Gene name: DPH2
Reference locus (S288C): YKL191W
Gene biotype: protein_coding
Description: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
Top 10 interactors (score): DPH1 (0.999); DPH5 (0.999); KTI11 (0.999); RRT2 (0.994); EFT2 (0.992); DPH6 (0.99); EFT1 (0.968); JJJ3 (0.946); ELP2 (0.902); MTR4 (0.795); ATS1 (0.776); DHR2 (0.772); ELP3 (0.753); DIM1 (0.751); DBP9 (0.737); COQ5 (0.736); NOC4 (0.732); HMF1 (0.709); SEC53 (0.706); YTM1 (0.698)
Homologues (species, bitscore): DPH2 (Homo sapiens, 133.3); Dph2 (Mus musculus, 141.4); dph2 (Danio rerio, 203.4); dph2 (Xenopus tropicalis, 196.1); CG7265 (Drosophila melanogaster, 147.1); dph-2 (Caenorhabditis elegans, 128.6); AT3G59630 (Arabidopsis thaliana, 174.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:67396-69000:+ | gene-YKL191W_AKU4011 | rna-NM_001179757.1_AKU4011 | cds-NP_012730.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:44411-46015:+ | gene-YKL191W_BG1 | rna-NM_001179757.1_BG1 | cds-NP_012730.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:85269-86873:+ | gene-YKL191W_Bruggeman | rna-NM_001179757.1_Bruggeman | cds-NP_012730.1_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:80230-81834:+ | gene-YKL191W_CAT1 | rna-NM_001179757.1_CAT1 | cds-NP_012730.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:79380-80984:+ | gene-YKL191W_CBS1585 | rna-NM_001179757.1_CBS1585 | cds-NP_012730.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:78625-80229:+ | gene-YKL191W_CBS436 | rna-NM_001179757.1_CBS436 | cds-NP_012730.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:64633-66237:+ | gene-YKL191W_CBS6412 | rna-NM_001179757.1_CBS6412 | cds-NP_012730.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:80042-81646:+ | gene-YKL191W_CBS6413 | rna-NM_001179757.1_CBS6413 | cds-NP_012730.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:80864-82468:+ | gene-YKL191W_CENPK1137D | rna-NM_001179757.1_CENPK1137D | cds-NP_012730.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:78658-80262:+ | gene-YKL191W_EthanolRed | rna-NM_001179757.1_EthanolRed | cds-NP_012730.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:78938-80542:+ | gene-YKL191W_FaliES1 | rna-NM_001179757.1_FaliES1 | cds-NP_012730.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:78457-80061:+ | gene-YKL191W_JAY291 | rna-NM_001179757.1_JAY291 | cds-NP_012730.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:87570-89174:+ | gene-YKL191W_MUCL30387 | rna-NM_001179757.1_MUCL30387 | cds-NP_012730.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:81667-83271:+ | gene-YKL191W_MUCL30388 | rna-NM_001179757.1_MUCL30388 | cds-NP_012730.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:79437-81041:+ | gene-YKL191W_MUCL39482 | rna-NM_001179757.1_MUCL39482 | cds-NP_012730.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:82995-84599:+ | gene-YKL191W_MUCL42920 | rna-NM_001179757.1_MUCL42920 | cds-NP_012730.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:81024-82628:+ | gene-YKL191W_NCIM3186 | rna-NM_001179757.1_NCIM3186 | cds-NP_012730.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:79462-81066:+ | gene-YKL191W_NCYC1407 | rna-NM_001179757.1_NCYC1407 | cds-NP_012730.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:86998-88602:+ | gene-YKL191W_PE2H3 | rna-NM_001179757.1_PE2H3 | cds-NP_012730.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:83292-84896:+ | gene-YKL191W_PE2H4 | rna-NM_001179757.1_PE2H4 | cds-NP_012730.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:81035-82639:+ | gene-YKL191W_S288C | rna-NM_001179757.1_S288C | cds-NP_012730.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000113.1:14912-16516:+ | gene-YKL191W_SA1 | rna-NM_001179757.1_SA1 | cds-NP_012730.1_SA1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:79640-81244:+ | gene-YKL191W_ThermosaccDry | rna-NM_001179757.1_ThermosaccDry | cds-NP_012730.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:78704-80308:+ | gene-YKL191W_VR1 | rna-NM_001179757.1_VR1 | cds-NP_012730.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:78575-80179:+ | gene-YKL191W_ZTW1 | rna-NM_001179757.1_ZTW1 | cds-NP_012730.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:92832-94436:+ | gene-YKL191W_Sparadoxus | rna-NM_001179757.1_Sparadoxus | cds-NP_012730.1_Sparadoxus | 87.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |