Gene name: DEF1
Reference locus (S288C): YKL054C
Gene biotype: protein_coding
Description: RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
Top 10 interactors (score): RAD26 (0.99); RPO21 (0.867); RRM3 (0.799); RAD7 (0.789); RAD14 (0.767); ELC1 (0.747); REV7 (0.663); GPI19 (0.66); ECO1 (0.645); UBP3 (0.642); SSL1 (0.607); MPT5 (0.602); DCP2 (0.599); ELA1 (0.599); MOT2 (0.598); REV1 (0.597); POL3 (0.588); KRE29 (0.573); PIF1 (0.573); POL31 (0.572)
Homologues (species, bitscore): Zfhx3 (Mus musculus, 50.4); RBP47A (Arabidopsis thaliana, 53.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:322509-324740:- | gene-YKL054C_AKU4011 | rna-NM_001179620.1_AKU4011 | cds-NP_012869.1_AKU4011 | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:319259-321475:+ | gene-YKL054C_BG1 | rna-NM_001179620.1_BG1 | cds-NP_012869.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:341546-343771:- | gene-YKL054C_Bruggeman | rna-NM_001179620.1_Bruggeman | cds-NP_012869.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:337987-340199:- | gene-YKL054C_CAT1 | rna-NM_001179620.1_CAT1 | cds-NP_012869.1_CAT1 | 81.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:335239-337470:- | gene-YKL054C_CBS1585 | rna-NM_001179620.1_CBS1585 | cds-NP_012869.1_CBS1585 | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:333395-335611:- | gene-YKL054C_CBS436 | rna-NM_001179620.1_CBS436 | cds-NP_012869.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:319379-321604:- | gene-YKL054C_CBS6412 | rna-NM_001179620.1_CBS6412 | cds-NP_012869.1_CBS6412 | 97.6 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:335204-337432:- | gene-YKL054C_CBS6413 | rna-NM_001179620.1_CBS6413 | cds-NP_012869.1_CBS6413 | 97.7 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:336197-338413:- | gene-YKL054C_CENPK1137D | rna-NM_001179620.1_CENPK1137D | cds-NP_012869.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:333209-335425:- | gene-YKL054C_EthanolRed | rna-NM_001179620.1_EthanolRed | cds-NP_012869.1_EthanolRed | 97.5 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:334022-336238:- | gene-YKL054C_FaliES1 | rna-NM_001179620.1_FaliES1 | cds-NP_012869.1_FaliES1 | 97.5 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000080.1:38956-41172:- | gene-YKL054C_JAY291 | rna-NM_001179620.1_JAY291 | cds-NP_012869.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:342456-344681:- | gene-YKL054C_MUCL30387 | rna-NM_001179620.1_MUCL30387 | cds-NP_012869.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:337355-339570:- | gene-YKL054C_MUCL30388 | rna-NM_001179620.1_MUCL30388 | cds-NP_012869.1_MUCL30388 | 82.0 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:334535-336766:- | gene-YKL054C_MUCL39482 | rna-NM_001179620.1_MUCL39482 | cds-NP_012869.1_MUCL39482 | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:339444-341621:- | gene-YKL054C_MUCL42920 | rna-NM_001179620.1_MUCL42920 | cds-NP_012869.1_MUCL42920 | 96.2 | 97.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:336526-338742:- | gene-YKL054C_NCIM3186 | rna-NM_001179620.1_NCIM3186 | cds-NP_012869.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:334731-336962:- | gene-YKL054C_NCYC1407 | rna-NM_001179620.1_NCYC1407 | cds-NP_012869.1_NCYC1407 | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:359298-361514:- | gene-YKL054C_PE2H3 | rna-NM_001179620.1_PE2H3 | cds-NP_012869.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:344038-346254:- | gene-YKL054C_PE2H4 | rna-NM_001179620.1_PE2H4 | cds-NP_012869.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:336537-338753:- | gene-YKL054C_S288C | rna-NM_001179620.1_S288C | cds-NP_012869.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:14621-16846:- | gene-YKL054C_SA1 | rna-NM_001179620.1_SA1 | cds-NP_012869.1_SA1 | 97.4 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:335212-337428:- | gene-YKL054C_ThermosaccDry | rna-NM_001179620.1_ThermosaccDry | cds-NP_012869.1_ThermosaccDry | 97.5 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:334362-336574:- | gene-YKL054C_VR1 | rna-NM_001179620.1_VR1 | cds-NP_012869.1_VR1 | 81.7 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:333258-335456:- | gene-YKL054C_ZTW1 | rna-NM_001179620.1_ZTW1 | cds-NP_012869.1_ZTW1 | 98.3 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:352442-354658:- | gene-YKL054C_Sparadoxus | rna-NM_001179620.1_Sparadoxus | cds-NP_012869.1_Sparadoxus | 89.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |