Gene name: DNF3
Reference locus (S288C): YMR162C
Gene biotype: protein_coding
Description: Probable phospholipid-transporting ATPase DNF3; Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily
Top 10 interactors (score): CDC50 (0.994); YNR048W (0.979); LEM3 (0.964); FPK1 (0.91); VPS8 (0.896); JJJ1 (0.896); RSM26 (0.896); MSY1 (0.896); RBA50 (0.894); KIN82 (0.785); RCY1 (0.748); ANY1 (0.715); SNC1 (0.713); GEA2 (0.678); SPT5 (0.651); PCA1 (0.636); CHO1 (0.623); DNF1 (0.598); PIK1 (0.58); KES1 (0.568)
Homologues (species, bitscore): ATP8A1 (Homo sapiens, 550.4); Atp8a1 (Mus musculus, 553.5); atp8a2 (Danio rerio, 542.7); atp11b (Xenopus tropicalis, 476.9); CG42321 (Drosophila melanogaster, 537.7); tat-2 (Caenorhabditis elegans, 499.6); ALA3 (Arabidopsis thaliana, 555.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:618456-623426:- | gene-YMR162C_AKU4011 | rna-NM_001182666.1_AKU4011 | cds-NP_013885.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000068.1:49123-54093:+ | gene-YMR162C_BG1 | rna-NM_001182666.1_BG1 | cds-NP_013885.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:561631-566601:- | gene-YMR162C_Bruggeman | rna-NM_001182666.1_Bruggeman | cds-NP_013885.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:563838-568808:- | gene-YMR162C_CAT1 | rna-NM_001182666.1_CAT1 | cds-NP_013885.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:551381-556351:- | gene-YMR162C_CBS1585 | rna-NM_001182666.1_CBS1585 | cds-NP_013885.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:555249-560219:- | gene-YMR162C_CBS436 | rna-NM_001182666.1_CBS436 | cds-NP_013885.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:663998-668968:- | gene-YMR162C_CBS6412 | rna-NM_001182666.1_CBS6412 | cds-NP_013885.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:549931-554901:- | gene-YMR162C_CBS6413 | rna-NM_001182666.1_CBS6413 | cds-NP_013885.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:573454-578424:- | gene-YMR162C_CENPK1137D | rna-NM_001182666.1_CENPK1137D | cds-NP_013885.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:549546-554516:- | gene-YMR162C_EthanolRed | rna-NM_001182666.1_EthanolRed | cds-NP_013885.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:556545-561515:- | gene-YMR162C_FaliES1 | rna-NM_001182666.1_FaliES1 | cds-NP_013885.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000292.1:16018-20988:+ | gene-YMR162C_JAY291 | rna-NM_001182666.1_JAY291 | cds-NP_013885.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:556341-561311:- | gene-YMR162C_MUCL30387 | rna-NM_001182666.1_MUCL30387 | cds-NP_013885.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:561865-566835:- | gene-YMR162C_MUCL30388 | rna-NM_001182666.1_MUCL30388 | cds-NP_013885.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:552067-557037:- | gene-YMR162C_MUCL39482 | rna-NM_001182666.1_MUCL39482 | cds-NP_013885.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:558937-563907:- | gene-YMR162C_MUCL42920 | rna-NM_001182666.1_MUCL42920 | cds-NP_013885.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:578905-583875:- | gene-YMR162C_NCIM3186 | rna-NM_001182666.1_NCIM3186 | cds-NP_013885.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:551769-556739:- | gene-YMR162C_NCYC1407 | rna-NM_001182666.1_NCYC1407 | cds-NP_013885.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:562147-567117:- | gene-YMR162C_PE2H3 | rna-NM_001182666.1_PE2H3 | cds-NP_013885.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:562597-567567:- | gene-YMR162C_PE2H4 | rna-NM_001182666.1_PE2H4 | cds-NP_013885.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:578951-583921:- | gene-YMR162C_S288C | rna-NM_001182666.1_S288C | cds-NP_013885.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:222514-227484:+ | gene-YMR162C_SA1 | rna-NM_001182666.1_SA1 | cds-NP_013885.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:552193-557163:- | gene-YMR162C_ThermosaccDry | rna-NM_001182666.1_ThermosaccDry | cds-NP_013885.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:564654-569624:- | gene-YMR162C_VR1 | rna-NM_001182666.1_VR1 | cds-NP_013885.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:527086-532056:- | gene-YMR162C_ZTW1 | rna-NM_001182666.1_ZTW1 | cds-NP_013885.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:564707-569677:- | gene-YMR162C_Sparadoxus | rna-NM_001182666.1_Sparadoxus | cds-NP_013885.1_Sparadoxus | 90.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |