Gene name: DNL4
Reference locus (S288C): YOR005C
Gene biotype: protein_coding
Description: DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome; Belongs to the ATP-dependent DNA ligase family
Top 10 interactors (score): LIF1 (0.999); YKU70 (0.999); YKU80 (0.999); POL4 (0.997); NEJ1 (0.996); RAD52 (0.995); RAD51 (0.991); PSO2 (0.987); EXO1 (0.973); RAD57 (0.968); TEL1 (0.968); MRE11 (0.967); SGS1 (0.965); RAD27 (0.955); TPP1 (0.954); DNA2 (0.953); RAD54 (0.951); RAD1 (0.94); MEC1 (0.934); RAD59 (0.93)
Homologues (species, bitscore): LIG4 (Homo sapiens, 278.1); Lig4 (Mus musculus, 256.1); lig4 (Danio rerio, 283.5); lig4 (Xenopus tropicalis, 265.4); Lig4 (Drosophila melanogaster, 171.0); lig-4 (Caenorhabditis elegans, 110.2); ATLIG4 (Arabidopsis thaliana, 228.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:318871-321705:- | gene-YOR005C_AKU4011 | rna-NM_001183424.1_AKU4011 | cds-NP_014647.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:134489-137323:- | gene-YOR005C_BG1 | rna-NM_001183424.1_BG1 | cds-NP_014647.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:321642-324476:- | gene-YOR005C_Bruggeman | rna-NM_001183424.1_Bruggeman | cds-NP_014647.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:319797-322631:- | gene-YOR005C_CAT1 | rna-NM_001183424.1_CAT1 | cds-NP_014647.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:313545-316379:- | gene-YOR005C_CBS1585 | rna-NM_001183424.1_CBS1585 | cds-NP_014647.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:317819-320653:- | gene-YOR005C_CBS436 | rna-NM_001183424.1_CBS436 | cds-NP_014647.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:312851-315685:- | gene-YOR005C_CBS6412 | rna-NM_001183424.1_CBS6412 | cds-NP_014647.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:320382-323216:- | gene-YOR005C_CBS6413 | rna-NM_001183424.1_CBS6413 | cds-NP_014647.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:334192-337026:- | gene-YOR005C_CENPK1137D | rna-NM_001183424.1_CENPK1137D | cds-NP_014647.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:315632-318466:- | gene-YOR005C_EthanolRed | rna-NM_001183424.1_EthanolRed | cds-NP_014647.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:318959-321793:- | gene-YOR005C_FaliES1 | rna-NM_001183424.1_FaliES1 | cds-NP_014647.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000015.1:7439-10273:+ | gene-YOR005C_JAY291 | rna-NM_001183424.1_JAY291 | cds-NP_014647.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:325856-328690:- | gene-YOR005C_MUCL30387 | rna-NM_001183424.1_MUCL30387 | cds-NP_014647.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:329292-332126:- | gene-YOR005C_MUCL30388 | rna-NM_001183424.1_MUCL30388 | cds-NP_014647.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:321028-323862:- | gene-YOR005C_MUCL39482 | rna-NM_001183424.1_MUCL39482 | cds-NP_014647.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:335882-338716:- | gene-YOR005C_MUCL42920 | rna-NM_001183424.1_MUCL42920 | cds-NP_014647.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:334398-337232:- | gene-YOR005C_NCIM3186 | rna-NM_001183424.1_NCIM3186 | cds-NP_014647.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:327713-330547:- | gene-YOR005C_NCYC1407 | rna-NM_001183424.1_NCYC1407 | cds-NP_014647.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:322413-325247:- | gene-YOR005C_PE2H3 | rna-NM_001183424.1_PE2H3 | cds-NP_014647.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:332792-335626:- | gene-YOR005C_PE2H4 | rna-NM_001183424.1_PE2H4 | cds-NP_014647.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:334509-337343:- | gene-YOR005C_S288C | rna-NM_001183424.1_S288C | cds-NP_014647.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:302480-305314:- | gene-YOR005C_SA1 | rna-NM_001183424.1_SA1 | cds-NP_014647.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:317530-320364:- | gene-YOR005C_ThermosaccDry | rna-NM_001183424.1_ThermosaccDry | cds-NP_014647.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:318364-321198:- | gene-YOR005C_VR1 | rna-NM_001183424.1_VR1 | cds-NP_014647.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:52194-55028:- | gene-YOR005C_ZTW1 | rna-NM_001183424.1_ZTW1 | cds-NP_014647.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:326069-328903:- | gene-YOR005C_Sparadoxus | rna-NM_001183424.1_Sparadoxus | cds-NP_014647.1_Sparadoxus | 88.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |