Gene name: DIS3
Reference locus (S288C): YOL021C
Gene biotype: protein_coding
Description: Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress
Top 10 interactors (score): SKI7 (0.999); SKI6 (0.999); RRP45 (0.999); MTR4 (0.999); RRP42 (0.999); RRP4 (0.999); CSL4 (0.999); RRP40 (0.999); LRP1 (0.999); RRP43 (0.999); RRP6 (0.999); MTR3 (0.999); MPP6 (0.999); RRP46 (0.999); RAT1 (0.99); XRN1 (0.989); UTP13 (0.989); SKI2 (0.985); SUV3 (0.982); SAS10 (0.959)
Homologues (species, bitscore): DIS3 (Homo sapiens, 757.7); Dis3 (Mus musculus, 763.1); dis3 (Danio rerio, 770.8); dis3 (Xenopus tropicalis, 755.0); Dis3 (Drosophila melanogaster, 750.7); dis-3 (Caenorhabditis elegans, 652.1); EMB2763 (Arabidopsis thaliana, 677.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:266811-269816:- | gene-YOL021C_AKU4011 | rna-NM_001183275.1_AKU4011 | cds-NP_014621.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:82397-85402:- | gene-YOL021C_BG1 | rna-NM_001183275.1_BG1 | cds-NP_014621.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:269636-272641:- | gene-YOL021C_Bruggeman | rna-NM_001183275.1_Bruggeman | cds-NP_014621.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:267511-270516:- | gene-YOL021C_CAT1 | rna-NM_001183275.1_CAT1 | cds-NP_014621.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:261489-264494:- | gene-YOL021C_CBS1585 | rna-NM_001183275.1_CBS1585 | cds-NP_014621.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:265727-268732:- | gene-YOL021C_CBS436 | rna-NM_001183275.1_CBS436 | cds-NP_014621.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:260845-263850:- | gene-YOL021C_CBS6412 | rna-NM_001183275.1_CBS6412 | cds-NP_014621.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:268372-271377:- | gene-YOL021C_CBS6413 | rna-NM_001183275.1_CBS6413 | cds-NP_014621.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:282122-285127:- | gene-YOL021C_CENPK1137D | rna-NM_001183275.1_CENPK1137D | cds-NP_014621.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:263638-266643:- | gene-YOL021C_EthanolRed | rna-NM_001183275.1_EthanolRed | cds-NP_014621.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:266965-269970:- | gene-YOL021C_FaliES1 | rna-NM_001183275.1_FaliES1 | cds-NP_014621.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000351.1:2834-5839:+ | gene-YOL021C_JAY291 | rna-NM_001183275.1_JAY291 | cds-NP_014621.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:273569-276574:- | gene-YOL021C_MUCL30387 | rna-NM_001183275.1_MUCL30387 | cds-NP_014621.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:277010-280015:- | gene-YOL021C_MUCL30388 | rna-NM_001183275.1_MUCL30388 | cds-NP_014621.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:268974-271979:- | gene-YOL021C_MUCL39482 | rna-NM_001183275.1_MUCL39482 | cds-NP_014621.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:283894-286899:- | gene-YOL021C_MUCL42920 | rna-NM_001183275.1_MUCL42920 | cds-NP_014621.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:282310-285315:- | gene-YOL021C_NCIM3186 | rna-NM_001183275.1_NCIM3186 | cds-NP_014621.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:275706-278711:- | gene-YOL021C_NCYC1407 | rna-NM_001183275.1_NCYC1407 | cds-NP_014621.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:258091-261096:- | gene-YOL021C_PE2H3 | rna-NM_001183275.1_PE2H3 | cds-NP_014621.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:269065-272070:- | gene-YOL021C_PE2H4 | rna-NM_001183275.1_PE2H4 | cds-NP_014621.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:282421-285426:- | gene-YOL021C_S288C | rna-NM_001183275.1_S288C | cds-NP_014621.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:250417-253422:- | gene-YOL021C_SA1 | rna-NM_001183275.1_SA1 | cds-NP_014621.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:265536-268541:- | gene-YOL021C_ThermosaccDry | rna-NM_001183275.1_ThermosaccDry | cds-NP_014621.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:265571-268576:- | gene-YOL021C_VR1 | rna-NM_001183275.1_VR1 | cds-NP_014621.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:187-3192:- | gene-YOL021C_ZTW1 | rna-NM_001183275.1_ZTW1 | cds-NP_014621.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:273525-276530:- | gene-YOL021C_Sparadoxus | rna-NM_001183275.1_Sparadoxus | cds-NP_014621.1_Sparadoxus | 91.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |