Gene name: DMA1
Reference locus (S288C): YHR115C
Gene biotype: protein_coding
Description: Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication
Top 10 interactors (score): BUB2 (0.932); CDC123 (0.92); UBC13 (0.917); TEL1 (0.906); DMA2 (0.893); CDC5 (0.868); MRE11 (0.806); UFD4 (0.802); RAD50 (0.801); KIN4 (0.798); SWE1 (0.793); HTA2 (0.792); HTA1 (0.782); RAD9 (0.781); VAC17 (0.776); YDR365W-A (0.749); RTT107 (0.742); UBC4 (0.738); TEM1 (0.737); FAR8 (0.729)
Homologues (species, bitscore): SLMAP (Homo sapiens, 60.1); Slmap (Mus musculus, 57.0); slmapa (Danio rerio, 59.7); slmap (Xenopus tropicalis, 59.7); Slmap (Drosophila melanogaster, 53.5); M4.1 (Caenorhabditis elegans, 58.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:327035-328285:- | gene-YHR115C_AKU4011 | rna-NM_001179245.1_AKU4011 | cds-NP_011983.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:189589-190839:+ | gene-YHR115C_BG1 | rna-NM_001179245.1_BG1 | cds-NP_011983.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:334325-335575:- | gene-YHR115C_Bruggeman | rna-NM_001179245.1_Bruggeman | cds-NP_011983.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:329463-330713:- | gene-YHR115C_CAT1 | rna-NM_001179245.1_CAT1 | cds-NP_011983.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:326059-327309:- | gene-YHR115C_CBS1585 | rna-NM_001179245.1_CBS1585 | cds-NP_011983.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:323417-324667:- | gene-YHR115C_CBS436 | rna-NM_001179245.1_CBS436 | cds-NP_011983.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:327546-328747:- | gene-YHR115C_CBS6412 | rna-NM_001179245.1_CBS6412 | cds-NP_011983.1_CBS6412 | 79.5 | 89.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:327086-328336:- | gene-YHR115C_CBS6413 | rna-NM_001179245.1_CBS6413 | cds-NP_011983.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:333283-334533:- | gene-YHR115C_CENPK1137D | rna-NM_001179245.1_CENPK1137D | cds-NP_011983.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:385940-387190:- | gene-YHR115C_EthanolRed | rna-NM_001179245.1_EthanolRed | cds-NP_011983.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:327428-328678:- | gene-YHR115C_FaliES1 | rna-NM_001179245.1_FaliES1 | cds-NP_011983.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000139.1:44-1294:- | gene-YHR115C_JAY291 | rna-NM_001179245.1_JAY291 | cds-NP_011983.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:334053-335303:- | gene-YHR115C_MUCL30387 | rna-NM_001179245.1_MUCL30387 | cds-NP_011983.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:333703-334950:- | gene-YHR115C_MUCL30388 | rna-NM_001179245.1_MUCL30388 | cds-NP_011983.1_MUCL30388 | 99.4 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:326398-327648:- | gene-YHR115C_MUCL39482 | rna-NM_001179245.1_MUCL39482 | cds-NP_011983.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:332641-333888:- | gene-YHR115C_MUCL42920 | rna-NM_001179245.1_MUCL42920 | cds-NP_011983.1_MUCL42920 | 99.5 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:339991-341241:- | gene-YHR115C_NCIM3186 | rna-NM_001179245.1_NCIM3186 | cds-NP_011983.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:328608-329858:- | gene-YHR115C_NCYC1407 | rna-NM_001179245.1_NCYC1407 | cds-NP_011983.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:328060-329310:- | gene-YHR115C_PE2H3 | rna-NM_001179245.1_PE2H3 | cds-NP_011983.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:335487-336737:- | gene-YHR115C_PE2H4 | rna-NM_001179245.1_PE2H4 | cds-NP_011983.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:340109-341359:- | gene-YHR115C_S288C | rna-NM_001179245.1_S288C | cds-NP_011983.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:17613-18863:+ | gene-YHR115C_SA1 | rna-NM_001179245.1_SA1 | cds-NP_011983.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:328511-329761:- | gene-YHR115C_ThermosaccDry | rna-NM_001179245.1_ThermosaccDry | cds-NP_011983.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:336132-337382:- | gene-YHR115C_VR1 | rna-NM_001179245.1_VR1 | cds-NP_011983.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:319522-320772:- | gene-YHR115C_ZTW1 | rna-NM_001179245.1_ZTW1 | cds-NP_011983.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:325200-326459:- | gene-YHR115C_Sparadoxus | rna-NM_001179245.1_Sparadoxus | cds-NP_011983.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |