Gene name: DID4
Reference locus (S288C): YKL002W
Gene biotype: protein_coding
Description: DOA4-independent degradation protein 4; Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; Belongs to the SNF7 family
Top 10 interactors (score): DID2 (0.999); SNF7 (0.999); VPS28 (0.999); VPS24 (0.999); VPS4 (0.999); VPS20 (0.999); VPS36 (0.999); VPS60 (0.999); VPS25 (0.999); STP22 (0.998); SNF8 (0.998); IST1 (0.995); VPS27 (0.993); SRN2 (0.989); MVB12 (0.98); HSE1 (0.968); CHM7 (0.966); DOA4 (0.966); ATG8 (0.949); BRO1 (0.946)
Homologues (species, bitscore): CHMP2A (Homo sapiens, 198.4); Chmp2a (Mus musculus, 196.8); bc2 (Danio rerio, 204.1); chmp2a (Xenopus tropicalis, 204.1); Vps2 (Drosophila melanogaster, 193.7); vps-2 (Caenorhabditis elegans, 197.2); VPS2.1 (Arabidopsis thaliana, 197.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:423795-424561:+ | gene-YKL002W_AKU4011 | rna-NM_001179568.1_AKU4011 | cds-NP_012924.2_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:219359-220125:- | gene-YKL002W_BG1 | rna-NM_001179568.1_BG1 | cds-NP_012924.2_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:445485-446251:+ | gene-YKL002W_Bruggeman | rna-NM_001179568.1_Bruggeman | cds-NP_012924.2_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:440591-441357:+ | gene-YKL002W_CAT1 | rna-NM_001179568.1_CAT1 | cds-NP_012924.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:436513-437279:+ | gene-YKL002W_CBS1585 | rna-NM_001179568.1_CBS1585 | cds-NP_012924.2_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:435360-436126:+ | gene-YKL002W_CBS436 | rna-NM_001179568.1_CBS436 | cds-NP_012924.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:420671-421437:+ | gene-YKL002W_CBS6412 | rna-NM_001179568.1_CBS6412 | cds-NP_012924.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:436368-437134:+ | gene-YKL002W_CBS6413 | rna-NM_001179568.1_CBS6413 | cds-NP_012924.2_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:437455-438221:+ | gene-YKL002W_CENPK1137D | rna-NM_001179568.1_CENPK1137D | cds-NP_012924.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:434276-435042:+ | gene-YKL002W_EthanolRed | rna-NM_001179568.1_EthanolRed | cds-NP_012924.2_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:436366-437132:+ | gene-YKL002W_FaliES1 | rna-NM_001179568.1_FaliES1 | cds-NP_012924.2_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000120.1:19688-20454:- | gene-YKL002W_JAY291 | rna-NM_001179568.1_JAY291 | cds-NP_012924.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:444800-445566:+ | gene-YKL002W_MUCL30387 | rna-NM_001179568.1_MUCL30387 | cds-NP_012924.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:440410-441176:+ | gene-YKL002W_MUCL30388 | rna-NM_001179568.1_MUCL30388 | cds-NP_012924.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:435830-436596:+ | gene-YKL002W_MUCL39482 | rna-NM_001179568.1_MUCL39482 | cds-NP_012924.2_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:441644-442410:+ | gene-YKL002W_MUCL42920 | rna-NM_001179568.1_MUCL42920 | cds-NP_012924.2_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:437767-438533:+ | gene-YKL002W_NCIM3186 | rna-NM_001179568.1_NCIM3186 | cds-NP_012924.2_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:436038-436804:+ | gene-YKL002W_NCYC1407 | rna-NM_001179568.1_NCYC1407 | cds-NP_012924.2_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:460698-461464:+ | gene-YKL002W_PE2H3 | rna-NM_001179568.1_PE2H3 | cds-NP_012924.2_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:445440-446206:+ | gene-YKL002W_PE2H4 | rna-NM_001179568.1_PE2H4 | cds-NP_012924.2_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:437778-438544:+ | gene-YKL002W_S288C | rna-NM_001179568.1_S288C | cds-NP_012924.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:116042-116808:+ | gene-YKL002W_SA1 | rna-NM_001179568.1_SA1 | cds-NP_012924.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:436464-437230:+ | gene-YKL002W_ThermosaccDry | rna-NM_001179568.1_ThermosaccDry | cds-NP_012924.2_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:435721-436487:+ | gene-YKL002W_VR1 | rna-NM_001179568.1_VR1 | cds-NP_012924.2_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:434504-435270:+ | gene-YKL002W_ZTW1 | rna-NM_001179568.1_ZTW1 | cds-NP_012924.2_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:459490-460255:+ | gene-YKL002W_Sparadoxus | rna-NM_001179568.1_Sparadoxus | cds-NP_012924.2_Sparadoxus | 92.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |