Gene name: DLD2
Reference locus (S288C): YDL178W
Gene biotype: protein_coding
Description: D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix; Belongs to the FAD-binding oxidoreductase/transferase type 4 family
Top 10 interactors (score): CYB2 (0.983); VMA8 (0.968); EMW1 (0.962); PYC1 (0.951); PYC2 (0.951); PDB1 (0.918); GLO4 (0.911); GLO2 (0.908); MAE1 (0.903); PDA1 (0.902); ILV6 (0.901); HSP32 (0.9); SNO4 (0.9); HSP33 (0.9); HSP31 (0.9); CIR2 (0.887); DLD1 (0.871); SDS22 (0.836); ACT1 (0.835); ILV2 (0.822)
Homologues (species, bitscore): D2HGDH (Homo sapiens, 511.1); D2hgdh (Mus musculus, 506.1); d2hgdh (Danio rerio, 503.1); D2HGDH (Xenopus tropicalis, 528.9); CG3835 (Drosophila melanogaster, 467.2); F54D5.12 (Caenorhabditis elegans, 426.8); D2HGDH (Arabidopsis thaliana, 516.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:123948-125540:+ | gene-YDL178W_AKU4011 | rna-NM_001180238.1_AKU4011 | cds-NP_010103.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:424169-425761:- | gene-YDL178W_BG1 | rna-NM_001180238.1_BG1 | cds-NP_010103.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:140002-141594:+ | gene-YDL178W_Bruggeman | rna-NM_001180238.1_Bruggeman | cds-NP_010103.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:138329-139921:+ | gene-YDL178W_CAT1 | rna-NM_001180238.1_CAT1 | cds-NP_010103.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:121986-123578:+ | gene-YDL178W_CBS1585 | rna-NM_001180238.1_CBS1585 | cds-NP_010103.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:138947-140539:+ | gene-YDL178W_CBS436 | rna-NM_001180238.1_CBS436 | cds-NP_010103.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:121549-123141:+ | gene-YDL178W_CBS6412 | rna-NM_001180238.1_CBS6412 | cds-NP_010103.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:140360-141952:+ | gene-YDL178W_CBS6413 | rna-NM_001180238.1_CBS6413 | cds-NP_010103.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:138195-139787:+ | gene-YDL178W_CENPK1137D | rna-NM_001180238.1_CENPK1137D | cds-NP_010103.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:135368-136960:+ | gene-YDL178W_EthanolRed | rna-NM_001180238.1_EthanolRed | cds-NP_010103.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:140694-142286:+ | gene-YDL178W_FaliES1 | rna-NM_001180238.1_FaliES1 | cds-NP_010103.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000032.1:77223-78815:- | gene-YDL178W_JAY291 | rna-NM_001180238.1_JAY291 | cds-NP_010103.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:138308-139900:+ | gene-YDL178W_MUCL30387 | rna-NM_001180238.1_MUCL30387 | cds-NP_010103.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:129953-131545:+ | gene-YDL178W_MUCL30388 | rna-NM_001180238.1_MUCL30388 | cds-NP_010103.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:123128-124720:+ | gene-YDL178W_MUCL39482 | rna-NM_001180238.1_MUCL39482 | cds-NP_010103.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | MBVV01000307.1:44649-46241:- | gene-YDL178W_MUCL42920 | rna-NM_001180238.1_MUCL42920 | cds-NP_010103.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:139445-141037:+ | gene-YDL178W_NCIM3186 | rna-NM_001180238.1_NCIM3186 | cds-NP_010103.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:123017-124609:+ | gene-YDL178W_NCYC1407 | rna-NM_001180238.1_NCYC1407 | cds-NP_010103.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:130328-131920:+ | gene-YDL178W_PE2H3 | rna-NM_001180238.1_PE2H3 | cds-NP_010103.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:130332-131924:+ | gene-YDL178W_PE2H4 | rna-NM_001180238.1_PE2H4 | cds-NP_010103.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:139522-141114:+ | gene-YDL178W_S288C | rna-NM_001180238.1_S288C | cds-NP_010103.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000043.1:5105-6697:+ | gene-YDL178W_SA1 | rna-NM_001180238.1_SA1 | cds-NP_010103.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:140454-142046:+ | gene-YDL178W_ThermosaccDry | rna-NM_001180238.1_ThermosaccDry | cds-NP_010103.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:141099-142691:+ | gene-YDL178W_VR1 | rna-NM_001180238.1_VR1 | cds-NP_010103.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:138627-140219:+ | gene-YDL178W_ZTW1 | rna-NM_001180238.1_ZTW1 | cds-NP_010103.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:140858-142450:+ | gene-YDL178W_Sparadoxus | rna-NM_001180238.1_Sparadoxus | cds-NP_010103.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |