Gene name: DBF4
Reference locus (S288C): YDR052C
Gene biotype: protein_coding
Description: Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation
Top 10 interactors (score): MCM2 (0.999); RAD53 (0.999); CDC45 (0.999); MCM4 (0.999); CDC7 (0.999); MCM10 (0.998); MCM5 (0.998); CDC6 (0.996); MCM6 (0.996); CDC5 (0.995); MCM7 (0.993); ORC2 (0.992); DPB11 (0.991); POL2 (0.986); MCM3 (0.985); CDC28 (0.975); SLD3 (0.974); DPB2 (0.969); ORC4 (0.963); ORC5 (0.958)
Homologues (species, bitscore): Dbf4 (Mus musculus, 50.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:536043-538166:- | gene-YDR052C_AKU4011 | rna-NM_001180360.3_AKU4011 | cds-NP_010337.3_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:17052-19166:+ | gene-YDR052C_BG1 | rna-NM_001180360.3_BG1 | cds-NP_010337.3_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:568389-570503:- | gene-YDR052C_Bruggeman | rna-NM_001180360.3_Bruggeman | cds-NP_010337.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:551393-553507:- | gene-YDR052C_CAT1 | rna-NM_001180360.3_CAT1 | cds-NP_010337.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:526999-529122:- | gene-YDR052C_CBS1585 | rna-NM_001180360.3_CBS1585 | cds-NP_010337.3_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:552167-554281:- | gene-YDR052C_CBS436 | rna-NM_001180360.3_CBS436 | cds-NP_010337.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:523411-525534:- | gene-YDR052C_CBS6412 | rna-NM_001180360.3_CBS6412 | cds-NP_010337.3_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:552080-554203:- | gene-YDR052C_CBS6413 | rna-NM_001180360.3_CBS6413 | cds-NP_010337.3_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:557486-559600:- | gene-YDR052C_CENPK1137D | rna-NM_001180360.3_CENPK1137D | cds-NP_010337.3_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:537871-539994:- | gene-YDR052C_EthanolRed | rna-NM_001180360.3_EthanolRed | cds-NP_010337.3_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:544311-546434:- | gene-YDR052C_FaliES1 | rna-NM_001180360.3_FaliES1 | cds-NP_010337.3_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:8286-10400:+ | gene-YDR052C_JAY291 | rna-NM_001180360.3_JAY291 | cds-NP_010337.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:553056-555170:- | gene-YDR052C_MUCL30387 | rna-NM_001180360.3_MUCL30387 | cds-NP_010337.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:543470-545584:- | gene-YDR052C_MUCL30388 | rna-NM_001180360.3_MUCL30388 | cds-NP_010337.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:528370-530493:- | gene-YDR052C_MUCL39482 | rna-NM_001180360.3_MUCL39482 | cds-NP_010337.3_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:458598-460712:- | gene-YDR052C_MUCL42920 | rna-NM_001180360.3_MUCL42920 | cds-NP_010337.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:558434-560548:- | gene-YDR052C_NCIM3186 | rna-NM_001180360.3_NCIM3186 | cds-NP_010337.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:527305-529428:- | gene-YDR052C_NCYC1407 | rna-NM_001180360.3_NCYC1407 | cds-NP_010337.3_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:546936-549050:- | gene-YDR052C_PE2H3 | rna-NM_001180360.3_PE2H3 | cds-NP_010337.3_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:546241-548355:- | gene-YDR052C_PE2H4 | rna-NM_001180360.3_PE2H4 | cds-NP_010337.3_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:558511-560625:- | gene-YDR052C_S288C | rna-NM_001180360.3_S288C | cds-NP_010337.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:84865-86979:+ | gene-YDR052C_SA1 | rna-NM_001180360.3_SA1 | cds-NP_010337.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:544051-546174:- | gene-YDR052C_ThermosaccDry | rna-NM_001180360.3_ThermosaccDry | cds-NP_010337.3_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:556749-558863:- | gene-YDR052C_VR1 | rna-NM_001180360.3_VR1 | cds-NP_010337.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:541655-543778:- | gene-YDR052C_ZTW1 | rna-NM_001180360.3_ZTW1 | cds-NP_010337.3_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:546065-548167:- | gene-YDR052C_Sparadoxus | rna-NM_001180360.3_Sparadoxus | cds-NP_010337.3_Sparadoxus | 89.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |