Gene name: DOA4
Reference locus (S288C): YDR069C
Gene biotype: protein_coding
Description: Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication; Belongs to the peptidase C19 family
Top 10 interactors (score): BRO1 (0.998); SNF7 (0.99); VPS20 (0.987); UBI4 (0.979); VPS24 (0.978); DID4 (0.966); VPS27 (0.955); VPS4 (0.955); RSP5 (0.951); UBP6 (0.935); UBP2 (0.93); HSE1 (0.923); DID2 (0.898); RFU1 (0.886); VPS36 (0.875); UBP3 (0.874); PEP4 (0.866); VPS25 (0.862); OTU2 (0.853); STP22 (0.848)
Homologues (species, bitscore): USP8 (Homo sapiens, 206.5); Usp8 (Mus musculus, 208.0); LOC564054 (Danio rerio, 201.8); usp8 (Xenopus tropicalis, 209.5); Usp2 (Drosophila melanogaster, 187.6); E01B7.1 (Caenorhabditis elegans, 157.9); UBP11 (Arabidopsis thaliana, 129.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:562494-565274:- | gene-YDR069C_AKU4011 | rna-NM_001180377.3_AKU4011 | cds-NP_010354.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:560107-562887:+ | gene-YDR069C_BG1 | rna-NM_001180377.3_BG1 | cds-NP_010354.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:594793-597573:- | gene-YDR069C_Bruggeman | rna-NM_001180377.3_Bruggeman | cds-NP_010354.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:578376-581156:- | gene-YDR069C_CAT1 | rna-NM_001180377.3_CAT1 | cds-NP_010354.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:553447-556227:- | gene-YDR069C_CBS1585 | rna-NM_001180377.3_CBS1585 | cds-NP_010354.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:578619-581399:- | gene-YDR069C_CBS436 | rna-NM_001180377.3_CBS436 | cds-NP_010354.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:549859-552639:- | gene-YDR069C_CBS6412 | rna-NM_001180377.3_CBS6412 | cds-NP_010354.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:578525-581305:- | gene-YDR069C_CBS6413 | rna-NM_001180377.3_CBS6413 | cds-NP_010354.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:583927-586707:- | gene-YDR069C_CENPK1137D | rna-NM_001180377.3_CENPK1137D | cds-NP_010354.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:564308-567088:- | gene-YDR069C_EthanolRed | rna-NM_001180377.3_EthanolRed | cds-NP_010354.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:570755-573535:- | gene-YDR069C_FaliES1 | rna-NM_001180377.3_FaliES1 | cds-NP_010354.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:57258-60038:+ | gene-YDR069C_JAY291 | rna-NM_001180377.3_JAY291 | cds-NP_010354.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:579486-582266:- | gene-YDR069C_MUCL30387 | rna-NM_001180377.3_MUCL30387 | cds-NP_010354.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:569876-572656:- | gene-YDR069C_MUCL30388 | rna-NM_001180377.3_MUCL30388 | cds-NP_010354.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:554818-557598:- | gene-YDR069C_MUCL39482 | rna-NM_001180377.3_MUCL39482 | cds-NP_010354.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:485287-488067:- | gene-YDR069C_MUCL42920 | rna-NM_001180377.3_MUCL42920 | cds-NP_010354.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:584862-587642:- | gene-YDR069C_NCIM3186 | rna-NM_001180377.3_NCIM3186 | cds-NP_010354.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:553750-556530:- | gene-YDR069C_NCYC1407 | rna-NM_001180377.3_NCYC1407 | cds-NP_010354.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:573397-576177:- | gene-YDR069C_PE2H3 | rna-NM_001180377.3_PE2H3 | cds-NP_010354.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:572702-575482:- | gene-YDR069C_PE2H4 | rna-NM_001180377.3_PE2H4 | cds-NP_010354.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:584939-587719:- | gene-YDR069C_S288C | rna-NM_001180377.3_S288C | cds-NP_010354.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:57750-60530:+ | gene-YDR069C_SA1 | rna-NM_001180377.3_SA1 | cds-NP_010354.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:570447-573227:- | gene-YDR069C_ThermosaccDry | rna-NM_001180377.3_ThermosaccDry | cds-NP_010354.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:583193-585973:- | gene-YDR069C_VR1 | rna-NM_001180377.3_VR1 | cds-NP_010354.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:568095-570875:- | gene-YDR069C_ZTW1 | rna-NM_001180377.3_ZTW1 | cds-NP_010354.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:572964-575744:- | gene-YDR069C_Sparadoxus | rna-NM_001180377.3_Sparadoxus | cds-NP_010354.3_Sparadoxus | 90.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |