Gene name: DER1
Reference locus (S288C): YBR201W
Gene biotype: protein_coding
Description: Degradation in the endoplasmic reticulum protein 1; ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1
Top 10 interactors (score): CDC48 (0.999); USA1 (0.999); UBX2 (0.999); HRD3 (0.999); YOS9 (0.999); HRD1 (0.999); UFD1 (0.999); NPL4 (0.997); UBC7 (0.993); SSM4 (0.993); SEC61 (0.992); CUE1 (0.99); DFM1 (0.983); KAR2 (0.973); MNL1 (0.958); UBX3 (0.953); PRC1 (0.929); ERV41 (0.929); CNE1 (0.923); FKH1 (0.918)
Homologues (species, bitscore): DERL3 (Homo sapiens, 50.4); Derl3 (Mus musculus, 52.0); R151.6 (Caenorhabditis elegans, 60.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:606947-607582:+ | gene-YBR201W_AKU4011 | rna-NM_001178549.1_AKU4011 | cds-NP_009760.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:596947-597582:+ | gene-YBR201W_BG1 | rna-NM_001178549.1_BG1 | cds-NP_009760.1_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:412802-413437:+ | gene-YBR201W_Bruggeman | rna-NM_001178549.1_Bruggeman | cds-NP_009760.1_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:612208-612843:+ | gene-YBR201W_CAT1 | rna-NM_001178549.1_CAT1 | cds-NP_009760.1_CAT1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:598728-599363:+ | gene-YBR201W_CBS1585 | rna-NM_001178549.1_CBS1585 | cds-NP_009760.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:606273-606908:+ | gene-YBR201W_CBS436 | rna-NM_001178549.1_CBS436 | cds-NP_009760.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:695337-695972:+ | gene-YBR201W_CBS6412 | rna-NM_001178549.1_CBS6412 | cds-NP_009760.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:604534-605169:+ | gene-YBR201W_CBS6413 | rna-NM_001178549.1_CBS6413 | cds-NP_009760.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:617350-617985:+ | gene-YBR201W_CENPK1137D | rna-NM_001178549.1_CENPK1137D | cds-NP_009760.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:732106-732741:+ | gene-YBR201W_EthanolRed | rna-NM_001178549.1_EthanolRed | cds-NP_009760.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:623017-623652:+ | gene-YBR201W_FaliES1 | rna-NM_001178549.1_FaliES1 | cds-NP_009760.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000023.1:16614-17249:+ | gene-YBR201W_JAY291 | rna-NM_001178549.1_JAY291 | cds-NP_009760.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:611481-612116:+ | gene-YBR201W_MUCL30387 | rna-NM_001178549.1_MUCL30387 | cds-NP_009760.1_MUCL30387 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:628558-629193:+ | gene-YBR201W_MUCL30388 | rna-NM_001178549.1_MUCL30388 | cds-NP_009760.1_MUCL30388 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:597101-597736:+ | gene-YBR201W_MUCL39482 | rna-NM_001178549.1_MUCL39482 | cds-NP_009760.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:606527-607162:+ | gene-YBR201W_MUCL42920 | rna-NM_001178549.1_MUCL42920 | cds-NP_009760.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:623373-624008:+ | gene-YBR201W_NCIM3186 | rna-NM_001178549.1_NCIM3186 | cds-NP_009760.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:599209-599844:+ | gene-YBR201W_NCYC1407 | rna-NM_001178549.1_NCYC1407 | cds-NP_009760.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:611819-612454:+ | gene-YBR201W_PE2H3 | rna-NM_001178549.1_PE2H3 | cds-NP_009760.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:609495-610130:+ | gene-YBR201W_PE2H4 | rna-NM_001178549.1_PE2H4 | cds-NP_009760.1_PE2H4 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:623576-624211:+ | gene-YBR201W_S288C | rna-NM_001178549.1_S288C | cds-NP_009760.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000080.1:31269-31904:+ | gene-YBR201W_SA1 | rna-NM_001178549.1_SA1 | cds-NP_009760.1_SA1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:622027-622662:+ | gene-YBR201W_ThermosaccDry | rna-NM_001178549.1_ThermosaccDry | cds-NP_009760.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:603195-603830:+ | gene-YBR201W_VR1 | rna-NM_001178549.1_VR1 | cds-NP_009760.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:596644-597279:+ | gene-YBR201W_ZTW1 | rna-NM_001178549.1_ZTW1 | cds-NP_009760.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:639284-639919:+ | gene-YBR201W_Sparadoxus | rna-NM_001178549.1_Sparadoxus | cds-NP_009760.1_Sparadoxus | 89.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |