Gene name: DPB11
Reference locus (S288C): YJL090C
Gene biotype: protein_coding
Description: DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
Top 10 interactors (score): RTT107 (0.999); MEC1 (0.999); SLD3 (0.999); RAD9 (0.999); MCM2 (0.999); SLD2 (0.999); CDC45 (0.999); MCM10 (0.998); DDC1 (0.998); PSF1 (0.997); SLD5 (0.997); MCM4 (0.997); DPB2 (0.996); CDC6 (0.996); PSF3 (0.996); CHK1 (0.995); PSF2 (0.993); RAD17 (0.992); RAD24 (0.992); SLD7 (0.991)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:245477-247771:- | gene-YJL090C_AKU4011 | rna-NM_001181523.1_AKU4011 | cds-NP_012445.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:366682-368976:+ | gene-YJL090C_BG1 | rna-NM_001181523.1_BG1 | cds-NP_012445.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:256922-259216:- | gene-YJL090C_Bruggeman | rna-NM_001181523.1_Bruggeman | cds-NP_012445.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:261819-264113:- | gene-YJL090C_CAT1 | rna-NM_001181523.1_CAT1 | cds-NP_012445.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:257138-259432:- | gene-YJL090C_CBS1585 | rna-NM_001181523.1_CBS1585 | cds-NP_012445.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:275246-277540:- | gene-YJL090C_CBS436 | rna-NM_001181523.1_CBS436 | cds-NP_012445.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:246235-248529:- | gene-YJL090C_CBS6412 | rna-NM_001181523.1_CBS6412 | cds-NP_012445.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:247590-249884:- | gene-YJL090C_CBS6413 | rna-NM_001181523.1_CBS6413 | cds-NP_012445.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:245228-247522:- | gene-YJL090C_CENPK1137D | rna-NM_001181523.1_CENPK1137D | cds-NP_012445.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:249324-251618:- | gene-YJL090C_EthanolRed | rna-NM_001181523.1_EthanolRed | cds-NP_012445.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:260898-263192:- | gene-YJL090C_FaliES1 | rna-NM_001181523.1_FaliES1 | cds-NP_012445.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000138.1:58519-60813:- | gene-YJL090C_JAY291 | rna-NM_001181523.1_JAY291 | cds-NP_012445.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:259192-261486:- | gene-YJL090C_MUCL30387 | rna-NM_001181523.1_MUCL30387 | cds-NP_012445.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:255267-257561:- | gene-YJL090C_MUCL30388 | rna-NM_001181523.1_MUCL30388 | cds-NP_012445.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:249895-252189:- | gene-YJL090C_MUCL39482 | rna-NM_001181523.1_MUCL39482 | cds-NP_012445.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:256100-258394:- | gene-YJL090C_MUCL42920 | rna-NM_001181523.1_MUCL42920 | cds-NP_012445.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:262736-265030:- | gene-YJL090C_NCIM3186 | rna-NM_001181523.1_NCIM3186 | cds-NP_012445.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:248583-250877:- | gene-YJL090C_NCYC1407 | rna-NM_001181523.1_NCYC1407 | cds-NP_012445.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:260945-263239:- | gene-YJL090C_PE2H3 | rna-NM_001181523.1_PE2H3 | cds-NP_012445.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:260589-262883:- | gene-YJL090C_PE2H4 | rna-NM_001181523.1_PE2H4 | cds-NP_012445.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:262757-265051:- | gene-YJL090C_S288C | rna-NM_001181523.1_S288C | cds-NP_012445.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000003.1:58460-60754:- | gene-YJL090C_SA1 | rna-NM_001181523.1_SA1 | cds-NP_012445.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:254310-256604:- | gene-YJL090C_ThermosaccDry | rna-NM_001181523.1_ThermosaccDry | cds-NP_012445.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:255820-258114:- | gene-YJL090C_VR1 | rna-NM_001181523.1_VR1 | cds-NP_012445.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:235671-237965:- | gene-YJL090C_ZTW1 | rna-NM_001181523.1_ZTW1 | cds-NP_012445.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:259775-262066:- | gene-YJL090C_Sparadoxus | rna-NM_001181523.1_Sparadoxus | cds-NP_012445.1_Sparadoxus | 87.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |