Gene name: DRS2
Reference locus (S288C): YAL026C
Gene biotype: protein_coding
Description: Probable phospholipid-transporting ATPase DRS2; Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily
Top 10 interactors (score): CDC50 (0.999); LEM3 (0.997); DNF1 (0.98); GEA2 (0.965); RCY1 (0.93); KES1 (0.901); NEO1 (0.874); SMI1 (0.856); SNC1 (0.85); SEC7 (0.823); YPT31 (0.762); ARF1 (0.758); ARL1 (0.741); PIK1 (0.736); KEX2 (0.717); ANY1 (0.71); YNR048W (0.692); CHO1 (0.688); FLC2 (0.681); PIN2 (0.665)
Homologues (species, bitscore): ATP8A1 (Homo sapiens, 1015.0); Atp8a1 (Mus musculus, 1025.4); atp8a2 (Danio rerio, 995.0); atp8a1 (Xenopus tropicalis, 887.5); CG42321 (Drosophila melanogaster, 974.9); tat-1 (Caenorhabditis elegans, 832.8); ALA3 (Arabidopsis thaliana, 898.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005295.1:80756-84823:- | gene-YAL026C_AKU4011 | rna-NM_001178171.2_AKU4011 | cds-NP_009376.2_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000070.1:67883-71950:- | gene-YAL026C_BG1 | rna-NM_001178171.2_BG1 | cds-NP_009376.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005503.1:95635-99702:- | gene-YAL026C_Bruggeman | rna-NM_001178171.2_Bruggeman | cds-NP_009376.2_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005519.1:81982-86049:- | gene-YAL026C_CAT1 | rna-NM_001178171.2_CAT1 | cds-NP_009376.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005359.1:93774-97841:- | gene-YAL026C_CBS1585 | rna-NM_001178171.2_CBS1585 | cds-NP_009376.2_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005343.1:94022-98089:- | gene-YAL026C_CBS436 | rna-NM_001178171.2_CBS436 | cds-NP_009376.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005327.1:79919-83986:- | gene-YAL026C_CBS6412 | rna-NM_001178171.2_CBS6412 | cds-NP_009376.2_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005311.1:92038-96105:- | gene-YAL026C_CBS6413 | rna-NM_001178171.2_CBS6413 | cds-NP_009376.2_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001522.1:95720-99787:- | gene-YAL026C_CENPK1137D | rna-NM_001178171.2_CENPK1137D | cds-NP_009376.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005471.1:82178-86245:- | gene-YAL026C_EthanolRed | rna-NM_001178171.2_EthanolRed | cds-NP_009376.2_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005535.1:96801-100868:- | gene-YAL026C_FaliES1 | rna-NM_001178171.2_FaliES1 | cds-NP_009376.2_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000084.1:68072-72139:- | gene-YAL026C_JAY291 | rna-NM_001178171.2_JAY291 | cds-NP_009376.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005407.1:96727-100794:- | gene-YAL026C_MUCL30387 | rna-NM_001178171.2_MUCL30387 | cds-NP_009376.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005439.1:93274-97341:- | gene-YAL026C_MUCL30388 | rna-NM_001178171.2_MUCL30388 | cds-NP_009376.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005279.1:92560-96627:- | gene-YAL026C_MUCL39482 | rna-NM_001178171.2_MUCL39482 | cds-NP_009376.2_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005423.1:94931-98998:- | gene-YAL026C_MUCL42920 | rna-NM_001178171.2_MUCL42920 | cds-NP_009376.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011810.1:95507-99574:- | gene-YAL026C_NCIM3186 | rna-NM_001178171.2_NCIM3186 | cds-NP_009376.2_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005263.1:80438-84505:- | gene-YAL026C_NCYC1407 | rna-NM_001178171.2_NCYC1407 | cds-NP_009376.2_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994140.1:82348-86415:- | gene-YAL026C_PE2H3 | rna-NM_001178171.2_PE2H3 | cds-NP_009376.2_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999872.1:82067-86134:- | gene-YAL026C_PE2H4 | rna-NM_001178171.2_PE2H4 | cds-NP_009376.2_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001133.9:95630-99697:- | gene-YAL026C_S288C | rna-NM_001178171.2_S288C | cds-NP_009376.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000059.1:24753-28820:- | gene-YAL026C_SA1 | rna-NM_001178171.2_SA1 | cds-NP_009376.2_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005487.1:96319-100386:- | gene-YAL026C_ThermosaccDry | rna-NM_001178171.2_ThermosaccDry | cds-NP_009376.2_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005455.1:97598-101665:- | gene-YAL026C_VR1 | rna-NM_001178171.2_VR1 | cds-NP_009376.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:68134-72201:- | gene-YAL026C_ZTW1 | rna-NM_001178171.2_ZTW1 | cds-NP_009376.2_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047487.1:85767-89834:- | gene-YAL026C_Sparadoxus | rna-NM_001178171.2_Sparadoxus | cds-NP_009376.2_Sparadoxus | 92.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |