Gene name: DOT1
Reference locus (S288C): YDR440W
Gene biotype: protein_coding
Description: Histone-lysine N-methyltransferase, H3 lysine-79 specific; Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
Top 10 interactors (score): SET1 (0.999); SET2 (0.999); HHT2 (0.997); HHT1 (0.996); HHF1 (0.995); BRE1 (0.987); SIR3 (0.978); SIR2 (0.968); HHF2 (0.964); HTB2 (0.954); HTB1 (0.954); RAD6 (0.952); PCH2 (0.918); SAS2 (0.913); CTM1 (0.91); HTA2 (0.907); HTA1 (0.893); SWD2 (0.889); ZIP1 (0.888); GCN5 (0.882)
Homologues (species, bitscore): DOT1L (Homo sapiens, 115.2); Dot1l (Mus musculus, 116.7); dot1l (Danio rerio, 120.2); dot1l (Xenopus tropicalis, 119.0); gpp (Drosophila melanogaster, 90.1); F54F7.7 (Caenorhabditis elegans, 87.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1282741-1284489:+ | gene-YDR440W_AKU4011 | rna-NM_001180748.1_AKU4011 | cds-NP_010728.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:161097-162845:+ | gene-YDR440W_BG1 | rna-NM_001180748.1_BG1 | cds-NP_010728.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1313373-1315121:+ | gene-YDR440W_Bruggeman | rna-NM_001180748.1_Bruggeman | cds-NP_010728.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1291334-1293082:+ | gene-YDR440W_CAT1 | rna-NM_001180748.1_CAT1 | cds-NP_010728.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1277048-1278796:+ | gene-YDR440W_CBS1585 | rna-NM_001180748.1_CBS1585 | cds-NP_010728.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1296418-1298166:+ | gene-YDR440W_CBS436 | rna-NM_001180748.1_CBS436 | cds-NP_010728.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1272686-1274434:+ | gene-YDR440W_CBS6412 | rna-NM_001180748.1_CBS6412 | cds-NP_010728.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1295200-1296948:+ | gene-YDR440W_CBS6413 | rna-NM_001180748.1_CBS6413 | cds-NP_010728.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1341171-1342919:+ | gene-YDR440W_CENPK1137D | rna-NM_001180748.1_CENPK1137D | cds-NP_010728.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1286111-1287859:+ | gene-YDR440W_EthanolRed | rna-NM_001180748.1_EthanolRed | cds-NP_010728.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1289662-1291410:+ | gene-YDR440W_FaliES1 | rna-NM_001180748.1_FaliES1 | cds-NP_010728.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000263.1:33901-35649:+ | gene-YDR440W_JAY291 | rna-NM_001180748.1_JAY291 | cds-NP_010728.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1296786-1298534:+ | gene-YDR440W_MUCL30387 | rna-NM_001180748.1_MUCL30387 | cds-NP_010728.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1278699-1280447:+ | gene-YDR440W_MUCL30388 | rna-NM_001180748.1_MUCL30388 | cds-NP_010728.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1268539-1270287:+ | gene-YDR440W_MUCL39482 | rna-NM_001180748.1_MUCL39482 | cds-NP_010728.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1210978-1212726:+ | gene-YDR440W_MUCL42920 | rna-NM_001180748.1_MUCL42920 | cds-NP_010728.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1342416-1344164:+ | gene-YDR440W_NCIM3186 | rna-NM_001180748.1_NCIM3186 | cds-NP_010728.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1282304-1284052:+ | gene-YDR440W_NCYC1407 | rna-NM_001180748.1_NCYC1407 | cds-NP_010728.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1293144-1294892:+ | gene-YDR440W_PE2H3 | rna-NM_001180748.1_PE2H3 | cds-NP_010728.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1298712-1300460:+ | gene-YDR440W_PE2H4 | rna-NM_001180748.1_PE2H4 | cds-NP_010728.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1342493-1344241:+ | gene-YDR440W_S288C | rna-NM_001180748.1_S288C | cds-NP_010728.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000082.1:12980-14728:- | gene-YDR440W_SA1 | rna-NM_001180748.1_SA1 | cds-NP_010728.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1293886-1295634:+ | gene-YDR440W_ThermosaccDry | rna-NM_001180748.1_ThermosaccDry | cds-NP_010728.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1309125-1310873:+ | gene-YDR440W_VR1 | rna-NM_001180748.1_VR1 | cds-NP_010728.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:336542-338290:+ | gene-YDR440W_ZTW1 | rna-NM_001180748.1_ZTW1 | cds-NP_010728.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1290478-1292232:+ | gene-YDR440W_Sparadoxus | rna-NM_001180748.1_Sparadoxus | cds-NP_010728.1_Sparadoxus | 87.5 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |