Gene name: DPH6
Reference locus (S288C): YLR143W
Gene biotype: protein_coding
Description: Diphthine--ammonia ligase; Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene; In the C-terminal section; belongs to the RutC family
Top 10 interactors (score): RRT2 (0.999); DPH5 (0.994); DPH1 (0.992); DPH2 (0.99); KTI11 (0.98); JJJ3 (0.954); ELP2 (0.951); EFT2 (0.924); HMF1 (0.919); NOP4 (0.907); EFT1 (0.865); GUA1 (0.784); VPS30 (0.761); LEA1 (0.758); TRM8 (0.713); ATS1 (0.713); BUD23 (0.709); RMP1 (0.698); NCS2 (0.693); KSP1 (0.687)
Homologues (species, bitscore): DPH6 (Homo sapiens, 223.4); Dph6 (Mus musculus, 226.1); dph6 (Danio rerio, 267.7); dph6 (Xenopus tropicalis, 285.8); CG1578 (Drosophila melanogaster, 255.4); E01A2.5 (Caenorhabditis elegans, 211.8); AT3G04480 (Arabidopsis thaliana, 271.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:409809-411866:+ | gene-YLR143W_AKU4011 | rna-NM_001182030.1_AKU4011 | cds-NP_013244.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:373580-375637:+ | gene-YLR143W_BG1 | rna-NM_001182030.1_BG1 | cds-NP_013244.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:421705-423762:+ | gene-YLR143W_Bruggeman | rna-NM_001182030.1_Bruggeman | cds-NP_013244.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:421090-423147:+ | gene-YLR143W_CAT1 | rna-NM_001182030.1_CAT1 | cds-NP_013244.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:416952-419009:+ | gene-YLR143W_CBS1585 | rna-NM_001182030.1_CBS1585 | cds-NP_013244.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:407189-409246:+ | gene-YLR143W_CBS436 | rna-NM_001182030.1_CBS436 | cds-NP_013244.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:415370-417427:+ | gene-YLR143W_CBS6412 | rna-NM_001182030.1_CBS6412 | cds-NP_013244.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:417217-419274:+ | gene-YLR143W_CBS6413 | rna-NM_001182030.1_CBS6413 | cds-NP_013244.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:412347-414404:+ | gene-YLR143W_CENPK1137D | rna-NM_001182030.1_CENPK1137D | cds-NP_013244.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:410010-412067:+ | gene-YLR143W_EthanolRed | rna-NM_001182030.1_EthanolRed | cds-NP_013244.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:409521-411578:+ | gene-YLR143W_FaliES1 | rna-NM_001182030.1_FaliES1 | cds-NP_013244.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000061.1:16181-18238:+ | gene-YLR143W_JAY291 | rna-NM_001182030.1_JAY291 | cds-NP_013244.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:421710-423767:+ | gene-YLR143W_MUCL30387 | rna-NM_001182030.1_MUCL30387 | cds-NP_013244.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:426510-428567:+ | gene-YLR143W_MUCL30388 | rna-NM_001182030.1_MUCL30388 | cds-NP_013244.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:417461-419518:+ | gene-YLR143W_MUCL39482 | rna-NM_001182030.1_MUCL39482 | cds-NP_013244.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:417615-419672:+ | gene-YLR143W_MUCL42920 | rna-NM_001182030.1_MUCL42920 | cds-NP_013244.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:427303-429360:+ | gene-YLR143W_NCIM3186 | rna-NM_001182030.1_NCIM3186 | cds-NP_013244.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:409733-411790:+ | gene-YLR143W_NCYC1407 | rna-NM_001182030.1_NCYC1407 | cds-NP_013244.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:415290-417347:+ | gene-YLR143W_PE2H3 | rna-NM_001182030.1_PE2H3 | cds-NP_013244.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:415031-417088:+ | gene-YLR143W_PE2H4 | rna-NM_001182030.1_PE2H4 | cds-NP_013244.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:427329-429386:+ | gene-YLR143W_S288C | rna-NM_001182030.1_S288C | cds-NP_013244.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000055.1:53226-55283:+ | gene-YLR143W_SA1 | rna-NM_001182030.1_SA1 | cds-NP_013244.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:410731-412788:+ | gene-YLR143W_ThermosaccDry | rna-NM_001182030.1_ThermosaccDry | cds-NP_013244.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:423431-425488:+ | gene-YLR143W_VR1 | rna-NM_001182030.1_VR1 | cds-NP_013244.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:408517-410574:+ | gene-YLR143W_ZTW1 | rna-NM_001182030.1_ZTW1 | cds-NP_013244.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:418635-420695:+ | gene-YLR143W_Sparadoxus | rna-NM_001182030.1_Sparadoxus | cds-NP_013244.1_Sparadoxus | 85.1 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |