Gene name: DOA1
Reference locus (S288C): YKL213C
Gene biotype: protein_coding
Description: WD repeat protein required for ubiquitin-mediated protein degradation; ubiquitin binding cofactor that complexes with Cdc48p; required for ribophagy; controls cellular ubiquitin concentration; promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
Top 10 interactors (score): CDC48 (0.999); UFD1 (0.996); UFD2 (0.996); UBI4 (0.994); NPL4 (0.989); SHP1 (0.987); VMS1 (0.947); UBX2 (0.93); UBP6 (0.927); OTU1 (0.907); UFD4 (0.9); PRE9 (0.889); HSE1 (0.87); UBX7 (0.868); UBX4 (0.862); DER1 (0.857); CDC73 (0.852); RSP5 (0.842); UBP3 (0.841); UBX5 (0.817)
Homologues (species, bitscore): PLAA (Homo sapiens, 334.7); Plaa (Mus musculus, 338.6); plaa (Danio rerio, 327.0); plaa (Xenopus tropicalis, 327.0); Plap (Drosophila melanogaster, 279.3); ufd-3 (Caenorhabditis elegans, 165.6); AT3G18860 (Arabidopsis thaliana, 276.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:17789-19936:- | gene-YKL213C_AKU4011 | rna-NM_001179778.1_AKU4011 | cds-NP_012709.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000209.1:2804-4951:- | gene-YKL213C_BG1 | rna-NM_001179778.1_BG1 | cds-NP_012709.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:35949-38096:- | gene-YKL213C_Bruggeman | rna-NM_001179778.1_Bruggeman | cds-NP_012709.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:30591-32738:- | gene-YKL213C_CAT1 | rna-NM_001179778.1_CAT1 | cds-NP_012709.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:29807-31954:- | gene-YKL213C_CBS1585 | rna-NM_001179778.1_CBS1585 | cds-NP_012709.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:29493-31640:- | gene-YKL213C_CBS436 | rna-NM_001179778.1_CBS436 | cds-NP_012709.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:15936-18083:- | gene-YKL213C_CBS6412 | rna-NM_001179778.1_CBS6412 | cds-NP_012709.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:30436-32583:- | gene-YKL213C_CBS6413 | rna-NM_001179778.1_CBS6413 | cds-NP_012709.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:31798-33945:- | gene-YKL213C_CENPK1137D | rna-NM_001179778.1_CENPK1137D | cds-NP_012709.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:29921-32068:- | gene-YKL213C_EthanolRed | rna-NM_001179778.1_EthanolRed | cds-NP_012709.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:29791-31938:- | gene-YKL213C_FaliES1 | rna-NM_001179778.1_FaliES1 | cds-NP_012709.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:29425-31572:- | gene-YKL213C_JAY291 | rna-NM_001179778.1_JAY291 | cds-NP_012709.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:38002-40149:- | gene-YKL213C_MUCL30387 | rna-NM_001179778.1_MUCL30387 | cds-NP_012709.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:32329-34476:- | gene-YKL213C_MUCL30388 | rna-NM_001179778.1_MUCL30388 | cds-NP_012709.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:29866-32013:- | gene-YKL213C_MUCL39482 | rna-NM_001179778.1_MUCL39482 | cds-NP_012709.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:33638-35785:- | gene-YKL213C_MUCL42920 | rna-NM_001179778.1_MUCL42920 | cds-NP_012709.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:31949-34096:- | gene-YKL213C_NCIM3186 | rna-NM_001179778.1_NCIM3186 | cds-NP_012709.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:29890-32037:- | gene-YKL213C_NCYC1407 | rna-NM_001179778.1_NCYC1407 | cds-NP_012709.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:38059-40206:- | gene-YKL213C_PE2H3 | rna-NM_001179778.1_PE2H3 | cds-NP_012709.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:34257-36404:- | gene-YKL213C_PE2H4 | rna-NM_001179778.1_PE2H4 | cds-NP_012709.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:31960-34107:- | gene-YKL213C_S288C | rna-NM_001179778.1_S288C | cds-NP_012709.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000092.1:33773-35920:+ | gene-YKL213C_SA1 | rna-NM_001179778.1_SA1 | cds-NP_012709.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:30515-32662:- | gene-YKL213C_ThermosaccDry | rna-NM_001179778.1_ThermosaccDry | cds-NP_012709.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:29674-31821:- | gene-YKL213C_VR1 | rna-NM_001179778.1_VR1 | cds-NP_012709.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:29480-31627:- | gene-YKL213C_ZTW1 | rna-NM_001179778.1_ZTW1 | cds-NP_012709.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:38209-40362:- | gene-YKL213C_Sparadoxus | rna-NM_001179778.1_Sparadoxus | cds-NP_012709.1_Sparadoxus | 88.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |