Gene name: CYS4
Reference locus (S288C): YGR155W
Gene biotype: protein_coding
Description: Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant
Top 10 interactors (score): CYS3 (0.999); STR3 (0.994); MET17 (0.992); STR2 (0.992); YLL058W (0.989); SAH1 (0.988); MET6 (0.979); TRP5 (0.968); ILV1 (0.966); YML082W (0.966); SAM4 (0.959); MHT1 (0.953); IRC7 (0.951); SER2 (0.948); SHM2 (0.946); SHM1 (0.944); GSH1 (0.944); MET2 (0.94); CHA1 (0.931); AGX1 (0.917)
Homologues (species, bitscore): CBSL (Homo sapiens, 386.3); Cbs (Mus musculus, 395.2); cbsb (Danio rerio, 398.7); cbs (Xenopus tropicalis, 82.8); Cbs (Drosophila melanogaster, 372.9); cbs-2 (Caenorhabditis elegans, 338.2); OASC (Arabidopsis thaliana, 212.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:778156-779679:+ | gene-YGR155W_AKU4011 | rna-NM_001181284.3_AKU4011 | cds-NP_011671.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:56306-57829:+ | gene-YGR155W_BG1 | rna-NM_001181284.3_BG1 | cds-NP_011671.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:783861-785384:+ | gene-YGR155W_Bruggeman | rna-NM_001181284.3_Bruggeman | cds-NP_011671.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:779920-781443:+ | gene-YGR155W_CAT1 | rna-NM_001181284.3_CAT1 | cds-NP_011671.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:778890-780413:+ | gene-YGR155W_CBS1585 | rna-NM_001181284.3_CBS1585 | cds-NP_011671.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:782774-784297:+ | gene-YGR155W_CBS436 | rna-NM_001181284.3_CBS436 | cds-NP_011671.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:769910-771433:+ | gene-YGR155W_CBS6412 | rna-NM_001181284.3_CBS6412 | cds-NP_011671.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:775748-777271:+ | gene-YGR155W_CBS6413 | rna-NM_001181284.3_CBS6413 | cds-NP_011671.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:798276-799799:+ | gene-YGR155W_CENPK1137D | rna-NM_001181284.3_CENPK1137D | cds-NP_011671.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:764459-765982:+ | gene-YGR155W_EthanolRed | rna-NM_001181284.3_EthanolRed | cds-NP_011671.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:768663-770186:+ | gene-YGR155W_FaliES1 | rna-NM_001181284.3_FaliES1 | cds-NP_011671.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000112.1:11064-12587:+ | gene-YGR155W_JAY291 | rna-NM_001181284.3_JAY291 | cds-NP_011671.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:781600-783123:+ | gene-YGR155W_MUCL30387 | rna-NM_001181284.3_MUCL30387 | cds-NP_011671.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:781289-782812:+ | gene-YGR155W_MUCL30388 | rna-NM_001181284.3_MUCL30388 | cds-NP_011671.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:774457-775980:+ | gene-YGR155W_MUCL39482 | rna-NM_001181284.3_MUCL39482 | cds-NP_011671.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:789401-790924:+ | gene-YGR155W_MUCL42920 | rna-NM_001181284.3_MUCL42920 | cds-NP_011671.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:798543-800066:+ | gene-YGR155W_NCIM3186 | rna-NM_001181284.3_NCIM3186 | cds-NP_011671.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:769566-771089:+ | gene-YGR155W_NCYC1407 | rna-NM_001181284.3_NCYC1407 | cds-NP_011671.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:788767-790290:+ | gene-YGR155W_PE2H3 | rna-NM_001181284.3_PE2H3 | cds-NP_011671.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:793877-795400:+ | gene-YGR155W_PE2H4 | rna-NM_001181284.3_PE2H4 | cds-NP_011671.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:798543-800066:+ | gene-YGR155W_S288C | rna-NM_001181284.3_S288C | cds-NP_011671.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:33692-35215:+ | gene-YGR155W_SA1 | rna-NM_001181284.3_SA1 | cds-NP_011671.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:789170-790693:+ | gene-YGR155W_ThermosaccDry | rna-NM_001181284.3_ThermosaccDry | cds-NP_011671.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:893674-895197:+ | gene-YGR155W_VR1 | rna-NM_001181284.3_VR1 | cds-NP_011671.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:91111-92634:+ | gene-YGR155W_ZTW1 | rna-NM_001181284.3_ZTW1 | cds-NP_011671.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:778742-780265:+ | gene-YGR155W_Sparadoxus | rna-NM_001181284.3_Sparadoxus | cds-NP_011671.3_Sparadoxus | 90.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |