_ZTW1 | cds-NP_116702.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:253576-255021:- | gene-YFR044C_Sparadoxus | rna-NM_001180009.1_Sparadoxus | cds-NP_116702.1_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |