Gene name: DBR1
Reference locus (S288C): YKL149C
Gene biotype: protein_coding
Description: RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant
Top 10 interactors (score): PRP16 (0.996); DRN1 (0.975); UTP18 (0.96); RNT1 (0.896); PRP18 (0.856); MSN5 (0.811); PRP43 (0.752); PRP22 (0.746); SPT5 (0.734); DFG10 (0.712); XRN1 (0.711); CDC36 (0.701); PRP6 (0.672); VID28 (0.65); VPS29 (0.65); CRM1 (0.644); RAT1 (0.643); SYF1 (0.635); PAT1 (0.622); YIL071W-A (0.614)
Homologues (species, bitscore): DBR1 (Homo sapiens, 262.3); Dbr1 (Mus musculus, 263.5); dbr1 (Danio rerio, 260.8); dbr1 (Xenopus tropicalis, 250.4); ldbr (Drosophila melanogaster, 259.6); dbr-1 (Caenorhabditis elegans, 221.1); DBR1 (Arabidopsis thaliana, 235.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:154486-155703:- | gene-YKL149C_AKU4011 | rna-NM_001179715.1_AKU4011 | cds-NP_012773.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:131624-132841:- | gene-YKL149C_BG1 | rna-NM_001179715.1_BG1 | cds-NP_012773.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:172148-173365:- | gene-YKL149C_Bruggeman | rna-NM_001179715.1_Bruggeman | cds-NP_012773.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:167477-168694:- | gene-YKL149C_CAT1 | rna-NM_001179715.1_CAT1 | cds-NP_012773.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:166712-167929:- | gene-YKL149C_CBS1585 | rna-NM_001179715.1_CBS1585 | cds-NP_012773.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:165320-166537:- | gene-YKL149C_CBS436 | rna-NM_001179715.1_CBS436 | cds-NP_012773.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:151731-152948:- | gene-YKL149C_CBS6412 | rna-NM_001179715.1_CBS6412 | cds-NP_012773.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:167181-168398:- | gene-YKL149C_CBS6413 | rna-NM_001179715.1_CBS6413 | cds-NP_012773.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:167256-168473:- | gene-YKL149C_CENPK1137D | rna-NM_001179715.1_CENPK1137D | cds-NP_012773.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:165228-166445:- | gene-YKL149C_EthanolRed | rna-NM_001179715.1_EthanolRed | cds-NP_012773.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:166040-167257:- | gene-YKL149C_FaliES1 | rna-NM_001179715.1_FaliES1 | cds-NP_012773.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000198.1:2751-3968:- | gene-YKL149C_JAY291 | rna-NM_001179715.1_JAY291 | cds-NP_012773.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:174245-175462:- | gene-YKL149C_MUCL30387 | rna-NM_001179715.1_MUCL30387 | cds-NP_012773.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:168597-169814:- | gene-YKL149C_MUCL30388 | rna-NM_001179715.1_MUCL30388 | cds-NP_012773.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:166517-167734:- | gene-YKL149C_MUCL39482 | rna-NM_001179715.1_MUCL39482 | cds-NP_012773.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:170922-172139:- | gene-YKL149C_MUCL42920 | rna-NM_001179715.1_MUCL42920 | cds-NP_012773.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:167601-168818:- | gene-YKL149C_NCIM3186 | rna-NM_001179715.1_NCIM3186 | cds-NP_012773.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:166708-167925:- | gene-YKL149C_NCYC1407 | rna-NM_001179715.1_NCYC1407 | cds-NP_012773.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:173808-175025:- | gene-YKL149C_PE2H3 | rna-NM_001179715.1_PE2H3 | cds-NP_012773.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:170102-171319:- | gene-YKL149C_PE2H4 | rna-NM_001179715.1_PE2H4 | cds-NP_012773.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:167612-168829:- | gene-YKL149C_S288C | rna-NM_001179715.1_S288C | cds-NP_012773.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:84033-85250:- | gene-YKL149C_SA1 | rna-NM_001179715.1_SA1 | cds-NP_012773.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:166740-167957:- | gene-YKL149C_ThermosaccDry | rna-NM_001179715.1_ThermosaccDry | cds-NP_012773.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:166084-167301:- | gene-YKL149C_VR1 | rna-NM_001179715.1_VR1 | cds-NP_012773.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:165266-166483:- | gene-YKL149C_ZTW1 | rna-NM_001179715.1_ZTW1 | cds-NP_012773.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:181962-183179:- | gene-YKL149C_Sparadoxus | rna-NM_001179715.1_Sparadoxus | cds-NP_012773.1_Sparadoxus | 87.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |