Gene name: DLD3
Reference locus (S288C): YEL071W
Gene biotype: protein_coding
Description: D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
Top 10 interactors (score): CYB2 (0.98); CIT2 (0.967); PYC1 (0.956); PDB1 (0.936); PYC2 (0.926); GLO4 (0.91); GLO2 (0.908); SNO4 (0.904); HSP33 (0.904); MAE1 (0.903); PDA1 (0.901); HSP31 (0.9); HSP32 (0.9); DLD1 (0.848); ILV2 (0.822); FAR8 (0.819); EMW1 (0.819); VMA8 (0.819); ILV6 (0.814); DLD2 (0.806)
Homologues (species, bitscore): D2HGDH (Homo sapiens, 446.8); D2hgdh (Mus musculus, 452.2); d2hgdh (Danio rerio, 433.0); D2HGDH (Xenopus tropicalis, 454.5); CG3835 (Drosophila melanogaster, 419.1); F54D5.12 (Caenorhabditis elegans, 378.3); D2HGDH (Arabidopsis thaliana, 458.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:10761-12251:+ | gene-YEL071W_AKU4011 | rna-NM_001178886.1_AKU4011 | cds-NP_010843.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000092.1:1759-3249:- | gene-YEL071W_BG1 | rna-NM_001178886.1_BG1 | cds-NP_010843.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:14277-15767:+ | gene-YEL071W_Bruggeman | rna-NM_001178886.1_Bruggeman | cds-NP_010843.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:12727-14217:+ | gene-YEL071W_CAT1 | rna-NM_001178886.1_CAT1 | cds-NP_010843.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:10754-12244:+ | gene-YEL071W_CBS1585 | rna-NM_001178886.1_CBS1585 | cds-NP_010843.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:11765-13255:+ | gene-YEL071W_CBS436 | rna-NM_001178886.1_CBS436 | cds-NP_010843.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:10711-12201:+ | gene-YEL071W_CBS6412 | rna-NM_001178886.1_CBS6412 | cds-NP_010843.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:15101-16591:+ | gene-YEL071W_CBS6413 | rna-NM_001178886.1_CBS6413 | cds-NP_010843.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:14204-15694:+ | gene-YEL071W_CENPK1137D | rna-NM_001178886.1_CENPK1137D | cds-NP_010843.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:10283-11773:+ | gene-YEL071W_EthanolRed | rna-NM_001178886.1_EthanolRed | cds-NP_010843.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:10297-11787:+ | gene-YEL071W_FaliES1 | rna-NM_001178886.1_FaliES1 | cds-NP_010843.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000108.1:1735-3225:- | gene-YEL071W_JAY291 | rna-NM_001178886.1_JAY291 | cds-NP_010843.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:14463-15953:+ | gene-YEL071W_MUCL30387 | rna-NM_001178886.1_MUCL30387 | cds-NP_010843.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:10834-12324:+ | gene-YEL071W_MUCL30388 | rna-NM_001178886.1_MUCL30388 | cds-NP_010843.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:9827-11317:+ | gene-YEL071W_MUCL39482 | rna-NM_001178886.1_MUCL39482 | cds-NP_010843.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:14464-15954:+ | gene-YEL071W_MUCL42920 | rna-NM_001178886.1_MUCL42920 | cds-NP_010843.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:16354-17844:+ | gene-YEL071W_NCIM3186 | rna-NM_001178886.1_NCIM3186 | cds-NP_010843.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:14924-16414:+ | gene-YEL071W_NCYC1407 | rna-NM_001178886.1_NCYC1407 | cds-NP_010843.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:19171-20661:+ | gene-YEL071W_PE2H3 | rna-NM_001178886.1_PE2H3 | cds-NP_010843.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:15108-16598:+ | gene-YEL071W_PE2H4 | rna-NM_001178886.1_PE2H4 | cds-NP_010843.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:16355-17845:+ | gene-YEL071W_S288C | rna-NM_001178886.1_S288C | cds-NP_010843.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:69051-70541:- | gene-YEL071W_SA1 | rna-NM_001178886.1_SA1 | cds-NP_010843.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:10362-11852:+ | gene-YEL071W_ThermosaccDry | rna-NM_001178886.1_ThermosaccDry | cds-NP_010843.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:10404-11894:+ | gene-YEL071W_VR1 | rna-NM_001178886.1_VR1 | cds-NP_010843.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:10119-11609:+ | gene-YEL071W_ZTW1 | rna-NM_001178886.1_ZTW1 | cds-NP_010843.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:8721-10211:+ | gene-YEL071W_Sparadoxus | rna-NM_001178886.1_Sparadoxus | cds-NP_010843.1_Sparadoxus | 92.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |