Gene name: DFR1
Reference locus (S288C): YOR236W
Gene biotype: protein_coding
Description: Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR
Top 10 interactors (score): CDC21 (0.999); MET7 (0.989); SHM1 (0.983); ADE8 (0.982); FOL3 (0.979); SHM2 (0.979); GCV2 (0.978); GCV1 (0.978); GCV3 (0.971); MIS1 (0.971); FOL2 (0.966); MCM4 (0.961); RMA1 (0.961); ADE17 (0.959); FMT1 (0.959); ADE3 (0.959); FOL1 (0.958); ADE16 (0.958); FSH3 (0.957); LPD1 (0.945)
Homologues (species, bitscore): DHFR (Homo sapiens, 79.3); Dhfr (Mus musculus, 84.0); dhfr (Danio rerio, 95.1); dhfr (Xenopus tropicalis, 91.3); Dhfr (Drosophila melanogaster, 97.1); dhfr-1 (Caenorhabditis elegans, 94.0); THY-2 (Arabidopsis thaliana, 109.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:771678-772313:+ | gene-YOR236W_AKU4011 | rna-NM_001183655.1_AKU4011 | cds-NP_014879.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:173718-174353:+ | gene-YOR236W_BG1 | rna-NM_001183655.1_BG1 | cds-NP_014879.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:757145-757780:+ | gene-YOR236W_Bruggeman | rna-NM_001183655.1_Bruggeman | cds-NP_014879.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:757795-758430:+ | gene-YOR236W_CAT1 | rna-NM_001183655.1_CAT1 | cds-NP_014879.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:754667-755302:+ | gene-YOR236W_CBS1585 | rna-NM_001183655.1_CBS1585 | cds-NP_014879.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:753362-753997:+ | gene-YOR236W_CBS436 | rna-NM_001183655.1_CBS436 | cds-NP_014879.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:751786-752421:+ | gene-YOR236W_CBS6412 | rna-NM_001183655.1_CBS6412 | cds-NP_014879.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:760426-761061:+ | gene-YOR236W_CBS6413 | rna-NM_001183655.1_CBS6413 | cds-NP_014879.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:780668-781303:+ | gene-YOR236W_CENPK1137D | rna-NM_001183655.1_CENPK1137D | cds-NP_014879.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:747798-748433:+ | gene-YOR236W_EthanolRed | rna-NM_001183655.1_EthanolRed | cds-NP_014879.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:753197-753832:+ | gene-YOR236W_FaliES1 | rna-NM_001183655.1_FaliES1 | cds-NP_014879.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:73005-73640:- | gene-YOR236W_JAY291 | rna-NM_001183655.1_JAY291 | cds-NP_014879.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:761416-762051:+ | gene-YOR236W_MUCL30387 | rna-NM_001183655.1_MUCL30387 | cds-NP_014879.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:768534-769169:+ | gene-YOR236W_MUCL30388 | rna-NM_001183655.1_MUCL30388 | cds-NP_014879.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:761997-762632:+ | gene-YOR236W_MUCL39482 | rna-NM_001183655.1_MUCL39482 | cds-NP_014879.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:771586-772221:+ | gene-YOR236W_MUCL42920 | rna-NM_001183655.1_MUCL42920 | cds-NP_014879.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:780795-781430:+ | gene-YOR236W_NCIM3186 | rna-NM_001183655.1_NCIM3186 | cds-NP_014879.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:762096-762731:+ | gene-YOR236W_NCYC1407 | rna-NM_001183655.1_NCYC1407 | cds-NP_014879.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:761398-762033:+ | gene-YOR236W_PE2H3 | rna-NM_001183655.1_PE2H3 | cds-NP_014879.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:771775-772410:+ | gene-YOR236W_PE2H4 | rna-NM_001183655.1_PE2H4 | cds-NP_014879.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:780906-781541:+ | gene-YOR236W_S288C | rna-NM_001183655.1_S288C | cds-NP_014879.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:190899-191534:+ | gene-YOR236W_SA1 | rna-NM_001183655.1_SA1 | cds-NP_014879.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:752380-753015:+ | gene-YOR236W_ThermosaccDry | rna-NM_001183655.1_ThermosaccDry | cds-NP_014879.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:815838-816473:+ | gene-YOR236W_VR1 | rna-NM_001183655.1_VR1 | cds-NP_014879.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:485299-485934:+ | gene-YOR236W_ZTW1 | rna-NM_001183655.1_ZTW1 | cds-NP_014879.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:758290-758925:+ | gene-YOR236W_Sparadoxus | rna-NM_001183655.1_Sparadoxus | cds-NP_014879.1_Sparadoxus | 88.7 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |