Gene name: DNF2
Reference locus (S288C): YDR093W
Gene biotype: protein_coding
Description: Phospholipid-transporting ATPase DNF2; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication
Top 10 interactors (score): DNF1 (0.999); LEM3 (0.999); CDC50 (0.973); FPK1 (0.96); KIN82 (0.913); YNR048W (0.895); ANY1 (0.759); NEO1 (0.723); GIN4 (0.712); CHO1 (0.7); YOR1 (0.674); RCY1 (0.666); CDC42 (0.609); RDI1 (0.602); ORM1 (0.6); AKL1 (0.595); RSB1 (0.593); DRS2 (0.588); ALE1 (0.583); CDC28 (0.564)
Homologues (species, bitscore): ATP8B1 (Homo sapiens, 690.3); Atp8b1 (Mus musculus, 681.0); atp8b1 (Danio rerio, 687.2); atp8b2 (Xenopus tropicalis, 683.7); CG42321 (Drosophila melanogaster, 632.5); tat-2 (Caenorhabditis elegans, 662.1); AT3G27870 (Arabidopsis thaliana, 684.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:608838-613676:+ | gene-YDR093W_AKU4011 | rna-NM_001180401.1_AKU4011 | cds-NP_010378.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:511601-516439:- | gene-YDR093W_BG1 | rna-NM_001180401.1_BG1 | cds-NP_010378.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:640925-645763:+ | gene-YDR093W_Bruggeman | rna-NM_001180401.1_Bruggeman | cds-NP_010378.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:625756-630594:+ | gene-YDR093W_CAT1 | rna-NM_001180401.1_CAT1 | cds-NP_010378.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:599858-604696:+ | gene-YDR093W_CBS1585 | rna-NM_001180401.1_CBS1585 | cds-NP_010378.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:624735-629573:+ | gene-YDR093W_CBS436 | rna-NM_001180401.1_CBS436 | cds-NP_010378.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:596272-601110:+ | gene-YDR093W_CBS6412 | rna-NM_001180401.1_CBS6412 | cds-NP_010378.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:624803-629641:+ | gene-YDR093W_CBS6413 | rna-NM_001180401.1_CBS6413 | cds-NP_010378.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:630253-635128:+ | gene-YDR093W_CENPK1137D | rna-NM_001180401.1_CENPK1137D | cds-NP_010378.1_CENPK1137D | 98.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:610628-615466:+ | gene-YDR093W_EthanolRed | rna-NM_001180401.1_EthanolRed | cds-NP_010378.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:617421-622259:+ | gene-YDR093W_FaliES1 | rna-NM_001180401.1_FaliES1 | cds-NP_010378.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:9145-13983:- | gene-YDR093W_JAY291 | rna-NM_001180401.1_JAY291 | cds-NP_010378.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:625544-630382:+ | gene-YDR093W_MUCL30387 | rna-NM_001180401.1_MUCL30387 | cds-NP_010378.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:615853-620691:+ | gene-YDR093W_MUCL30388 | rna-NM_001180401.1_MUCL30388 | cds-NP_010378.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:601228-606066:+ | gene-YDR093W_MUCL39482 | rna-NM_001180401.1_MUCL39482 | cds-NP_010378.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:532545-537740:+ | gene-YDR093W_MUCL42920 | rna-NM_001180401.1_MUCL42920 | cds-NP_010378.1_MUCL42920 | 92.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:631205-636043:+ | gene-YDR093W_NCIM3186 | rna-NM_001180401.1_NCIM3186 | cds-NP_010378.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:600137-604975:+ | gene-YDR093W_NCYC1407 | rna-NM_001180401.1_NCYC1407 | cds-NP_010378.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:619602-624440:+ | gene-YDR093W_PE2H3 | rna-NM_001180401.1_PE2H3 | cds-NP_010378.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:618907-623745:+ | gene-YDR093W_PE2H4 | rna-NM_001180401.1_PE2H4 | cds-NP_010378.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:631282-636120:+ | gene-YDR093W_S288C | rna-NM_001180401.1_S288C | cds-NP_010378.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:9219-14057:- | gene-YDR093W_SA1 | rna-NM_001180401.1_SA1 | cds-NP_010378.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:616951-621789:+ | gene-YDR093W_ThermosaccDry | rna-NM_001180401.1_ThermosaccDry | cds-NP_010378.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:629501-634339:+ | gene-YDR093W_VR1 | rna-NM_001180401.1_VR1 | cds-NP_010378.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:614532-619370:+ | gene-YDR093W_ZTW1 | rna-NM_001180401.1_ZTW1 | cds-NP_010378.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:619128-623966:+ | gene-YDR093W_Sparadoxus | rna-NM_001180401.1_Sparadoxus | cds-NP_010378.1_Sparadoxus | 90.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |