Gene name: DDL1
Reference locus (S288C): YOR022C
Gene biotype: protein_coding
Description: DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism
Top 10 interactors (score): SEC31 (0.948); SEC23 (0.891); CLD1 (0.855); TRS130 (0.839); TRS120 (0.831); SEC13 (0.816); NTE1 (0.791); COQ8 (0.761); TAZ1 (0.748); MON2 (0.736); COQ9 (0.716); PLB3 (0.712); SPO1 (0.697); PLB2 (0.695); COQ5 (0.683); GYP1 (0.679); USO1 (0.675); RET3 (0.671); NEL1 (0.669); TAM41 (0.667)
Homologues (species, bitscore): DDHD2 (Homo sapiens, 104.8); Ddhd2 (Mus musculus, 106.3); ddhd1b (Danio rerio, 109.0); ddhd2 (Xenopus tropicalis, 94.0); CG8552 (Drosophila melanogaster, 113.2); ipla-1 (Caenorhabditis elegans, 110.9); SGR2 (Arabidopsis thaliana, 88.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:357920-360067:- | gene-YOR022C_AKU4011 | rna-NM_001183441.1_AKU4011 | cds-NP_014665.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:173503-175650:- | gene-YOR022C_BG1 | rna-NM_001183441.1_BG1 | cds-NP_014665.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:360665-362812:- | gene-YOR022C_Bruggeman | rna-NM_001183441.1_Bruggeman | cds-NP_014665.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:358821-360968:- | gene-YOR022C_CAT1 | rna-NM_001183441.1_CAT1 | cds-NP_014665.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:352613-354760:- | gene-YOR022C_CBS1585 | rna-NM_001183441.1_CBS1585 | cds-NP_014665.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:356972-359119:- | gene-YOR022C_CBS436 | rna-NM_001183441.1_CBS436 | cds-NP_014665.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:351966-354113:- | gene-YOR022C_CBS6412 | rna-NM_001183441.1_CBS6412 | cds-NP_014665.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:359342-361489:- | gene-YOR022C_CBS6413 | rna-NM_001183441.1_CBS6413 | cds-NP_014665.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:373593-375740:- | gene-YOR022C_CENPK1137D | rna-NM_001183441.1_CENPK1137D | cds-NP_014665.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:354623-356770:- | gene-YOR022C_EthanolRed | rna-NM_001183441.1_EthanolRed | cds-NP_014665.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:357971-360118:- | gene-YOR022C_FaliES1 | rna-NM_001183441.1_FaliES1 | cds-NP_014665.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000035.1:28619-30766:- | gene-YOR022C_JAY291 | rna-NM_001183441.1_JAY291 | cds-NP_014665.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:365054-367201:- | gene-YOR022C_MUCL30387 | rna-NM_001183441.1_MUCL30387 | cds-NP_014665.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:368487-370634:- | gene-YOR022C_MUCL30388 | rna-NM_001183441.1_MUCL30388 | cds-NP_014665.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:360096-362243:- | gene-YOR022C_MUCL39482 | rna-NM_001183441.1_MUCL39482 | cds-NP_014665.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:374911-377058:- | gene-YOR022C_MUCL42920 | rna-NM_001183441.1_MUCL42920 | cds-NP_014665.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:373599-375746:- | gene-YOR022C_NCIM3186 | rna-NM_001183441.1_NCIM3186 | cds-NP_014665.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:366798-368945:- | gene-YOR022C_NCYC1407 | rna-NM_001183441.1_NCYC1407 | cds-NP_014665.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:365639-367786:- | gene-YOR022C_PE2H3 | rna-NM_001183441.1_PE2H3 | cds-NP_014665.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:376018-378165:- | gene-YOR022C_PE2H4 | rna-NM_001183441.1_PE2H4 | cds-NP_014665.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:373710-375857:- | gene-YOR022C_S288C | rna-NM_001183441.1_S288C | cds-NP_014665.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:341505-343652:- | gene-YOR022C_SA1 | rna-NM_001183441.1_SA1 | cds-NP_014665.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:356511-358658:- | gene-YOR022C_ThermosaccDry | rna-NM_001183441.1_ThermosaccDry | cds-NP_014665.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:357400-359547:- | gene-YOR022C_VR1 | rna-NM_001183441.1_VR1 | cds-NP_014665.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:91140-93287:- | gene-YOR022C_ZTW1 | rna-NM_001183441.1_ZTW1 | cds-NP_014665.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:363681-365828:- | gene-YOR022C_Sparadoxus | rna-NM_001183441.1_Sparadoxus | cds-NP_014665.1_Sparadoxus | 88.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |