Gene name: DCK1
Reference locus (S288C): YLR422W
Gene biotype: protein_coding
Description: DOCK-like protein YLR422W; Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors
Top 10 interactors (score): CDC42 (0.995); LMO1 (0.953); CUE5 (0.92); RHO5 (0.917); POT1 (0.904); CAR1 (0.901); YFR018C (0.9); BUD16 (0.9); NIT3 (0.9); KAP95 (0.9); VID28 (0.9); PEP4 (0.9); RHO1 (0.807); ARF3 (0.772); RHO4 (0.762); RSR1 (0.714); RAS1 (0.688); RHO2 (0.672); RHO3 (0.652); FIP1 (0.646)
Homologues (species, bitscore): DOCK3 (Homo sapiens, 151.8); Dock3 (Mus musculus, 152.1); dock3 (Danio rerio, 150.2); dock4 (Xenopus tropicalis, 139.0); spg (Drosophila melanogaster, 149.8); ced-5 (Caenorhabditis elegans, 114.8); SPK1 (Arabidopsis thaliana, 73.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:909446-915244:+ | gene-YLR422W_AKU4011 | rna-NM_001182310.1_AKU4011 | cds-NP_013526.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:141611-147409:+ | gene-YLR422W_BG1 | rna-NM_001182310.1_BG1 | cds-NP_013526.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:947749-953547:+ | gene-YLR422W_Bruggeman | rna-NM_001182310.1_Bruggeman | cds-NP_013526.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:943296-949094:+ | gene-YLR422W_CAT1 | rna-NM_001182310.1_CAT1 | cds-NP_013526.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:945043-950841:+ | gene-YLR422W_CBS1585 | rna-NM_001182310.1_CBS1585 | cds-NP_013526.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:928700-934498:+ | gene-YLR422W_CBS436 | rna-NM_001182310.1_CBS436 | cds-NP_013526.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:981083-986881:+ | gene-YLR422W_CBS6412 | rna-NM_001182310.1_CBS6412 | cds-NP_013526.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:945335-951133:+ | gene-YLR422W_CBS6413 | rna-NM_001182310.1_CBS6413 | cds-NP_013526.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:945097-950895:+ | gene-YLR422W_CENPK1137D | rna-NM_001182310.1_CENPK1137D | cds-NP_013526.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:902326-908124:+ | gene-YLR422W_EthanolRed | rna-NM_001182310.1_EthanolRed | cds-NP_013526.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:931807-937605:+ | gene-YLR422W_FaliES1 | rna-NM_001182310.1_FaliES1 | cds-NP_013526.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:84440-90238:+ | gene-YLR422W_JAY291 | rna-NM_001182310.1_JAY291 | cds-NP_013526.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:946612-952410:+ | gene-YLR422W_MUCL30387 | rna-NM_001182310.1_MUCL30387 | cds-NP_013526.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:952715-958513:+ | gene-YLR422W_MUCL30388 | rna-NM_001182310.1_MUCL30388 | cds-NP_013526.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:946263-952061:+ | gene-YLR422W_MUCL39482 | rna-NM_001182310.1_MUCL39482 | cds-NP_013526.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:940920-946718:+ | gene-YLR422W_MUCL42920 | rna-NM_001182310.1_MUCL42920 | cds-NP_013526.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:965871-971669:+ | gene-YLR422W_NCIM3186 | rna-NM_001182310.1_NCIM3186 | cds-NP_013526.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:955442-961240:+ | gene-YLR422W_NCYC1407 | rna-NM_001182310.1_NCYC1407 | cds-NP_013526.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:941821-947619:+ | gene-YLR422W_PE2H3 | rna-NM_001182310.1_PE2H3 | cds-NP_013526.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:941565-947363:+ | gene-YLR422W_PE2H4 | rna-NM_001182310.1_PE2H4 | cds-NP_013526.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:965897-971695:+ | gene-YLR422W_S288C | rna-NM_001182310.1_S288C | cds-NP_013526.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:82978-88776:- | gene-YLR422W_SA1 | rna-NM_001182310.1_SA1 | cds-NP_013526.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:934886-940684:+ | gene-YLR422W_ThermosaccDry | rna-NM_001182310.1_ThermosaccDry | cds-NP_013526.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:947263-953061:+ | gene-YLR422W_VR1 | rna-NM_001182310.1_VR1 | cds-NP_013526.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:271099-276897:+ | gene-YLR422W_ZTW1 | rna-NM_001182310.1_ZTW1 | cds-NP_013526.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:920300-926098:+ | gene-YLR422W_Sparadoxus | rna-NM_001182310.1_Sparadoxus | cds-NP_013526.1_Sparadoxus | 90.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |