Gene name: DHH1
Reference locus (S288C): YDL160C
Gene biotype: protein_coding
Description: Cytoplasmic DEAD-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacting with both decapping and deadenylase complexes; role in translational repression, mRNA decay, and possibly mRNA export; interacts and cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body (PB) assembly, while ATPase stimulation by Not1p promotes PB disassembly; forms cytoplasmic foci on replication stress; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily
Top 10 interactors (score): PAT1 (0.999); LSM1 (0.999); DCP2 (0.999); PBP1 (0.999); LSM4 (0.999); EDC3 (0.999); SCD6 (0.999); CDC39 (0.999); DCP1 (0.999); PAB1 (0.998); CDC33 (0.998); LSM2 (0.997); LSM7 (0.997); XRN1 (0.997); LSM3 (0.992); CCR4 (0.992); LSM12 (0.986); LSM6 (0.986); TIS11 (0.981); POP2 (0.981)
Homologues (species, bitscore): DDX6 (Homo sapiens, 592.8); Ddx6 (Mus musculus, 593.2); ddx61 (Danio rerio, 596.3); ddx6 (Xenopus tropicalis, 585.5); me31B (Drosophila melanogaster, 598.2); cgh-1 (Caenorhabditis elegans, 592.0); RH8 (Arabidopsis thaliana, 607.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:154831-156351:- | gene-YDL160C_AKU4011 | rna-NM_001180220.1_AKU4011 | cds-NP_010121.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:393433-394953:+ | gene-YDL160C_BG1 | rna-NM_001180220.1_BG1 | cds-NP_010121.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:170876-172396:- | gene-YDL160C_Bruggeman | rna-NM_001180220.1_Bruggeman | cds-NP_010121.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:169192-170712:- | gene-YDL160C_CAT1 | rna-NM_001180220.1_CAT1 | cds-NP_010121.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:152862-154382:- | gene-YDL160C_CBS1585 | rna-NM_001180220.1_CBS1585 | cds-NP_010121.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:169801-171321:- | gene-YDL160C_CBS436 | rna-NM_001180220.1_CBS436 | cds-NP_010121.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:152115-153635:- | gene-YDL160C_CBS6412 | rna-NM_001180220.1_CBS6412 | cds-NP_010121.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:171300-172820:- | gene-YDL160C_CBS6413 | rna-NM_001180220.1_CBS6413 | cds-NP_010121.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:169062-170582:- | gene-YDL160C_CENPK1137D | rna-NM_001180220.1_CENPK1137D | cds-NP_010121.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:166070-167590:- | gene-YDL160C_EthanolRed | rna-NM_001180220.1_EthanolRed | cds-NP_010121.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:171602-173122:- | gene-YDL160C_FaliES1 | rna-NM_001180220.1_FaliES1 | cds-NP_010121.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000032.1:46433-47953:+ | gene-YDL160C_JAY291 | rna-NM_001180220.1_JAY291 | cds-NP_010121.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:169190-170710:- | gene-YDL160C_MUCL30387 | rna-NM_001180220.1_MUCL30387 | cds-NP_010121.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:160848-162368:- | gene-YDL160C_MUCL30388 | rna-NM_001180220.1_MUCL30388 | cds-NP_010121.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:154017-155537:- | gene-YDL160C_MUCL39482 | rna-NM_001180220.1_MUCL39482 | cds-NP_010121.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | MBVV01000307.1:13853-15373:+ | gene-YDL160C_MUCL42920 | rna-NM_001180220.1_MUCL42920 | cds-NP_010121.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:170333-171853:- | gene-YDL160C_NCIM3186 | rna-NM_001180220.1_NCIM3186 | cds-NP_010121.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:153950-155470:- | gene-YDL160C_NCYC1407 | rna-NM_001180220.1_NCYC1407 | cds-NP_010121.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:161185-162705:- | gene-YDL160C_PE2H3 | rna-NM_001180220.1_PE2H3 | cds-NP_010121.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:161189-162709:- | gene-YDL160C_PE2H4 | rna-NM_001180220.1_PE2H4 | cds-NP_010121.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:170410-171930:- | gene-YDL160C_S288C | rna-NM_001180220.1_S288C | cds-NP_010121.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000043.1:35969-37489:- | gene-YDL160C_SA1 | rna-NM_001180220.1_SA1 | cds-NP_010121.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:171363-172883:- | gene-YDL160C_ThermosaccDry | rna-NM_001180220.1_ThermosaccDry | cds-NP_010121.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:171956-173476:- | gene-YDL160C_VR1 | rna-NM_001180220.1_VR1 | cds-NP_010121.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:169490-171010:- | gene-YDL160C_ZTW1 | rna-NM_001180220.1_ZTW1 | cds-NP_010121.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:171641-173161:- | gene-YDL160C_Sparadoxus | rna-NM_001180220.1_Sparadoxus | cds-NP_010121.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |