Gene name: DNA2
Reference locus (S288C): YHR164C
Gene biotype: protein_coding
Description: Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; component of telomeric chromatin with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress; human homolog DNA2 complements yeast dna2 mutant
Top 10 interactors (score): RFA1 (0.999); EXO1 (0.999); SGS1 (0.999); RAD27 (0.999); CTF4 (0.999); PIF1 (0.998); TOP3 (0.997); RMI1 (0.996); RAD52 (0.994); MET18 (0.994); MEC1 (0.994); RAD51 (0.992); TEL1 (0.989); CDC9 (0.989); MUS81 (0.988); YKU70 (0.986); POL3 (0.983); RAD9 (0.982); SPO11 (0.981); MRE11 (0.98)
Homologues (species, bitscore): DNA2 (Homo sapiens, 446.8); Dna2 (Mus musculus, 484.2); dna2 (Danio rerio, 438.0); dna2 (Xenopus tropicalis, 300.8); CG2990 (Drosophila melanogaster, 305.4); dna-2 (Caenorhabditis elegans, 328.6); emb2411 (Arabidopsis thaliana, 476.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:411703-416271:- | gene-YHR164C_AKU4011 | rna-NM_001179295.1_AKU4011 | cds-NP_012034.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:101467-106035:+ | gene-YHR164C_BG1 | rna-NM_001179295.1_BG1 | cds-NP_012034.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:418944-423512:- | gene-YHR164C_Bruggeman | rna-NM_001179295.1_Bruggeman | cds-NP_012034.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:414349-418917:- | gene-YHR164C_CAT1 | rna-NM_001179295.1_CAT1 | cds-NP_012034.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:411160-415728:- | gene-YHR164C_CBS1585 | rna-NM_001179295.1_CBS1585 | cds-NP_012034.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:408602-413170:- | gene-YHR164C_CBS436 | rna-NM_001179295.1_CBS436 | cds-NP_012034.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:411613-416181:- | gene-YHR164C_CBS6412 | rna-NM_001179295.1_CBS6412 | cds-NP_012034.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:412040-416608:- | gene-YHR164C_CBS6413 | rna-NM_001179295.1_CBS6413 | cds-NP_012034.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:417782-422350:- | gene-YHR164C_CENPK1137D | rna-NM_001179295.1_CENPK1137D | cds-NP_012034.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:470254-474822:- | gene-YHR164C_EthanolRed | rna-NM_001179295.1_EthanolRed | cds-NP_012034.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:412697-417265:- | gene-YHR164C_FaliES1 | rna-NM_001179295.1_FaliES1 | cds-NP_012034.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000017.1:22577-27145:+ | gene-YHR164C_JAY291 | rna-NM_001179295.1_JAY291 | cds-NP_012034.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:420015-424583:- | gene-YHR164C_MUCL30387 | rna-NM_001179295.1_MUCL30387 | cds-NP_012034.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:419454-424022:- | gene-YHR164C_MUCL30388 | rna-NM_001179295.1_MUCL30388 | cds-NP_012034.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:411071-415639:- | gene-YHR164C_MUCL39482 | rna-NM_001179295.1_MUCL39482 | cds-NP_012034.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:417677-422245:- | gene-YHR164C_MUCL42920 | rna-NM_001179295.1_MUCL42920 | cds-NP_012034.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:424492-429060:- | gene-YHR164C_NCIM3186 | rna-NM_001179295.1_NCIM3186 | cds-NP_012034.1_NCIM3186 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:413529-418097:- | gene-YHR164C_NCYC1407 | rna-NM_001179295.1_NCYC1407 | cds-NP_012034.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:412671-417239:- | gene-YHR164C_PE2H3 | rna-NM_001179295.1_PE2H3 | cds-NP_012034.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:420098-424666:- | gene-YHR164C_PE2H4 | rna-NM_001179295.1_PE2H4 | cds-NP_012034.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:424610-429178:- | gene-YHR164C_S288C | rna-NM_001179295.1_S288C | cds-NP_012034.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000070.1:22638-27206:+ | gene-YHR164C_SA1 | rna-NM_001179295.1_SA1 | cds-NP_012034.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:413780-418348:- | gene-YHR164C_ThermosaccDry | rna-NM_001179295.1_ThermosaccDry | cds-NP_012034.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:421597-426165:- | gene-YHR164C_VR1 | rna-NM_001179295.1_VR1 | cds-NP_012034.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:404020-408588:- | gene-YHR164C_ZTW1 | rna-NM_001179295.1_ZTW1 | cds-NP_012034.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:410145-414713:- | gene-YHR164C_Sparadoxus | rna-NM_001179295.1_Sparadoxus | cds-NP_012034.1_Sparadoxus | 88.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |