Gene name: DFM1
Reference locus (S288C): YDR411C
Gene biotype: protein_coding
Description: DER1-like family member protein 1; Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p; Belongs to the derlin family
Top 10 interactors (score): CDC48 (0.992); DER1 (0.983); YPF1 (0.946); HRD3 (0.929); HRD1 (0.929); UBX2 (0.923); YOS9 (0.923); UFD1 (0.9); SEC61 (0.896); KAR2 (0.872); NPL4 (0.872); SSM4 (0.86); USA1 (0.818); UBX7 (0.783); UBC7 (0.714); UBX4 (0.701); SEC62 (0.677); MNL1 (0.656); CUE1 (0.651); DSC2 (0.603)
Homologues (species, bitscore): DERL2 (Homo sapiens, 68.6); Derl2 (Mus musculus, 68.6); derl2 (Danio rerio, 69.3); derl2 (Xenopus tropicalis, 70.5); Der-2 (Drosophila melanogaster, 57.8); R151.6 (Caenorhabditis elegans, 69.3); DER1 (Arabidopsis thaliana, 71.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1233522-1234547:- | gene-YDR411C_AKU4011 | rna-NM_001180719.1_AKU4011 | cds-NP_010699.1_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:112005-113030:- | gene-YDR411C_BG1 | rna-NM_001180719.1_BG1 | cds-NP_010699.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1264403-1265428:- | gene-YDR411C_Bruggeman | rna-NM_001180719.1_Bruggeman | cds-NP_010699.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1242963-1243988:- | gene-YDR411C_CAT1 | rna-NM_001180719.1_CAT1 | cds-NP_010699.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1228442-1229467:- | gene-YDR411C_CBS1585 | rna-NM_001180719.1_CBS1585 | cds-NP_010699.1_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1247301-1248326:- | gene-YDR411C_CBS436 | rna-NM_001180719.1_CBS436 | cds-NP_010699.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1224496-1225521:- | gene-YDR411C_CBS6412 | rna-NM_001180719.1_CBS6412 | cds-NP_010699.1_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1246351-1247376:- | gene-YDR411C_CBS6413 | rna-NM_001180719.1_CBS6413 | cds-NP_010699.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1292028-1293053:- | gene-YDR411C_CENPK1137D | rna-NM_001180719.1_CENPK1137D | cds-NP_010699.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1237910-1238935:- | gene-YDR411C_EthanolRed | rna-NM_001180719.1_EthanolRed | cds-NP_010699.1_EthanolRed | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1241217-1242242:- | gene-YDR411C_FaliES1 | rna-NM_001180719.1_FaliES1 | cds-NP_010699.1_FaliES1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000445.1:2364-3389:+ | gene-YDR411C_1_JAY291 | Unknown | Unknown | 100.0 | 100.0 | Verified | 2 | 2 | 1 | Unknown | Unknown | Unknown | Unknown | Unknown |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000181.1:13271-14296:+ | gene-YDR411C_JAY291 | rna-NM_001180719.1_JAY291 | cds-NP_010699.1_JAY291 | 100.0 | 100.0 | Verified | 2 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1247965-1248990:- | gene-YDR411C_MUCL30387 | rna-NM_001180719.1_MUCL30387 | cds-NP_010699.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1230071-1231096:- | gene-YDR411C_MUCL30388 | rna-NM_001180719.1_MUCL30388 | cds-NP_010699.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1219770-1220795:- | gene-YDR411C_MUCL39482 | rna-NM_001180719.1_MUCL39482 | cds-NP_010699.1_MUCL39482 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1162201-1163226:- | gene-YDR411C_MUCL42920 | rna-NM_001180719.1_MUCL42920 | cds-NP_010699.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1293292-1294317:- | gene-YDR411C_NCIM3186 | rna-NM_001180719.1_NCIM3186 | cds-NP_010699.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1233742-1234767:- | gene-YDR411C_NCYC1407 | rna-NM_001180719.1_NCYC1407 | cds-NP_010699.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1243874-1244899:- | gene-YDR411C_PE2H3 | rna-NM_001180719.1_PE2H3 | cds-NP_010699.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1249442-1250467:- | gene-YDR411C_PE2H4 | rna-NM_001180719.1_PE2H4 | cds-NP_010699.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1293369-1294394:- | gene-YDR411C_S288C | rna-NM_001180719.1_S288C | cds-NP_010699.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000071.1:13393-14418:+ | gene-YDR411C_SA1 | rna-NM_001180719.1_SA1 | cds-NP_010699.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1245479-1246504:- | gene-YDR411C_ThermosaccDry | rna-NM_001180719.1_ThermosaccDry | cds-NP_010699.1_ThermosaccDry | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1260681-1261706:- | gene-YDR411C_VR1 | rna-NM_001180719.1_VR1 | cds-NP_010699.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:288291-289316:- | gene-YDR411C_ZTW1 | rna-NM_001180719.1_ZTW1 | cds-NP_010699.1_ZTW1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1240707-1241732:- | gene-YDR411C_Sparadoxus | rna-NM_001180719.1_Sparadoxus | cds-NP_010699.1_Sparadoxus | 88.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |