Gene name: DOM34
Reference locus (S288C): YNL001W
Gene biotype: protein_coding
Description: Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
Top 10 interactors (score): RLI1 (0.999); HBS1 (0.999); SKI7 (0.999); SUP35 (0.997); ASC1 (0.989); SKI2 (0.987); RPS23A (0.981); RPS20 (0.979); RKR1 (0.977); SUP45 (0.963); RPS3 (0.957); RPS31 (0.957); RQC2 (0.955); RPS10A (0.954); RPS30A (0.954); RPS6B (0.942); RPS1A (0.938); RPS18B (0.937); RPS15 (0.937); RPS17B (0.937)
Homologues (species, bitscore): PELO (Homo sapiens, 255.8); Pelo (Mus musculus, 252.3); pelo (Danio rerio, 229.2); pelo (Xenopus tropicalis, 213.4); pelo (Drosophila melanogaster, 241.1); R74.6 (Caenorhabditis elegans, 204.5); PEL1 (Arabidopsis thaliana, 202.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:610556-611716:+ | gene-YNL001W_AKU4011 | rna-NM_001182840.1_AKU4011 | cds-NP_014397.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:512985-514145:+ | gene-YNL001W_BG1 | rna-NM_001182840.1_BG1 | cds-NP_014397.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:627374-628534:+ | gene-YNL001W_Bruggeman | rna-NM_001182840.1_Bruggeman | cds-NP_014397.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:662757-663917:+ | gene-YNL001W_CAT1 | rna-NM_001182840.1_CAT1 | cds-NP_014397.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:616253-617413:+ | gene-YNL001W_CBS1585 | rna-NM_001182840.1_CBS1585 | cds-NP_014397.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:678275-679435:+ | gene-YNL001W_CBS436 | rna-NM_001182840.1_CBS436 | cds-NP_014397.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:606061-607221:+ | gene-YNL001W_CBS6412 | rna-NM_001182840.1_CBS6412 | cds-NP_014397.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:607224-608384:+ | gene-YNL001W_CBS6413 | rna-NM_001182840.1_CBS6413 | cds-NP_014397.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:621106-622266:+ | gene-YNL001W_CENPK1137D | rna-NM_001182840.1_CENPK1137D | cds-NP_014397.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:612623-613783:+ | gene-YNL001W_EthanolRed | rna-NM_001182840.1_EthanolRed | cds-NP_014397.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:603392-604552:+ | gene-YNL001W_FaliES1 | rna-NM_001182840.1_FaliES1 | cds-NP_014397.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000008.1:3428-4588:- | gene-YNL001W_JAY291 | rna-NM_001182840.1_JAY291 | cds-NP_014397.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:625463-626623:+ | gene-YNL001W_MUCL30387 | rna-NM_001182840.1_MUCL30387 | cds-NP_014397.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:666293-667453:+ | gene-YNL001W_MUCL30388 | rna-NM_001182840.1_MUCL30388 | cds-NP_014397.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:607761-608921:+ | gene-YNL001W_MUCL39482 | rna-NM_001182840.1_MUCL39482 | cds-NP_014397.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:611557-612717:+ | gene-YNL001W_MUCL42920 | rna-NM_001182840.1_MUCL42920 | cds-NP_014397.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:627425-628585:+ | gene-YNL001W_NCIM3186 | rna-NM_001182840.1_NCIM3186 | cds-NP_014397.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:610014-611174:+ | gene-YNL001W_NCYC1407 | rna-NM_001182840.1_NCYC1407 | cds-NP_014397.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:611935-613095:+ | gene-YNL001W_PE2H3 | rna-NM_001182840.1_PE2H3 | cds-NP_014397.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:613253-614413:+ | gene-YNL001W_PE2H4 | rna-NM_001182840.1_PE2H4 | cds-NP_014397.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:627456-628616:+ | gene-YNL001W_S288C | rna-NM_001182840.1_S288C | cds-NP_014397.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000068.1:25160-26320:+ | gene-YNL001W_SA1 | rna-NM_001182840.1_SA1 | cds-NP_014397.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:603732-604892:+ | gene-YNL001W_ThermosaccDry | rna-NM_001182840.1_ThermosaccDry | cds-NP_014397.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:646280-647440:+ | gene-YNL001W_VR1 | rna-NM_001182840.1_VR1 | cds-NP_014397.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:512546-513706:+ | gene-YNL001W_ZTW1 | rna-NM_001182840.1_ZTW1 | cds-NP_014397.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:618774-619933:+ | gene-YNL001W_Sparadoxus | rna-NM_001182840.1_Sparadoxus | cds-NP_014397.1_Sparadoxus | 91.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |