Gene name: DNF1
Reference locus (S288C): YER166W
Gene biotype: protein_coding
Description: Phospholipid-transporting ATPase DNF1; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication
Top 10 interactors (score): LEM3 (0.999); DNF2 (0.999); CDC50 (0.998); DRS2 (0.98); FPK1 (0.978); SEC7 (0.94); KIN82 (0.913); YNR048W (0.89); CHO1 (0.795); RCY1 (0.772); ANY1 (0.755); GIN4 (0.744); ORM1 (0.716); SNC1 (0.711); NEO1 (0.71); SLA1 (0.696); YPK1 (0.688); YOR1 (0.663); PAN1 (0.639); YOR072W (0.614)
Homologues (species, bitscore): ATP8B4 (Homo sapiens, 687.2); Atp8b1 (Mus musculus, 673.7); atp8b5b (Danio rerio, 686.0); atp8b2 (Xenopus tropicalis, 681.0); CG42321 (Drosophila melanogaster, 638.6); tat-2 (Caenorhabditis elegans, 681.4); ALA3 (Arabidopsis thaliana, 729.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:494299-499014:+ | gene-YER166W_AKU4011 | rna-NM_001179056.3_AKU4011 | cds-NP_011093.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:34361-39076:- | gene-YER166W_BG1 | rna-NM_001179056.3_BG1 | cds-NP_011093.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:507011-511726:+ | gene-YER166W_Bruggeman | rna-NM_001179056.3_Bruggeman | cds-NP_011093.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:493604-498319:+ | gene-YER166W_CAT1 | rna-NM_001179056.3_CAT1 | cds-NP_011093.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:494106-498821:+ | gene-YER166W_CBS1585 | rna-NM_001179056.3_CBS1585 | cds-NP_011093.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:503989-508704:+ | gene-YER166W_CBS436 | rna-NM_001179056.3_CBS436 | cds-NP_011093.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:492083-496798:+ | gene-YER166W_CBS6412 | rna-NM_001179056.3_CBS6412 | cds-NP_011093.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:500652-505367:+ | gene-YER166W_CBS6413 | rna-NM_001179056.3_CBS6413 | cds-NP_011093.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:510515-515230:+ | gene-YER166W_CENPK1137D | rna-NM_001179056.3_CENPK1137D | cds-NP_011093.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:500245-504960:+ | gene-YER166W_EthanolRed | rna-NM_001179056.3_EthanolRed | cds-NP_011093.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:501181-505896:+ | gene-YER166W_FaliES1 | rna-NM_001179056.3_FaliES1 | cds-NP_011093.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000169.1:34011-38726:- | gene-YER166W_JAY291 | rna-NM_001179056.3_JAY291 | cds-NP_011093.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:494335-499050:+ | gene-YER166W_MUCL30387 | rna-NM_001179056.3_MUCL30387 | cds-NP_011093.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:497259-501974:+ | gene-YER166W_MUCL30388 | rna-NM_001179056.3_MUCL30388 | cds-NP_011093.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:490064-494779:+ | gene-YER166W_MUCL39482 | rna-NM_001179056.3_MUCL39482 | cds-NP_011093.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:504575-509290:+ | gene-YER166W_MUCL42920 | rna-NM_001179056.3_MUCL42920 | cds-NP_011093.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:512743-517458:+ | gene-YER166W_NCIM3186 | rna-NM_001179056.3_NCIM3186 | cds-NP_011093.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:499520-504235:+ | gene-YER166W_NCYC1407 | rna-NM_001179056.3_NCYC1407 | cds-NP_011093.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:515423-520138:+ | gene-YER166W_PE2H3 | rna-NM_001179056.3_PE2H3 | cds-NP_011093.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:505364-510079:+ | gene-YER166W_PE2H4 | rna-NM_001179056.3_PE2H4 | cds-NP_011093.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:512744-517459:+ | gene-YER166W_S288C | rna-NM_001179056.3_S288C | cds-NP_011093.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:64909-69624:+ | gene-YER166W_SA1 | rna-NM_001179056.3_SA1 | cds-NP_011093.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:501981-506696:+ | gene-YER166W_ThermosaccDry | rna-NM_001179056.3_ThermosaccDry | cds-NP_011093.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:495269-499984:+ | gene-YER166W_VR1 | rna-NM_001179056.3_VR1 | cds-NP_011093.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000011.1:14832-19547:+ | gene-YER166W_ZTW1 | rna-NM_001179056.3_ZTW1 | cds-NP_011093.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:503214-507929:+ | gene-YER166W_Sparadoxus | rna-NM_001179056.3_Sparadoxus | cds-NP_011093.3_Sparadoxus | 91.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |