Gene name: DPH5
Reference locus (S288C): YLR172C
Gene biotype: protein_coding
Description: Diphthine methyl ester synthase; Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; Belongs to the diphthine synthase family
Top 10 interactors (score): DPH2 (0.999); DPH1 (0.999); RRT2 (0.998); KTI11 (0.998); DPH6 (0.994); EFT2 (0.991); MEU1 (0.968); EFT1 (0.967); JJJ3 (0.948); RCL1 (0.94); ELP2 (0.926); RPF2 (0.907); SNU13 (0.907); NOP56 (0.906); NHP2 (0.904); NIP7 (0.904); MRT4 (0.901); YTM1 (0.899); BRX1 (0.897); TSR2 (0.896)
Homologues (species, bitscore): DPH5 (Homo sapiens, 329.7); Dph5 (Mus musculus, 329.3); dph5 (Danio rerio, 340.9); dph5 (Xenopus tropicalis, 314.7); Dph5 (Drosophila melanogaster, 297.0); B0491.7 (Caenorhabditis elegans, 308.5); AT4G31790 (Arabidopsis thaliana, 311.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:455363-456265:- | gene-YLR172C_AKU4011 | rna-NM_001182059.1_AKU4011 | cds-NP_013273.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000177.1:12591-13493:- | gene-YLR172C_BG1 | rna-NM_001182059.1_BG1 | cds-NP_013273.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:495704-496606:- | gene-YLR172C_Bruggeman | rna-NM_001182059.1_Bruggeman | cds-NP_013273.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:495234-496136:- | gene-YLR172C_CAT1 | rna-NM_001182059.1_CAT1 | cds-NP_013273.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:490860-491762:- | gene-YLR172C_CBS1585 | rna-NM_001182059.1_CBS1585 | cds-NP_013273.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:481000-481902:- | gene-YLR172C_CBS436 | rna-NM_001182059.1_CBS436 | cds-NP_013273.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:459431-460333:- | gene-YLR172C_CBS6412 | rna-NM_001182059.1_CBS6412 | cds-NP_013273.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:491166-492068:- | gene-YLR172C_CBS6413 | rna-NM_001182059.1_CBS6413 | cds-NP_013273.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:485977-486879:- | gene-YLR172C_CENPK1137D | rna-NM_001182059.1_CENPK1137D | cds-NP_013273.1_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:454884-455786:- | gene-YLR172C_EthanolRed | rna-NM_001182059.1_EthanolRed | cds-NP_013273.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:483811-484713:- | gene-YLR172C_FaliES1 | rna-NM_001182059.1_FaliES1 | cds-NP_013273.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000004.1:10744-11646:- | gene-YLR172C_JAY291 | rna-NM_001182059.1_JAY291 | cds-NP_013273.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:495725-496627:- | gene-YLR172C_MUCL30387 | rna-NM_001182059.1_MUCL30387 | cds-NP_013273.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:500657-501559:- | gene-YLR172C_MUCL30388 | rna-NM_001182059.1_MUCL30388 | cds-NP_013273.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:491857-492759:- | gene-YLR172C_MUCL39482 | rna-NM_001182059.1_MUCL39482 | cds-NP_013273.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:492429-493331:- | gene-YLR172C_MUCL42920 | rna-NM_001182059.1_MUCL42920 | cds-NP_013273.1_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:501234-502136:- | gene-YLR172C_NCIM3186 | rna-NM_001182059.1_NCIM3186 | cds-NP_013273.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:484281-485183:- | gene-YLR172C_NCYC1407 | rna-NM_001182059.1_NCYC1407 | cds-NP_013273.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:488531-489433:- | gene-YLR172C_PE2H3 | rna-NM_001182059.1_PE2H3 | cds-NP_013273.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:488275-489177:- | gene-YLR172C_PE2H4 | rna-NM_001182059.1_PE2H4 | cds-NP_013273.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:501260-502162:- | gene-YLR172C_S288C | rna-NM_001182059.1_S288C | cds-NP_013273.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000042.1:10802-11704:- | gene-YLR172C_SA1 | rna-NM_001182059.1_SA1 | cds-NP_013273.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:486335-487237:- | gene-YLR172C_ThermosaccDry | rna-NM_001182059.1_ThermosaccDry | cds-NP_013273.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:497644-498546:- | gene-YLR172C_VR1 | rna-NM_001182059.1_VR1 | cds-NP_013273.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:10704-11606:- | gene-YLR172C_ZTW1 | rna-NM_001182059.1_ZTW1 | cds-NP_013273.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:472361-473263:- | gene-YLR172C_Sparadoxus | rna-NM_001182059.1_Sparadoxus | cds-NP_013273.1_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |